Systems include test cells with sorbent material in a T-shape and defining a first flow path for a solution and a second flow path for a sample, and a test line or test site with immobilized antigens or antibodies or other ligand binding molecules located at the junction of the T. A housing houses t
Systems include test cells with sorbent material in a T-shape and defining a first flow path for a solution and a second flow path for a sample, and a test line or test site with immobilized antigens or antibodies or other ligand binding molecules located at the junction of the T. A housing houses the sorbent material and defines a first hole adjacent an end of the first flow path for receiving the solution and a second hole adjacent an end of the second flow path for receiving the sample.
대표청구항▼
1. A test device for use with a solution and for determining the presence of a ligand in a liquid sample, the test device comprising: a) one or more sorbent strips laid out in a “T” configuration with a test site located at the junction of the “T”, said test site having an immobilized ligand-binding
1. A test device for use with a solution and for determining the presence of a ligand in a liquid sample, the test device comprising: a) one or more sorbent strips laid out in a “T” configuration with a test site located at the junction of the “T”, said test site having an immobilized ligand-binding mechanism;b) a conjugate having a marker located along and supported by a first leg of the “T”;c) a housing surrounding said one or more sorbent strips, said housing defining a first opening adjacent a first end of said first leg of the “T” configuration, said first opening adapted to receive the solution to cause said conjugate to laterally migrate over time along said first leg to said test site, and said housing defining a second opening adjacent a first end of a second leg of the “T”, said second opening adapted to receive the sample which can laterally migrate over time along said second leg which is perpendicular to said first leg to said test site, and said housing defining a window adjacent said test site through which said test site is viewable. 2. A test device according to claim 1, wherein: said first opening and said second opening are equidistant said window. 3. A test device according to claim 1, wherein: said ligand-binding mechanism is an antigen or antibody for said ligand, and said conjugate comprises an antigen or antibody for the ligand and said marker coupled to the antigen or antibody. 4. A test device according to claim 3, wherein: said marker is a colored marker viewable in the visible spectrum. 5. A test device according to claim 1, wherein: said one or more sorbent strips includes a control site, and said housing defines a window for viewing said control site. 6. A test device according to claim 1, further comprising: said solution, wherein said solution comprises a buffer. 7. A test device according to claim 1, wherein: said immobilized ligand-binding mechanism comprises an HIV antigen or antibody. 8. A test device according to claim 1, wherein: said test device is for determining the presence of a plurality of different ligands in the liquid sample, andsaid test site has a plurality of separate immobilized ligand-binding mechanisms for separately binding to respective of said plurality of different ligands. 9. A test device according to claim 8, wherein: said plurality of separate immobilized ligand-binding mechanisms includes a tuberculosis antigen and at least one HIV antigen. 10. A test device according to claim 8, wherein: said plurality of separate immobilized ligand-binding mechanisms includes p24 antibodies and at least one of an HIV1 and an HIV2 antigen. 11. A method for testing a sample for the presence of a ligand, comprising: a) obtaining solution and a test device having (i) one or more sorbent strips laid out in a “T” configuration with a test site located at the junction of the “T”, said test site having an immobilized ligand-binding mechanism;(ii) a conjugate having a marker located along and supported by a first leg of the “T”;(iii) a housing surrounding said one or more sorbent strips, said housing defining a first opening adjacent a first end of said first leg of the “T” configuration, said first opening adapted to receive the solution to cause said conjugate to laterally migrate over time along said first leg to said test site, and said housing defining a second opening adjacent a first end of a second leg of the “T”, said second opening adapted to receive the sample which can laterally migrate over time along said second leg which is perpendicular to said first leg to said test site, and said housing defining a window adjacent said test site through which said test site is viewable;b) applying the sample through the second opening to the second leg;c) after said applying the sample, applying the solution through the first opening to the first leg; andd) inspecting said test site through said window to determine an indication of the presence or lack thereof of the ligand in the sample. 12. A method according to claim 11, wherein: said one or more sorbent strips includes a control site, and said method further comprises inspecting said control site to determine an indication of the validity of testing. 13. A method according to claim 11, wherein: said test device is for determining the presence of a plurality of different ligands in the liquid sample, and said test site has a plurality of separate immobilized ligand-binding mechanisms for separately binding to respective of said plurality of different ligands, and said inspecting said test site comprises inspecting to determine an indication of the presence or lack thereof of each of said plurality of different ligands. 14. A method according to claim 13, wherein: said plurality of separate immobilized ligand-binding mechanisms are arranged in a plurality of separate lines, and said inspecting said test site comprises looking for the presence of colored lines.
