A delivery apparatus useful for infusing a therapeutic agent into a body lumen, the apparatus including a lumenal body defining at least one infusion port for infusing the therapeutic agent into the body lumen, and a sensing element which is distal of the at least one infusion port and adapted to se
A delivery apparatus useful for infusing a therapeutic agent into a body lumen, the apparatus including a lumenal body defining at least one infusion port for infusing the therapeutic agent into the body lumen, and a sensing element which is distal of the at least one infusion port and adapted to sense the amount of infused therapeutic agent or any compound derived therefrom in the body lumen. Another embodiment of the apparatus includes a lumenal body defining at least one infusion port for infusing the therapeutic agent into the body lumen, and a filtration element which is distal of the at least one infusion port and adapted to deliver a reaction agent which may react with the therapeutic agent in the body lumen. A sensing element may be provided distal of the filtration element for sensing the amount of infused therapeutic agent or compounds derived therefrom in the body lumen.
대표청구항▼
1. An apparatus for infusing a therapeutic agent into a body lumen, the apparatus comprising: a multiple coaxial catheter assembly comprising a first lumenal body;a second lumenal body extending beyond the first lumenal body, said second lumenal body having at least one infusion port for infusing th
1. An apparatus for infusing a therapeutic agent into a body lumen, the apparatus comprising: a multiple coaxial catheter assembly comprising a first lumenal body;a second lumenal body extending beyond the first lumenal body, said second lumenal body having at least one infusion port for infusing the therapeutic agent into the body lumen;a third lumenal body extending beyond the second lumenal body;a sensing element attached to the third lumenal body distal of the at least one infusion port and adapted to sense an amount of infused therapeutic agent or any compound derived from the therapeutic agent in the body lumen;a sensing element signal produced by the sensing element; anda feedback component associated with the sensing element and adapted to provide the sensing element signal to a location outside of the body lumen. 2. The apparatus of claim 1, wherein the feedback component provides the sensing element signal to a user interface. 3. The apparatus of claim 1, wherein the sensing element signal is represented to a user as an audible, visual, or tactile stimulus or a combination stimulus comprising one or more of the audible, visual, and tactile stimuli. 4. The apparatus of claim 1, wherein the sensing element signal is proportional to the amount of infused therapeutic agent or derivative thereof detected by the sensing element. 5. The apparatus of claim 1, wherein the sensing element is adapted to sense the amount of therapeutic agent or derivative thereof by one or more of resonant mass detection, light reflectance, and electrical conductivity changes. 6. The apparatus of claim 1, wherein the sensing element is shaped to correspond to the cross-sectional shape of the body lumen. 7. The apparatus of claim 1, wherein the sensing element is formed as a fine wire mesh. 8. The apparatus of claim 1, wherein the sensing element is formed of electrically conductive material. 9. The apparatus of claim 8, wherein the electrically conductive material is formed as a fine wire mesh adapted to intercept at least some of the therapeutic agent or derivative thereof in the body lumen. 10. The apparatus of claim 8, wherein the electrically conductive material changes conductivity when exposed to the therapeutic agent or derivative thereof. 11. An apparatus for infusing a therapeutic agent into a body lumen, the apparatus comprising: a multiple coaxial catheter assembly comprising a first lumenal body;a second lumenal body extending beyond the first lumenal body, the second lumenal body having at least one infusion port for infusing the therapeutic agent into the body lumen;a third lumenal body extending beyond the second lumenal body;a sensing element attached to the third lumenal body;a filtration element distal of the at least one infusion port and adapted to deliver a reaction agent which is adapted to react with the therapeutic agent in the body lumen;a chemical coating on the filtration element; anda sensing element signal produced by the sensing element,wherein the sensing element is adapted to sense an amount of infused therapeutic agent or any compound derived from the therapeutic agent in response to the reaction agent in the body lumen. 12. The apparatus of claim 11, wherein the filtration element comprises a plurality of radially expandable structures secured to the third lumenal body. 13. The apparatus of claim 11, wherein the filtration element is in the form of at least one distal infusion port disposed on the third lumenal body. 14. The apparatus of claim 13, wherein the sensing element is distal of the at least one distal infusion port. 15. The apparatus of claim 11, further comprising a feedback component associated with the sensing element and adapted to provide the sensing element signal to a location outside of the body lumen. 16. The apparatus of claim 15, wherein the feedback component is adapted to communicate wirelessly with a user interface located outside of the body lumen. 17. The apparatus of claim 15, wherein the feedback component provides the sensing element signal to a user interface. 18. The apparatus of claim 15, wherein the sensing element signal is represented to a user as an audible, visual, or tactile stimulus or a combination stimulus comprising one or more of an audible, visual, and tactile stimuli. 19. The apparatus of claim 15, wherein the sensing element signal is proportional to the amount of infused therapeutic agent or derivative thereof sensed by the sensing element. 20. The apparatus of claim 11, wherein the sensing element is adapted to sense the amount of infused therapeutic agent or derivative thereof by one or more of resonant mass detection, light reflectance, and electrical conductivity changes. 21. The apparatus of claim 11, wherein the sensing element is formed as a fine wire mesh. 22. The apparatus of claim 11, wherein the sensing element is formed of electrically conductive material. 23. The apparatus of claim 22, wherein the electrically conductive material is formed as a fine wire mesh adapted to intercept at least some of the infused therapeutic agent or derivative thereof in the body lumen. 24. The apparatus of claim 22, wherein the electrically conductive material changes conductivity when exposed to the infused therapeutic agent or derivative thereof. 25. A multiple coaxial catheter assembly comprising: a first lumenal body;a second lumenal body extending beyond the first lumenal body, the second lumenal body having at least one infusion port for infusing a therapeutic agent into a body lumen;a third lumenal body extending beyond the second lumenal body; anda sensing element attached to the third lumenal body used to deliver the therapeutic agent to the body lumen, the sensing element comprising an electrically conductive body adapted to change conductivity when exposed to the therapeutic agent or any compound derived from the therapeutic agent. 26. The catheter assembly of claim 25, wherein the electrically conductive body is in the form of an electrically conductive fine wire mesh. 27. The catheter assembly of claim 25, wherein the electrically conductive body is shaped to correspond to a cross-sectional shape of the body lumen. 28. The catheter assembly of claim 25, wherein the sensing element further comprises a feedback component adapted to provide a sensing element signal to a location outside of the body lumen. 29. The catheter assembly of claim 28, wherein the sensing element further comprises a user interface coupled to the feedback component for receiving the sensing element signal. 30. The catheter assembly of claim 29, wherein the user interface is adapted to represent the sensing element signal to a user as an audible, visual, or tactile stimulus or a combination stimulus comprising one or more of the audible, visual, and tactile stimuli. 31. The catheter assembly of claim 28, wherein the sensing element signal is proportional to an amount of therapeutic agent or derivative thereof sensed by the sensing element. 32. The catheter assembly of claim 25, wherein the sensing element is adapted to sense a combination of the therapeutic agent and a reaction agent adapted to react with the therapeutic agent. 33. A multiple coaxial catheter assembly comprising: a first lumenal body;a second lumenal body extending beyond the first lumenal body, the second lumenal body having at least one infusion port for infusing a therapeutic agent into a body lumen;a third lumenal body extending beyond the second lumenal body; anda filtration element attached to the third lumenal body used to deliver the therapeutic agent to the body lumen, the filtration element comprising a plurality of structures coated with a reaction agent adapted to react with the therapeutic agent. 34. The catheter assembly of claim 33, wherein the plurality of coated structures are radially expandable structures secured to the third lumenal body.
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