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| 국가/구분 | United States(US) Patent 등록 |
|---|---|
| 국제특허분류(IPC7판) |
|
| 출원번호 | US-0631780 (2012-09-28) |
| 등록번호 | US-8865249 (2014-10-21) |
| 발명자 / 주소 |
|
| 출원인 / 주소 |
|
| 대리인 / 주소 |
|
| 인용정보 | 피인용 횟수 : 0 인용 특허 : 356 |
The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observab
The invention provides an implantable membrane for regulating the transport of analytes therethrough that includes a matrix including a first polymer; and a second polymer dispersed throughout the matrix, wherein the second polymer forms a network of microdomains which when hydrated are not observable using photomicroscopy at 400× magnification or less. In one aspect, the homogeneous membrane of the present invention has hydrophilic domains dispersed substantially throughout a hydrophobic matrix to provide an optimum balance between oxygen and glucose transport to an electrochemical glucose sensor.
1. A method for preparing an implantable membrane for an implantable glucose sensor, the method comprising: forming a composition including a dispersion of a first polymer within a matrix of a second polymer;maintaining the composition at a temperature sufficient to maintain solubility;applying the
1. A method for preparing an implantable membrane for an implantable glucose sensor, the method comprising: forming a composition including a dispersion of a first polymer within a matrix of a second polymer;maintaining the composition at a temperature sufficient to maintain solubility;applying the composition at the temperature to at least one of a substrate or a layer on the substrate to form a film thereon, wherein the step of maintaining the composition precedes the step of applying the composition; anddrying the film to form a membrane configured to cover at least a portion of an electrode of the implantable glucose sensor, wherein the membrane is configured to allow passage of glucose therethrough;whereby after a sample of the membrane is hydrated for two hours the sample membrane exhibits no observable hydrated domains under photomicroscopy at 400× magnification. 2. The method of claim 1, wherein maintaining the composition at the temperature comprises heating the composition at a temperature of about 70° C. 3. The method of claim 1, wherein drying the film comprises drying at a temperature of from about 120° C. to about 150° C. 4. The method of claim 1, wherein the first polymer is a hydrophobic-hydrophilic copolymer that comprises a hydrophilic component comprising polyethylene oxide. 5. The method of claim 1, wherein the second polymer comprises polyurethane. 6. The method of claim 1, wherein the membrane has an oxygen-to-glucose permeability ratio of approximately 200:1. 7. The method of claim 1, wherein the substrate comprises an electrode. 8. The method of claim 1, wherein the membrane is configured to change a ratio of oxygen to glucose from a concentration ratio in a body fluid to a new ratio in which there is a stoichiometric excess of oxygen in an enzyme layer. 9. The method of claim 1, wherein the layer is an enzyme layer. 10. The method of claim 9, further comprising applying an enzyme on the substrate to form an enzyme layer thereon. 11. A method for preparing an implantable membrane for an implantable glucose sensor, the method comprising: forming a composition including a dispersion of a first polymer within a matrix of a second polymer, wherein the first polymer is a copolymer;maintaining the composition at a temperature sufficient to maintain solubility;applying the composition at the temperature to at least one of a substrate or a layer on the substrate to form a film thereon; anddrying the film to form a membrane configured to cover at least a portion of an electrode of the implantable glucose sensor, wherein the membrane is configured to allow passage of glucose therethrough;whereby after a sample of the membrane is hydrated for two hours the sample membrane exhibits no observable hydrated domains under photomicroscopy at 400× magnification.
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