Electrode structures and methods for their use in cardiovascular reflex control
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/00
A61N-001/36
A61B-005/02
A61N-001/05
A61N-001/08
A61N-001/37
출원번호
US-0690016
(2012-11-30)
등록번호
US-8880190
(2014-11-04)
발명자
/ 주소
Kieval, Robert S
Keith, Peter T
Burns, Matthew
Hektner, Thomas
출원인 / 주소
CVRx, Inc.
대리인 / 주소
Patterson Thuente Pedersen P.A.
인용정보
피인용 횟수 :
5인용 특허 :
279
초록▼
Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located i
Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
대표청구항▼
1. A baroreflex modification system comprising: a baroreceptor activation device arranged to be coupled to a vascular wall, the vascular wall containing at least one baroreceptor; anda control system comprising a driver coupled to the baroreceptor activation device, the driver being configured to dr
1. A baroreflex modification system comprising: a baroreceptor activation device arranged to be coupled to a vascular wall, the vascular wall containing at least one baroreceptor; anda control system comprising a driver coupled to the baroreceptor activation device, the driver being configured to drive mechanical motion of at least a portion of the activation device, wherein the mechanical motion causes indirect activation of the baroreceptor by stretching or deforming the vascular wall surrounding the baroreceptor. 2. The system of claim 1, wherein the control system includes a processor and a programmable memory, the control system programmed to generate a control signal and deliver the control signal to the driver. 3. The system of claim 2, comprising a user interface coupled to the control system, the user interface being arranged to receive a value or a command in relation to the generated control signal, wherein the memory is configured to store data related to the generated control signal and/or the value or command received by the user interface. 4. The system of claim 2, wherein the memory stores a stimulus regimen, wherein the control system is arranged to generate the control signal in accordance with the stimulus regimen. 5. The system of claim 4, wherein the stimulus regimen is chosen to promote long term efficacy of baroreceptor activation. 6. The system of claim 4, wherein the stimulus regimen comprises a first level to establish a desired therapeutic effect and a second level to sustain the desired effect. 7. The system of claim 2, wherein the control signal comprises a continuous, periodic or episodic signal, or a combination thereof. 8. The system of claim 7, wherein an episodic control signal can be triggered by an episode wherein the episode comprises a sensed increase of a physiological parameter above a certain threshold and/or a sensed decrease below of a physiological parameter below a certain threshold. 9. The system of claim 1, wherein the activation device is arranged for pneumatic or hydraulic actuation in response to the control signal so as to compress and/or expand the tissue. 10. The system of claim 1, comprising a sensor coupled to the control system, wherein the sensor is configured to monitor a parameter indicative of a need to modify the baroreflex system and to provide to the control system a sensor signal indicative of the sensed parameter. 11. The system of claim 10, wherein the control system contains software containing an algorithm defining one or more functions or relationships between the control signal and the sensor signal, wherein the algorithm prescribes starting or stopping provision of the control signal to the driver based on the sensor signal. 12. The system of claim 11, wherein the algorithm dictates one or more of the following starting or stopping provision of the control signal when the sensor signal falls below a predetermined threshold value or rises above a predetermined threshold value or when the sensor signal indicates a specific physiological event. 13. The system of claim 1, wherein the baroreceptor activation device comprises an intravascular device. 14. The system of claim 13, wherein the activation device comprises an intravascular inflatable balloon having a geometry which allows blood perfusion therethrough. 15. The system of claim 14, wherein the driver comprises an inflation device in fluid communication with a fluid reservoir, the driver being coupled to the activation device by at least one fluid line. 16. The system of claim 15, wherein the inflation device comprises a pressure or a vacuum source. 17. The system of claim 14, wherein the intravascular inflatable balloon includes a helical geometry. 18. The system of claim 13, wherein the activation device comprises an intravascular mechanical expansion device having tubular braid configured to diametrically expand when longitudinally compressed. 19. The system of claim 13, wherein the activation device comprises an intravascular flow regulator arranged to artificially create back pressure adjacent the baroreceptor, the intravascular flow regulator comprising a valve configured to at least partially close the vascular lumen. 20. The system of claim 1, wherein the baroreceptor activation device comprises an extravascular device. 21. The system of claim 20, wherein the activation device comprises an extravascular inflatable pressure cuff. 22. The system of claim 21, wherein the driver comprises an inflation device in fluid communication with a fluid reservoir, the driver being coupled to the activation device by at least one fluid line, optionally wherein the inflation device comprises a pressure or a vacuum source. 