Optical bundle apparatus and method for optical and/or electrical nerve stimulation of peripheral nerves
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-005/06
A61N-001/05
A61N-001/36
출원번호
US-0117118
(2011-05-26)
등록번호
US-8864806
(2014-10-21)
발명자
/ 주소
Wells, Jonathon D.
Xing, Andrew
Bendett, Mark P.
Keller, Matthew D.
Lemaire, Charles A.
출원인 / 주소
Lockheed Martin Corporation
대리인 / 주소
Lemaire, Charles A.
인용정보
피인용 횟수 :
0인용 특허 :
182
초록▼
Apparatus and method for making and using devices that generate optical signals, and optionally also electrical signals in combination with one or more such optical signals, to stimulate (i.e., trigger) and/or simulate a sensory-nerve signal in nerve and/or brain tissue of a living animal (e.g., a h
Apparatus and method for making and using devices that generate optical signals, and optionally also electrical signals in combination with one or more such optical signals, to stimulate (i.e., trigger) and/or simulate a sensory-nerve signal in nerve and/or brain tissue of a living animal (e.g., a human), for example to treat nerve damage in the peripheral nervous system (PNS) or the central nervous system (CNS) and provide sensations to stimulate and/or simulate “sensory” signals in nerves and/or brain tissue of a living animal (e.g., a human) to treat other sensory deficiencies (e.g., touch, feel, balance, visual, taste, or olfactory) and provide sensations related to those sensory deficiencies, and/or to stimulate (i.e., trigger) and/or simulate a motor-nerve signal in nerve and/or brain tissue of a living animal (e.g., a human), for example to control a muscle or a robotic prosthesis.
대표청구항▼
1. An apparatus comprising: a non-transitory computer-readable memory having a stored mapping of stimulation signals to responses stored therein;a plurality of laser light sources operatively coupled to the computer-readable memory and configured to generate a plurality of independently controlled l
1. An apparatus comprising: a non-transitory computer-readable memory having a stored mapping of stimulation signals to responses stored therein;a plurality of laser light sources operatively coupled to the computer-readable memory and configured to generate a plurality of independently controlled laser light signals from selected ones of the plurality of laser light sources based on the stored mapping;a plurality of concentric waveguide bundles including a first waveguide bundle, and a second waveguide bundle arranged to encircle the first waveguide bundle, wherein the plurality of waveguide bundles is operatively coupled to the plurality of laser light sources,wherein the plurality of waveguide bundles is configured to emit the plurality of independently controlled laser light signals toward a first plurality of peripheral nerves in a nerve bundle of an animal in order to independently and separately optically stimulate selected ones of the first plurality of peripheral nerves of the animal,wherein the first waveguide bundle includes a first plurality of waveguides that have a first length and are arranged around a longitudinal axis,wherein the second waveguide bundle includes a second plurality of waveguides that have a second length and are arranged around the longitudinal axis, andwherein the first length is not equal to the second length;a controller operatively coupled to the plurality of laser light sources and configured to selectively control selected ones of the plurality of laser light signals emitted from selected ones of the first and second plurality of waveguides, wherein the selective control of the plurality of laser light signals provides controlled optical stimulation to the selected ones of the first plurality of peripheral nerves of the animal that independently triggers action potentials in the selected ones of the first plurality of peripheral nerves; anda plurality of insulated electrical conductors extending along the first waveguide bundle and operatively coupled to the controller, the plurality of electrical conductors including a first electrical conductor connected to a first exposed electrode and a second electrical conductor connected to a second exposed electrode, wherein the controller is configured to selectively apply an electrical signal to the first electrical conductor and the second electrical conductor to create an electric field across a volume of tissue of the animal between the first electrode and the second electrode. 2. The apparatus of claim 1, wherein the plurality of laser light sources includes a plurality of vertical-cavity-surface-emitting lasers (VCSELs). 