A prosthesis is provided for implantation at a native semilunar valve of a native valve complex. The prosthesis includes a distal fixation member, configured to be positioned in a downstream artery, and to apply a first axial force directed toward a ventricle. The prosthesis further includes a proxi
A prosthesis is provided for implantation at a native semilunar valve of a native valve complex. The prosthesis includes a distal fixation member, configured to be positioned in a downstream artery, and to apply a first axial force directed toward a ventricle. The prosthesis further includes a proximal fixation member coupled to the distal fixation member, the proximal fixation member configured to be positioned at least partially on a ventricular side of the native valve complex, and to apply a second axial force directed toward the downstream artery, such that application of the first and second forces couples the prosthesis to the native valve complex by axially sandwiching the native valve complex from a downstream side and the ventricular side thereof. The prosthesis is configured, upon implantation thereof, to embrace, without squeezing, leaflets of the native semilunar valve. Other embodiments are also described.
대표청구항▼
1. Apparatus comprising a prosthesis for implantation at a native semilunar valve of a native valve complex of a subject, the prosthesis comprising: a distal fixation member including exactly three engagement arms, wherein each of the engagement arms is configured to extend into a respective sinus o
1. Apparatus comprising a prosthesis for implantation at a native semilunar valve of a native valve complex of a subject, the prosthesis comprising: a distal fixation member including exactly three engagement arms, wherein each of the engagement arms is configured to extend into a respective sinus of a heart when the prosthesis is implanted in a native valve complex, wherein the distal fixation member has an upstream end and a downstream end, the upstream end being configured to be positioned closer to a ventricle of a subject when the prosthesis is implanted in a subject, and wherein the distal fixation member is configured to apply a first axial force directed toward a ventricle of the subject;a proximal fixation member coupled to the distal fixation member, the proximal fixation member configured to be positioned at least partially on a ventricular side of a native valve complex, and to apply a second axial force directed toward the downstream artery, such that application of the first and second forces couples the prosthesis to the native valve complex by axially sandwiching the native valve complex from a downstream side and the ventricular side thereof; anda replacement cardiac valve, wherein the replacement cardiac valve includes commissures, and wherein the commissures are attached to the downstream end of the distal fixation member. 2. The apparatus according to claim 1, wherein the prosthesis is configured, upon implantation thereof, to gently embrace, without squeezing, leaflets of a native semilunar valve. 3. The apparatus according to claim 1, wherein the distal fixation member is configured to be positioned in an ascending aorta. 4. The apparatus according to claim 1, wherein the distal fixation member is configured to be positioned in a pulmonary trunk. 5. The apparatus according to claim 1, wherein the prosthesis is configured such that any radial force applied by the prosthesis outwardly against a native semilunar valve is insufficient by itself to chronically maintain the prosthesis in position with respect to a native valve complex under conditions of normal cardiac motion. 6. The apparatus according to claim 1, wherein the prosthesis is configured to apply the first axial force such that a ratio of (a) the first axial force to (b) a radial force applied outwardly by the prosthesis against a native semilunar valve is greater than 1.5:1. 7. The apparatus according to claim 1, wherein the prosthesis is configured to apply the second axial force such that a ratio of (a) the second axial force to (b) a radial force applied outwardly by the prosthesis against a native semilunar valve is greater than 1.5:1. 8. The apparatus according to claim 1, wherein the prosthesis is configured to apply a radial force of less than 0.5 pounds outwardly against a native semilunar valve. 