23. The system of claim 22, wherein the inflation device comprises a pressure or a vacuum source. 24. The system of claim 20, wherein the activation device comprises an extravascular mechanical compression device, wherein the compression device comprises a piston device, the piston device being actuated by solenoid, hydraulic or pneumatic means. 25. The system of claim 24, wherein the activation device comprises an extravascular mechanical compression device, wherein the compression device comprises a rotary ring compression device. 26. The system of claim 20, wherein the activation device comprises an extravascular flow regulator arranged to artificially create back pressure adjacent the baroreceptor, the extravascular flow regulator comprising an external compression device. 27. The system of claim 1, wherein the activation device comprises a transducer, wherein the driver is an electric power generator or amplifier and is coupled to the activation device by at least one electrical lead, wherein the transducer comprises an acoustic transmitter arranged to transmit sonic or ultrasonic waves into vascular wall to cause vibration of the vascular wall. 28. The system of claim 1, wherein the activation device is configured to be implanted at a location within a patient proximate one or more baroreceptors, the location selected from the group consisting of: a carotid sinus, an aortic arch, a common carotid artery, a subclavian artery, a brachiocephalic artery, and a heart. 29. An implantable baroreflex modification system, comprising: a baroreceptor activation device arranged to be coupled to a vascular wall, the vascular wall containing at least one baroreceptor, wherein the activation device includes a means for mechanically activating the baroreceptor; anda control system coupled to the baroreceptor activation device, the control system programmed to deliver a control signal to the baroreceptor activation device to cause the means for mechanically activating to stretch or deform the vascular wall surrounding the baroreceptor. 30. A method, comprising: causing a baroreceptor activation device to be manufactured and made available to a user;causing a control system to be manufactured and made available to the user, the control system comprising a driver coupled to the baroreceptor activation device; andproviding instructions to the user, comprising: implanting the baroreceptor activation device in contact with a vascular wall, the vascular wall containing at least one baroreceptor; andcausing the driver to drive mechanical motion of at least a portion of the activation device, wherein the mechanical motion causes indirect activation of the baroreceptor by stretching or deforming the vascular wall surrounding the baroreceptor.
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이 특허에 인용된 특허 (279)
Funke Hermann D. (Bonn DEX), Acoustic body bus medical device communication system.
Berne Robert M. (Charlottesville VA) Belardinelli Luiz (Charlottesville VA) Rubio Rafael (Charlottesville VA), Adenosine antagonists in the treatment and diagnosis of A-V node conduction disturbances.
Boveja Birinder Bob, Apparatus and method for adjunct (add-on) therapy of partial complex epilepsy, generalized epilepsy and involuntary movement disorders utilizing an external stimulator.
Boveja, Birinder R., Apparatus and method for adjunct (add-on) treatment of coma and traumatic brain injury with neuromodulation using an external stimulator.
Schroeppel Edward A. (Miramar FL), Apparatus and method for adjusting heart/pacer relative to changes in venous diameter during exercise to obtain a requir.
Boveja, Birinder R., Apparatus and method for electrical stimulation adjunct (add-on) therapy of atrial fibrillation, inappropriate sinus tachycardia, and refractory hypertension with an external stimulator.
Spreigl William T. ; Hess Douglas N ; Heynen Henri G.,NLX ; Struble Chester I.,NLX ; von Venrooij Paulus C.,NLX, Apparatus and method for fixing electrodes in a blood vessel.
King Gary W., Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control.
Ding, Jiang; Kramer, Andrew P.; Spinelli, Julio C., Apparatus and method for ventricular pacing triggered by detection of early ventricular excitation.
Arai Makoto R. (Chicago IL) Gordon David (Chicago IL) McAlpine Laura E. (Chicago IL), Apparatus for monitoring cardiovascular regulation using heart rate power spectral analysis.
Kapp John P. (455 Bunkers Cove Rd. Panama City FL 32401) Robertson James T. (628 W. Trezevant Memphis TN 38112) Tucker Elton M. (8 Oxbow Rd. Medfield MA 02052), Arterial pressure control system.
Adkins Robert A. ; O'Donovan Cormac A. ; Terry ; Jr. Reese S., Automatic activation of a neurostimulator device using a detection algorithm based on cardiac activity.
Bozeman ; Jr. Richard J. (Dickinson TX) Akkerman James W. (Houston TX) Aber Gregory S. (Houston TX) Damm George Arthur Van (Houston TX) Bacak James W. (Houston TX) Svejkovsky Paul A. (Webster TX) Ben, Axial pump.
Stadler Robert W. ; Nelson Shannon, Axis shift analysis of electrocardiogram signal parameters especially applicable for multivector analysis by implantable medical devices, and use of same.