3. The apparatus of claim 1, wherein each of the first plurality of waveguides includes a faceted end configured to transmit its corresponding laser light signal in a direction that is not parallel to the longitudinal axis but is at least partially radially outward from the longitudinal axis. 4. The apparatus of claim 3, wherein the first waveguide bundle is configured such that a face of the faceted end of each of the first plurality of waveguides points in a different direction that is radially-outward and longitudinally angled with respect to the longitudinal axis. 5. The apparatus of claim 2, wherein the first plurality of waveguides and the first waveguide bundle are configured to reflect light out of each of the first plurality of waveguides in a direction that is at least partially radially outward from the longitudinal axis. 6. The apparatus of claim 1, wherein the apparatus is a first optical stimulation device of a plurality of optical stimulation devices including the first optical stimulation device and a second optical stimulation device, wherein laser light signals emitted from the first optical stimulation device onto the first plurality of peripheral nerves is insufficient alone to stimulate a nerve action potential (NAP) in the first plurality of peripheral nerves, and wherein laser light signals from the second optical stimulation device onto the first plurality of peripheral nerves of the patient is insufficient alone to stimulate a NAP in the first plurality of peripheral nerves, but wherein laser light signals from the first optical stimulation device and laser light signals from the second optical stimulation device intersecting onto the first plurality of peripheral nerves deliver a trigger amount of pulsed light sufficient to stimulate a NAP in the first plurality of peripheral nerves. 7. An apparatus comprising: a plurality of laser light sources configured to generate a plurality of independently controlled laser light signals;a plurality of concentric waveguide bundles including a first waveguide bundle, and a second waveguide bundle arranged around the first waveguide bundle, wherein the plurality of waveguide bundles is operatively coupled to the plurality of laser light sources,wherein the plurality of waveguide bundles is configured to emit the plurality of independently controlled laser light signals toward a first plurality of peripheral nerves in a nerve bundle of an animal in order to independently and separately optically stimulate the first plurality of peripheral nerves of the animal,wherein the first waveguide bundle includes a first plurality of waveguides that have a first length and are arranged around a longitudinal axis, andwherein the second waveguide bundle includes a second plurality of waveguides that have a second length and are arranged around the longitudinal axis;a controller operatively coupled to the plurality of laser light sources and configured to selectively control the plurality of laser light signals emitted from each of the plurality of waveguide bundles such that the plurality of laser light signals provide controlled optical stimulation to the first plurality of peripheral nerves of the animal that triggers action potentials in the first plurality of peripheral nerves; anda first plurality of insulated electrical conductors extending along the first waveguide bundle and operatively coupled to the controller, the plurality of electrical conductors including a first electrical conductor connected to a first exposed electrode and a second electrical conductor connected to a second exposed electrode, and wherein the controller is configured to selectively apply an electrical signal to the first electrical conductor and the second electrical conductor to create an electric field across a volume of tissue of the animal between the first electrode and the second electrode. 8. The apparatus of claim 7, wherein the first plurality of insulated electrical conductors further includes a third electrical conductor connected to the controller and to a third exposed electrode, and wherein the controller is configured to selectively and independently control an electrical field through tissue of the animal between the first electrode and the third electrode, and an electrical field through tissue of the animal between the second electrode and the third electrode. 9. The apparatus of claim 7, wherein the plurality of electrical conductors includes a third electrical conductor, and wherein the controller is configured to control an electrical voltage between the second electrical conductor and the third electrical conductor. 10. The apparatus of claim 7, wherein the apparatus is configured to be implanted in the animal, and configured such that when the longitudinal axis of the first waveguide bundle is substantially parallel to a longitudinal axis of the first plurality of peripheral nerves of the animal, the electric fields and the optical signals trigger nerve action potentials independently in each of a plurality of the nerves in the nerve bundle. 11. The apparatus of claim 7, wherein the first plurality of waveguides includes a first plurality of optical fibers and the second plurality of waveguides includes a second plurality of optical fibers. 12. The apparatus of claim 11, wherein the first electrode is located near ends of the first plurality of optical fibers, and wherein the second electrode and the third electrode are both located near ends of the second plurality of optical fibers. 13. The apparatus of claim 7, wherein the plurality of laser light sources includes a plurality of vertical-cavity-surface-emitting lasers (VCSELs). 