9. The apparatus according to claim 1, wherein the distal fixation member does not press upon native valve commissures of a native semilunar valve upon implantation of the prosthesis. 10. The apparatus according to claim 1, wherein the prosthesis is configured to apply the first axial force with a force of at least 40 g during diastole. 11. The apparatus according to claim 1, wherein the prosthesis is configured to apply the second axial force with a force of at least 1 g during systole. 12. The apparatus according to claim 1, wherein the prosthesis is configured to apply the second axial force with a force of at least 5 g during systole. 13. The apparatus according to claim 1, wherein the distal fixation member is configured such that it does not fold over leaflets of a native semilunar valve upon implantation of the prosthesis. 14. The apparatus according to claim 1, wherein the prosthesis is configured to less than fully open leaflets of a native valve complex when the prosthesis is implanted at the native valve complex. 15. The apparatus according to claim 1, wherein the replacement cardiac valve is configured to assume a closed position during diastole and an open position during systole. 16. The apparatus according to claim 15, wherein the replacement cardiac valve comprises a collapsible pliant material, configured to assume the open and closed positions. 17. The apparatus according to claim 15, wherein the distal and proximal fixation members and the replacement cardiac valve are configured to define a single flow field through the distal and proximal fixation members and the replacement cardiac valve. 18. The apparatus according to claim 15, wherein the distal and proximal fixation members and the replacement cardiac valve are configured to define a plurality of flow fields through the distal and proximal fixation members and the replacement cardiac valve. 19. The apparatus according to claim 15, wherein the replacement cardiac valve comprises one or more prosthetic leaflets, and wherein the replacement cardiac valve is coupled to the prosthesis such that at least 50% of an axial length of the prosthetic leaflets is distal to native valve leaflets of a native semilunar valve upon implantation of the prosthesis.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (305)
Yock Paul G. (1216 San Mateo Dr. Menlo Park CA 94025), Angioplasty apparatus facilitating rapid exchanges.
Barbut, Denise; Root, Jonathan D.; Pastrone, Giovanni; Maahs, Tracy D.; Tsugita, Ross S., Aortic occluder with associated filter and methods of use during cardiac surgery.
Taheri Syde (268 Dan Troy Williamsville NY 14221) Leonhardt Howard J. (13794 NW. 4th St. ; Bldg. #210 Sunrise FL 33325), Apparatus and method for engrafting a blood vessel.
Lenker Jay A. ; Freislinger Kirsten ; Evans Michael A. ; Watanabe Gwendolyn A. ; Ryan Timothy J. ; Zarins Christopher K. ; Murphy Richard O., Apparatus and methods for placement and repositioning of intraluminal prostheses.
Paul F. Chouinard ; Dennis A. Peiffer ; Patrick A. Haverkost, Braided branching stent, method for treating a lumen therewith, and process for manufacture therefor.
White, Bradley R.; Chouinard, Paul F.; Peiffer, Dennis A.; Haverkost, Patrick A., Braided, branched, implantable device and processes for manufacture thereof.
Roberts George T. (Weston MA) Hess Kathleen L. (Lynn MA) Nott Sepideh H. (Canton MA) Chu Michael S. H. (Brookline MA) Chin Yem (Burlington MA), Controlled deployment of a medical device.
Liotta Domingo S. (3 De Febrero 2025 Buenos Aires ARX) Troncoso De Liotta Holga E. (3 De Febrero 2025 Buenos Aires ARX 1428), Diaphragm and method for occlusion of the descending thoracic aorta.
Tchakarov Borislav J. ; DiFoggio Rocco ; Forgang Stanislav W. ; Fanini Otto N. ; Hunziker James C. ; Civarolo Marcelo F., Downhole carbon dioxide gas analyzer.
Julio C. Palmaz ; Eugene A. Sprague ; Cristina Simon ; Denes Marton ; Roger W. Wiseman ; Christopher E. Banas, Endoluminal device exhibiting improved endothelialization and method of manufacture thereof.
Valley, Kirsten L.; Snow, David W.; Corvi, Timothy C.; Donlon, Brian S.; Boyd, Stephen W.; Fan, Sylvia W.; Roth, Alex T.; Peters, William S.; Mueller, Jr., Richard J.; Gifford, III, Hanson S., Endovascular system for arresting the heart.
Suh Soo Won,KRX ; Kim In Young,KRX ; Choo In Wook,KRX ; Do Young Soo,KRX ; Choo Sung Wook,KRX, Flexible self-expandable stent and method for making the same.