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이 특허에 인용된 특허 (303)
Barnwell John W. (New York NY), Plasmodium vivax blood stage antigens, PvESP-1, antibodies, and diagnostic assays.
Goerlach-Graw Ada (Weisenheim am Sand DEX) Naegele Ulrich (Weinheim DEX) Wilk Hans-Erich (Einhausen DEX) Graw Reiner (Weisenheim am Sand DEX), Analysis element and method for determination of an analyte in a liquid sample.
Baugher Bennett W. (Waukegan IL) Chamberlain Aurora J. (Buffalo Grove IL) Devereaux Sharon M. (Gurnee IL) Ungemach Frank S. (Lake Villa IL), Analyte-substitute reagent for use in specific binding assay methods, devices and kits.
Baugher Bennett W. (Waukegan IL) Chamberlain Aurora J. (Buffalo Grove IL) Devereaux Sharon M. (Gurnee IL) Ungemach Frank S. (Lake Villa IL), Analyte-substitute reagent for use in specific binding assay methods, devices and kits.
Moorman David R. (Indianapolis IN) Ledden David J. (Indianapolis IN) Webster David D. (Indianapolis IN) Heald Brian A. (Indianapolis IN), Analytical test apparatus with on board negative and positive control.
Gribnau Thomas C. J. (Haren NLX) Roeles Frits (Dreumel NLX) Leuvering Johannes H. W. (Heesch NLX), Application of water-dispersible hydrophobic dyes or pigments as labels in immunoassays.
Pronovost Allan D. (San Diego CA) Bacquet Cathy A. (Encinitas CA) Pawlak Jan W. (Cardiff-by-the Sea CA) Sand Theodore T. (Poway CA), Assay device for one step detection of analyte.
Nowakowski Mark R. ; Buechler Kenneth F. ; Anderson Richard R. ; Valkirs Gunars E., Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network.
Nowakowski Mark R. ; Buechler Kenneth F. ; Anderson Richard R. ; Valkirs Gunars E., Assay devices comprising a porous capture membrane in fluid-withdrawing contact with a nonabsorbent capillary network.
Albarella James P. (Granger IN) Michaels Angela A. (Elkhart IN) Pugia Michael J. (Granger IN) Sommer Ronald G. (Elkhart IN), Assay for the determination of protein in a biological sample.
May Keith (Bedfordshire GB2) Prior Michael E. (Northamptonshire GB2) Richards Ian (Bedford GB2), Capillary immunoassay and device therefor comprising mobilizable particulate labelled reagents.
Gordon Julian (Lake Bluff IL) McMahon Michael E. (Libertyville IL) Ching Shanfun (Vernon Hills IL), Chromatographic test strip for determining ligands or receptors.
Weng Litai (Mountain View CA) Calderhead David (Menlo Park CA) Khanna Pyare (San Jose CA) Ullman Edwin F. (Atherton CA), Concentrating immunochemical test device and method.
Boehringer Hans R. (San Diego CA) Sabran Jan L. (San Diego CA) Hsu Ya-Chen (Encinitas CA) Tam Bentley (San Diego CA), Controlled sensitivity immunochromatographic assay.
Scott M. Clark ; Robert H. Suva ; Michael R. Kepron ; Stanislaw Barski, Jr. ; Erwin F. Workman, Jr., Device and method for integrated diagnostics with multiple independent flow paths.
Marchand Joseph (Verrieres Le Buisson FRX) Toledano Jacques (Paris FRX), Device and method for the rapid qualitative and quantitative determination of the presence of a reactive ligand in a flu.
Douglas Joel S. ; Radwanski Ryszard ; Duchon Brent G. ; Priest John H. ; Hasker David A. ; Gleisner John M., Device for determination of an analyte in a body fluid.
Douglas Joel S. ; Radwanski Ryszard ; Duchon Brent G. ; Priest John H. ; Hasker David A. ; Gleisner John M., Device for determination of an analyte in a body fluid.
Douglas, Joel S.; Radwanski, Ryszard; Duchon, Brent G.; Priest, John H.; Hasker, David A.; Gleisner, John M., Device for determination of an analyte in a body fluid.
Skold Carl N. (Mountain View CA) Shanafelt Armen B. (Redwood City CA) Ghazarossian Vartan (Menlo Park CA) Ullman Edwin F. (Atherton CA), Device for immunochromatographic analysis.
Bogart Gregory R. (Berthoud CO) Moddel Garret R. (Boulder CO) Maul Diana M. (Thornton CO) Etter Jeffrey B. (Boulder CO), Devices and methods for detection of an analyte based upon light interference.