14. The apparatus of claim 7, wherein each of the first plurality of waveguides includes a faceted end configured to transmit its corresponding laser light signal in a direction that is not parallel to the longitudinal axis but is at least partially radially outward from the longitudinal axis. 15. The apparatus of claim 14, wherein the first waveguide bundle is configured such that a face of the faceted end of each of the first plurality of waveguides points in a different direction that is radially-outward and longitudinally angled with respect to the longitudinal axis. 16. The apparatus of claim 14, wherein the first plurality of waveguides and the first waveguide bundle are configured to reflect light out of each of the first plurality of waveguides in a radial direction of the first plurality of waveguides. 17. The apparatus of claim 7, wherein the apparatus is a first optical stimulation device of a plurality of optical stimulation devices including the first optical stimulation device and a second optical stimulation device, wherein laser light signals emitted from the first optical stimulation device onto the first plurality of peripheral nerves is insufficient alone to stimulate a nerve action potential (NAP) in the first plurality of peripheral nerves, and wherein laser light signals from the second optical stimulation device onto the first plurality of peripheral nerves of the patient is insufficient alone to stimulate a NAP in the first plurality of peripheral nerves, but wherein laser light signals from the first optical stimulation device and laser light signals from the second optical stimulation device intersecting onto the first plurality of peripheral nerves deliver a trigger amount of pulsed light sufficient to stimulate a NAP in the first plurality of peripheral nerves. 18. The apparatus of claim 7, wherein the controller is further configured to: selectively control the plurality of electrical conductors to apply a first precharge current of electrical energy across a first volume of tissue,selectively control the plurality of laser light signals to apply a trigger amount of pulsed light to each of a plurality of separate nerves within the first volume of tissue at one or more times following the application of the first precharge current across the first volume of tissue,selectively control the plurality of electrical conductors to apply a second precharge current of electrical energy across a second volume of tissue, separate from the first volume of tissue, andselectively control the plurality of laser light signals to apply a trigger amount of pulsed light to each of a plurality of separate nerves within the second volume of tissue at one or more times following the application of the second precharge current across the second volume of tissue. 19. An apparatus comprising: a computer-readable non-transitory memory having a stored mapping of stimulation signals to responses stored therein;a plurality of laser light sources operatively coupled to the computer-readable memory and configured to generate a plurality of independently controlled laser light signals from selected ones of the plurality of laser light sources based on the stored mapping;a plurality of concentric waveguide bundles including a first waveguide bundle having a first length, and a second waveguide bundle having second length and arranged to encircle the first waveguide bundle, wherein the plurality of waveguide bundles is operatively coupled to the plurality of laser light sources,wherein the plurality of waveguide bundles is configured to emit the plurality of laser light signals toward a first plurality of peripheral nerves of an animal in order to independently optically stimulate selected ones of the first plurality of peripheral nerves of the animal,wherein the first length is not equal to the second length, andwherein the plurality of concentric waveguide bundles is configured to be fully implanted in the animal;means for delivering the plurality of independently controlled laser light signals through the plurality of waveguide bundles to the first plurality of peripheral nerves of the animal in order to independently and separately optically stimulate the first plurality of peripheral nerves of the animal;means for selectively controlling selected ones of the plurality of independently controlled laser light signals emitted from selected ones of the first and second plurality of waveguides wherein the means for selectively controlling the plurality of laser light signals provides controlled optical stimulation to the selected ones of the first plurality of peripheral nerves of the animal that independently triggers action potentials in the selected ones of the first plurality of peripheral nerves; andmeans for creating an electric field across a volume of tissue of the animal, wherein the means for creating the electric field extends along the first waveguide bundle, and wherein the means for creating the electric field is operatively coupled to the means for selectively controlling. 20. The apparatus of claim 19, wherein the plurality of laser light sources includes a plurality of vertical-cavity-surface-emitting lasers (VCSELs).
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