Carpentier Alain (Paris FRX) Carpentier Sophie (Paris CA FRX) Nashef Aws S. (Costa Mesa CA), Implantable biological tissue and process for preparation thereof.
Carpentier Alain (Paris FRX) Carpentier Sophie (Paris CA FRX) Nashef Aws S. (Costa Mesa CA), Implantable biological tissue and process for preparation thereof.
Block Peter C. (3510 SW. Sherwood Pl. Portland OR 97201) Anderson W. Earl (230 E. 38th Ave. Eugene OR 97405-4714) Atteridge David G. (18235 SW. Barcelona Way Beaverton OR 97007), Inflatable prosthetic cardiovascular valve for percutaneous transluminal implantation of same.
Williamson ; IV Warren ; Spence Paul A. ; Christakis George T.,CAX ; Ward Thomas J. ; DiNovo Dominic P. ; Keller George A. ; Robinson Cecil R. ; VanHoose E. Dale, Means and method of replacing a heart valve in a minimally invasive manner.
Garrison Michi E. ; Donlon Brian S. ; Mueller ; Jr. Richard L., Method and apparatus for minimizing the risk of air embolism when performing a procedure in a patient's thoracic cavity.
Liddicoat, John R.; Lambrecht, Gregory H.; Davenport, Todd F.; Cohn, William E.; Woolfson, Steven B.; Taylor, Daniel C., Method and apparatus for performing a procedure on a cardiac valve.
Stenzel, Eric B.; Sahatjian, Ronald A.; Zhong, Sheng-ping; Dao, Kinh-Luan D.; Dayton, Peter L.; Kalashian, Daniel J.; Griffin, Stephen; Chien, Thomas Yung-hui, Method and device for providing full protection to a stent.
Nguyen Than (Huntington Beach CA) Nashef Aws (Huntington Beach CA) Abolfathi Amir H. (Laguna Hills CA) Wieting David W. (Irvine CA) Lee Denis (Irvine CA), Method and device for testing venous valves.
Nguyen Than (Huntington Beach CA) Nashef Aws (Huntington Beach CA) Abolfathi Amir H. (Laguna Hills CA) Wieting David W. (Irvine CA) Lee Denis (Irvine CA), Method for testing venous valves.
Yang, Jibin; Heneveld, Sr., Scott Hyler; Pease, Matthew Lane; Walsh, Brandon G., Methods and apparatuses for deploying minimally-invasive heart valves.
Zadno-Azizi Gholam-Reza ; Luehrs Kirsten F. ; Gittings Darin C. ; Turovskiy Roman ; Cox Brian J. ; Shiu Brian ; Hayes Michael B. ; Coombs Craig J., Methods for the manufacture of radially expansible stents.
Hachtman Steven W. (Chanhassen MN) Johnson Liann M. (Golden Valley MN) Johnson Scott T. (Anoka MN) Laptewicz ; Jr. Joseph E. (Eden Prairie MN) Thompson Paul J. (New Hope MN) Ahmad Amjad (Eagan MN) Sc, Multiple layer stent.
Cribier Alain (Maromme FRX) Letac Brice (Rouen RI FRX) Ariola ; Jr. John P. (East Providence RI), Procedure and catheter instrument for treating patients for aortic stenosis.
Bokros Jack C. ; Ely John L. ; Emken Michael R. ; Haubold Axel D. ; Peters T. Scott ; Stupka Jonathan C. ; Waits C. Thomas, Prosthetic heart valve with improved blood flow.
Quijano R. C. (Laguna Hills CA) Nashef Aws (Huntington Beach CA), Stent devices and support/restrictor assemblies for use in conjunction with prosthetic vascular grafts.
Ross Donald N. (25 Upper Wimpole St. London W.1 GB2) Bodnar Endre (9 West End Ct. ; West End Ave. Pinner ; Middlesex GB2) Hoskin William J. (5 Long Buftlers Harpenden ; Hertfordshire GB2), Stent for a cardiac valve.