Miller B. John (Boulder CO) Maul Diana M. (Thornton CO) Blessing James (Boulder CO) Crosby Mark (Niwot CO) Kelley Howard (Boulder CO), Devices for detection of an analyte based upon light interference.
Jou Yi-Her (Libertyville IL) Stroupe Stephen D. (Libertyville IL) Markese James J. (Libertyville IL), Devices for performing ion-capture binding assays.
Chu Albert E. (140 Roblar Ave. Hillsborough CA 94010) Chun Peter K. (2566 Adams Ct. ; So. South San Francisco CA 94080) Yeung Siu Chin C. (36 Ottawa St. San Mateo CA 94401), Elongated membrane flow-through diagnostic device and method.
Kortright Kenneth H. (Cooper City FL) Hofheinz David E. (Homestead FL) Forman Meryl A. (Miami FL) Lee Song Y. (Plantation FL) Smariga Paulette E. (N. Miami FL) Stoner Candie S. (Hollywood FL), Enzyme immunoassay for detecting HIV antigens in human sera.
Klepp, Jurgen; Hiller, Gerhard; Nichtl, Alfons; Fischer, Ulrike; Hosch, Martina, General purpose structure of an analytical element and its application for analyte determination.
Weinstein David E. (1622 Myrtle Ave. San Diego CA 92103) Kilpatrick Trevor J. (8750 Villa La Jolla Dr. ; Apt. 67 La Jolla CA 92037), HIV test kit method for detecting anti-HIV-I antibodies in saliva.
Kalra Krishan L. (Moraga CA) Pawlak Katarzyna (Oakland CA) Moon Patricia A. (San Ramon CA) French Larry D. (Oakland CA), Immunoassay test device and method.
Eisinger Robert W. (San Diego CA) Khalil Mohammed H. (San Diego CA) Katz David H. (La Jolla CA) Sargeant Robert B. (Ramona CA), Lateral flow, non-bibulous membrane assay protocols.
McGeehan John K. (Woodbury NJ) Ertingshausen Gerhard (Princeton NJ) Meluch Timothy B. (Bear DE), Manufacturing process for sample initiated assay device.
Hubscher Thomas T. (18912 Glendower Rd. Gaithersburg MD 20879), Method and apparatus for performing determinations of immune rectants in biological fluids.
Katamine Tomoaki (Urawa JPX) Sato Hiroshi (Kitakatsushika JPX) Mochida Ei (Tokyo JPX), Method and device for measuring a target substance in a liquid sample.
El Shami A. Said (Agoura Hills CA) Hand Christopher W. (Freeland GB2) Miller Susan A. (Witney GB2) Moore Robert A. (Noke GB2), Method and element for measuring analytes in biological fluids using immobilized binder-analyte labeled complex.
Reckel Rudolph P. (Bridgewater NJ) Harris Joanne L. (Annandale NJ) Wellerson ; Jr. Ralph (Basking Ridge NJ) Shaw Sally M. (Somerville NJ) Kaplan Paul M. (Sergeantsville NJ), Method for detecting immune complexes in serum.
Buck Harvey (Indianapolis IN), Method for determining an analyte in a liquid sample using a zoned test device and an inhibitor for a label used in said.
Hubscher, Thomas T.; Ford, Glen M; Ruppenthal, Teri M, Method for the visual detection of specific antibodies in human serum by the use of lateral flow assays.
Ness Jeffrey Van ; Tabone John C. ; Howbert J. Jeffry ; Mulligan John T., Methods and compositions for enhancing sensitivity in the analysis of biological-based assays.
Bogart Gregory R. (Berthoud CO) Moddel Garret R. (Boulder CO) Maul Diana M. (Thornton CO) Etter Jeffrey B. (Boulder CO) Crosby Mark (Niwot CO), Methods for detection of an analyte.
Jorgen Schjerning Lundsgaard DK; David Morgan Thomas DK; Torsten Bjoern DK, Multi-sectioned fluid delivery devices for detecting target molecules by immunoassay.
Greenquist Alfred C. (Elkhart IN) Li Thomas M. (Elkhart IN) Rupchock Patricia A. (Elkhart IN) Tyhach Richard J. (Elkhart IN) Walter Bert (South Bend IN), Multilayer homogeneous specific binding assay device.
Fitzgerald, Daniel; Chandler, Howard M.; LaPointe, Larry, Opposable-element chromatographic assay device for detection of analytes in whole blood samples.
