Systems and methods for assaying an eluate for technetium and molybdenum content
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
H01J-047/00
G01T-001/185
G21F-005/015
출원번호
US-0800248
(2013-03-13)
등록번호
US-8872124
(2014-10-28)
발명자
/ 주소
Graves, Kevin B.
Petrofsky, Bryan S.
Verma, Sumit
출원인 / 주소
Mallinckrodt LLC
대리인 / 주소
Armstrong Teasdale LLP
인용정보
피인용 횟수 :
1인용 특허 :
11
초록▼
A system for assaying an eluate for Technetium-99m and Molybdenum-99 content includes an inner ionization chamber including a well configured to receive the eluate, an outer ionization chamber concentric with the inner ionization chamber, and attenuating material positioned between the inner and out
A system for assaying an eluate for Technetium-99m and Molybdenum-99 content includes an inner ionization chamber including a well configured to receive the eluate, an outer ionization chamber concentric with the inner ionization chamber, and attenuating material positioned between the inner and outer ionization chambers. A computing device is configured to determine a Technetium-99m content of the eluate based on a first current measured in the inner ionization chamber, and determine a Molybdenum-99 content of the eluate based on at least a second current measured in the outer ionization chamber.
대표청구항▼
1. A system for assaying an eluate for Technetium-99m and Molybdenum-99 content, the system comprising: an inner ionization chamber including a well configured to receive the eluate;an outer ionization chamber concentric with the inner ionization chamber;attenuating material positioned between the i
1. A system for assaying an eluate for Technetium-99m and Molybdenum-99 content, the system comprising: an inner ionization chamber including a well configured to receive the eluate;an outer ionization chamber concentric with the inner ionization chamber;attenuating material positioned between the inner and outer ionization chambers;a computing device configured to: determine a Technetium-99m content of the eluate based on a first current measured in the inner ionization chamber; anddetermine a Molybdenum-99 content of the eluate based on at least a second current measured in the outer ionization chamber. 2. The system of claim 1, wherein the outer ionization chamber is a high pressure Xenon gas chamber. 3. The system of claim 1, wherein the attenuating material is made of at least one of tungsten and lead. 4. The system of claim 1, wherein the system is configured to determine the Technetium-99m content and the Molybdenum-99 content of the eluate simultaneously. 5. The system of claim 1, further comprising: a first current measurement device communicatively coupled to the computing device and configured to measure the first current in the inner ionization chamber; anda second current measurement device coupled to the computing device and configured to measure the second current in the outer ionization chamber. 6. The system of claim 5, wherein the first and second current measurement devices are source measurement units (SMUs). 7. The system of claim 1, wherein the computing device is further configured to: calculate a portion of the determined Molybdenum-99 content attributable to 322.41 keV energy from decay of Technetium-99m; andsubtract the calculated portion from the determined Molybdenum-99 content to generate a corrected Molybdenum-99 content. 8. The system of claim 1, wherein the inner and outer ionization chambers are annular. 9. A method for assaying an eluate for Technetium-99m and Molybdenum-99 content, the method comprising: placing the eluate in a well of an inner ionization chamber;measuring a first current in the inner ionization chamber;measuring a second current in an outer ionization chamber, wherein the outer ionization chamber is concentric with the inner ionization chamber and separated from the inner ionization chamber by attenuating material;determining, using a computing device, a Technetium-99m content of the eluate from the first measured current; anddetermining, using the computing device, a Molybdenum-99 content of the eluate from at least the second measured current. 10. The method of claim 9, wherein measuring a second current in an outer ionization chamber comprises measuring a second current in a high pressure Xenon gas chamber. 11. The method of claim 9, further comprising calculating, using the computing device, a ratio of Technetium-99m to Molybdenum-99 in the eluate. 12. The method of claim 9, wherein the Technetium-99m content and the Molybdenum-99 content of the eluate are determined simultaneously. 13. The method of claim 9, wherein measuring a first current comprises measuring the first current using a first source measurement unit, and wherein measuring a second current comprises measuring the second current using a second source measurement unit. 14. The method of claim 9, further comprising: calculating, using the computing device, a portion of the determined Molybdenum-99 content attributable to 322.41 keV energy from decay of Technetium-99m; andsubtracting, using the computing device, the calculated portion from the determined Molybdenum-99 content to generate a corrected Molybdenum-99 content. 15. A radiation detection device for detecting a plurality of radioactive isotopes in an eluate, the radiation detection device comprising: an inner ionization chamber including a well that receives the eluate, wherein a first current is generated in the inner ionization chamber in response to a first radioactive isotope present in the eluate;an outer ionization chamber concentric with the inner ionization chamber, wherein a second current is generated in the outer ionization chamber in response to a second radioactive isotope present in the eluate; andattenuating material positioned between the inner and outer ionization chambers. 16. The radiation detection device of claim 15, wherein the first radioactive isotope is Technetium-99m and the second radioactive isotope is Molybdenum-99. 17. The radiation detection device of claim 15, wherein the outer ionization chamber is a high pressure Xenon gas chamber. 18. The radiation detection device of claim 15, wherein the attenuating material is made of at least one of tungsten and lead. 19. The radiation detection device of claim 15, wherein the attenuating material has a thickness of approximately 0.25 inches. 20. The radiation detection device of claim 15, wherein the inner and outer ionization chambers are annular.
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