An Sung Soon,KRX ; Kim Chel Seng,KRX ; Choi Sung Pil,KRX ; Kim Tae Hyung,KRX ; Song Ho Young,KRX ; Song Sang Woo,KRX, Stent for expanding body's lumen.
McVenes Rick D. (Isanti MN) Stokes Kenneth B. (Brooklyn Park MN) Pohndorf Peter J. (Stillwater MN) Proctor Keith J. (Lino Lakes MN), Steroid eluting stitch-in chronic cardiac lead.
Stevens John H. (Palo Alto CA) Sterman Wesley D. (San Francisco CA) Gifford ; III Hanson S. (Woodside CA) Machold Timothy R. (Moss Beach CA), System for cardiac procedures.
Sabbaghian Mehdy (Baton Rouge LA) Dailey Russell S. (Metairie LA) Dobson Gregory T. (Baton Rouge LA) Tang Hing W. (Perak LA MYX) Schwartzberg Glen J. (Baton Rouge LA), Valve cutter for arterial by-pass surgery.
Andersen, Henning Rud; Hasenkam, John Michael; Knudsen, Lars Lyhne, Valve prosthesis for implantation in the body and a catheter for implanting such valve prosthesis.
Andersen Henning R. (Dalvangen 37A DK-8270 Hoejbjerg DKX) Hasenkam John M. (Aprilvej 8 DK-8210 Aarhus V DKX) Knudsen Lars L. (RudolfWulffsgade 6,4.mf. DK-8000 Aarhus C DKX), Valve prothesis for implantation in the body and a catheter for implanting such valve prothesis.
Palmaz,Julio C.; Sprague,Eugene A.; Fuss,Cristina; Marton,Denes; Wiseman,Roger W.; Banas,Christopher E.; Boyle,Christopher T.; Bailey,Steven R., Valvular prostheses having metal or pseudometallic construction and methods of manufacture.
Braido, Peter N.; Ashworth, Paul E.; Schraut, Julia A., Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications.
Braido, Peter N.; Ashworth, Paul Edward; Schraut, Julia Ann, Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications.
Braido, Peter N.; Ashworth, Paul Edward; Schraut, Julia Ann, Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications.
Braido, Peter N.; Ashworth, Paul Edward; Schraut, Julia Ann, Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications.
Braido, Peter N.; Ashworth, Paul Edward; Schraut, Julia Ann, Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications.
Braido, Peter N.; Ashworth, Paul Edward; Schraut, Julia Ann, Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications.
Braido, Peter Nicholas; Ashworth, Paul Edward; Schraut, Julia Ann, Collapsible and re-expandable prosthetic heart valve cuff designs and complementary technological applications.
Braido, Peter N.; Alkhatib, Yousef F.; Anderl, Steven Frederick; Daly, Jacob John; Fahim, Mina S.; Smith, Kent J.; Thomas, Ralph J., Paravalvular sealing via extended cuff mechanisms.
Braido, Peter N.; Smith, Kent J.; McCarthy, Andrea L.; Fahim, Mina S., Stationary intra-annular halo designs for paravalvular leak (PVL) reduction—active channel filling cuff designs.
Braido, Peter N.; Smith, Kent J.; McCarthy, Andrea L.; Para, Andrea N.; Khouengboua, Sounthara (Ott); Benson, Thomas M.; Kumar, Saravana B.; Moseman, Bruce; Satam, Gaurav, Subannular sealing for paravalvular leak protection.
Morin, Kristen T.; Para, Andrea N.; Braido, Peter N.; Khouengboua, Sounthara; Benson, Thomas M.; Kumar, Saravana B.; Moseman, Bruce; Satam, Gaurav, Transcatheter valve with paravalvular leak sealing ring.
Morin, Kristen T.; Para, Andrea N.; Braido, Peter N.; Khouengboua, Sounthara; Benson, Thomas M.; Kumar, Saravana B.; Moseman, Bruce; Satam, Gaurav, Transcatheter valve with paravalvular leak sealing ring.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.