Moore, Norman James; Fent, Mary Kathleen; Koulchin, Vladimir Andrei; Molokova, Elena Valentin, Process and materials for the rapid detection of streptococcus pneumoniae employing purified antigen-specific antibodies.
Geiger Thomas (Diessen DEX) Engel Wolf D. (Feldafing DEX) Schmitt Urban (Oberhausen DEX) Maurer Eberhard (Weilheim DEX) Rdinger Wolfgang (Birkenau DEX) Deeg Rolf (Bernried DEX), Process and reagent for the determination of an antibody.
McFarland Edward (Baltimore MD) Uithoven Keith (West Friendship MD) Carlson Jeffrey (Mountain View CA), Process, test device, and test kit for a rapid assay having a visible readout.
Litman David J. (Los Altos CA) Li Thomas M. (Milpitas CA) Buelteman Laura L. (San Jose CA) Wong Emmy T. (Los Altos Hills CA), Qualitative immunochromatographic method and device.
Litman David J. (Los Altos CA) Li Thomas M. (Milpitas CA) Buelteman Laura L. (San Jose CA) Wong Emmy T. (Los Altos Hills CA), Qualitative immunochromatographic method and device.
Vallari Anadruzela S. ; Hackett ; Jr. John R. ; Hickman Robert K. ; Varitek ; Jr. Vincent A. ; Necklaws Elizabeth C. ; Golden Alan M. ; Brennan Catherine A. ; Devare Sushil G., Rapid assay for simultaneous detection and differentiation of antibodies to HIV groups.
Stewart Sandy J. (Durham NC), Rapid immunoassay for detection of antibodies or antigens incorporating simultaneous sample extraction and immunogenic r.
Kortright Kenneth H. (Cooper City FL) Hofheinz David E. (Homestead FL) Allman David M. (Miami FL) Forman Meryl A. (Miami FL) Lee Song Y. (Plantation FL) Smariga Paulette E. (North Miami FL) Stoner Ca, Simultaneous enzyme immunoassay for detecting antigen and/or antibody in humans.
Merkh Carl W. (Lindenhurst IL) Defreese James D. (Wildwood IL) Durley ; III ; deceased Benton A. (late of Antioch IL by Robert W. Durley ; executrix), Test array for performing assays.
Berger Dieter (Viernheim DEX) Knappe Wolfgang-Reinhold (Brstadt DEX) Lorenz Robert (Ludwigshafen IN DEX) Grage ; Jr. Henry M. (Carmel IN) Skarstedt Mark T. (Indianapolis IN) Sojka Bernward (Viernheim, Test carrier and method for the analytical determination of components of body fluids.
Eikmeier Henio (Lorsch IN DEX) Freitag Helmut (Indianapolis IN) Mnter Karin (Mannheim IN DEX) Pollmann Klaus (Indianapolis IN) Wilk Hans-Erich (Lorsch DEX) Winkle Johannes (Hirschberg-Leutershausen D, Test carrier for analysis of a liquid sample.
Freitag Helmut (Indianapolis IN) Wilk Hans-Erich (Lorsch DEX) Rothe Anselm (Birkenau DEX) Eikmeier Heino (Lorsch DEX), Test carrier for the analysis of a sample liquid.
Freitag Helmut (Indianapolis IN) Rothe Anselm (Birkenau IN DEX) Pollmann Klaus (Indianapolis IN), Test carrier for the analytical determination of a component of a liquid sample.
Schlipfenbacher Reiner (Lampertheim DEX) Steinbiss Joachim (Lorsch DEX), Test carrier for the analytical determination of a component of a liquid sample.
Schlipfenbacher Reiner (Lampertheim DEX) Steinbiss Joachim (Lorsch DEX) Trasch Heinz-Friedrich (Ludwigshafen DEX), Test carrier for the analytical determination of a component of a liquid sample.
May Keith (Bedfordshire GB2) Prior Michael Evans (Northamptonshire GB2) Richards Ian (Bedford GB2), Test device for detecting analytes in biological samples.
Kouvonen Ilkka Sakari,FIX ; Svens Eivor Helena,FIX ; Tikanoja Sari Hannele,FIX ; Turunen Pekka Antero,FIX ; Sivonen Lauri Markus,FIX, Test strip, its production and use.
Albarella James P. ; Hildenbrand Karl-Heinz,DEX ; Lin Spencer H. ; Pugia Michael J. ; Schulman LLoyd S., Transparent flow through membrane for dry reagent analytical devices.
Andreyev, Boris; Chu, Steven; Ciopyk, Brian; De La Zerda, Adam; Huang, Helen; Loney, Gregory; Swenson, David D., Devices and methods for molecular diagnostic testing.
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