Kieval Robert S. ; Bettett Tom D. ; Fitts Stephanie Michele, Baroreflex modulation with carotid sinus nerve stimulation for the treatment of heart failure.
Dahl Roger W. (Andover MN) Swanson David K. (Roseville MN) Hahn Stephen J. (Roseville MN) Lang Douglas J. (Arden Hills MN) Heil John E. (St. Paul MN), Body implantable defibrillation system.
Heil ; Jr. Ronald W. (Roseville MN) Owens Robert C. (Forest Lake MN) Pederson Brian D. (St. Paul MN), Cardiac electrode with drug delivery capabilities.
Ding, Jiang; Spinelli, Julio C.; Kramer, Andrew P., Cardiac rhythm management system selecting between multiple same-chamber electrodes for delivering cardiac therapy.
Baumann, Lawrence S.; Kadhiresan, Veerichetty A., Cardiac rhythm management system with respiration synchronous optimization of cardiac performance using atrial cycle length.
Fogarty Thomas J. (770 Welch Rd. Palo Alto CA 94304) Kinney Thomas B. (San Diego CA) Finn ; III James C. (Menlo Park CA), Catheter with corkscrew-like balloon.
Wolff Rodney G. (468 W. Eagle Lake Dr. Maple Grove MN 55369) Dance Creg W. (812 Benton St. Anoka MN 55303) Letac Brice (134 rue du Renard 76.000 Roven FRX) Cribier Alain (76150 Maromme Maromme FRX), Compressive stent and delivery system.
Claracq Michel (17 ; rue de Vittel 31300 Toulouse FRX), Device for partly occluding a vessel in particular the inferior vena cava and inherent component of this device.
Zacouto Fred (16 rue de la Convention 75 015 Paris FRX), Device for protection against blood-related disorders, notably thromboses, embolisms, vascular spasms, hemorrhages, hemo.
Kieval, Robert S.; Persson, Bruce J.; Serdar, David J.; Keith, Peter T.; Rossing, Martin A., Devices and methods for cardiovascular reflex control via coupled electrodes.
Kieval, Robert S.; Persson, Bruce J.; Serdar, David J.; Keith, Peter T.; Rossing, Martin A., Devices and methods for cardiovascular reflex control via coupled electrodes.
Kieval,Robert S.; Persson,Bruce J.; Serdar,David J.; Keith,Peter T.; Irwin,Eric D., Electrode designs and methods of use for cardiovascular reflex control devices.
Bolea,Stephen L.; Kieval,Robert S.; Persson,Bruce J.; Serdar,David J.; Keith,Peter T.; Irwin,Eric D.; Rossing,Martin A., Electrode structures and methods for their use in cardiovascular reflex control.
Fenner Andreas A. ; Larson Lary R. ; Greeninger Daniel R. ; Thompson David L., Feedthrough assembly for implantable medical devices and methods for providing same.
Nappholz Tibor A. (Englewood CO) Hursta William N. (Littleton CO) Dawson Albert K. (Denver CO) Steinhaus Bruce M. (Parker CO), Implantable ambulatory electrocardiogram monitor.
Halperin Louis E. (St. Paul MN) Lee Brian B. (Golden Valley MN) Roline Glenn M. (Anoka MN) Varrichio Anthony J. (Flanders NJ), Implantable capacitive absolute pressure and temperature monitor system.
Kroll Mark W. (Minnetonka MN) Nelson Randall S. (Pine Springs MN) Adams Theodore P. (Edina MN), Implantable cardioverter defibrillator pulse generator kite-tail electrode system.
Hassler Beth Anne ; Donders Adriannus P. ; Wiklund Craig L. ; Lyons Daniel A., Implantable ceramic enclosure for pacing, neurological, and other medical applications in the human body.
Obel Israel W. P. (Johannesburg ZAX) Bourgeois Ivan (Verviers BEX), Implantable electrical nerve stimulator/pacemaker with ischemia for decreasing cardiac workload.
Schulman Joseph H. (Santa Clarita CA) Strojnik Primoz (Granada Hills CA) Meadows Paul (Altadena CA), Implantable microdevice with self-attaching electrodes.
Scheiner, Avram; Heil, Jr., Ronald W.; Kelley, Peter T.; Tockman, Bruce; Westlund, Randy; Warren, Jay A., Leads for pacing and/or sensing the heart from within the coronary veins.
Di Domenico Edward D. (Anoka MN) Hobot Christopher M. (Tonka Bay MN) Stokes Kenneth B. (Minneapolis MN) Coury Arthur J. (St. Paul MN) Doan Phong D. (Shoreview MN) Sandstrom Richard D. (Scandia MN), Medical electrical lead with polymeric monolithic controlled release device and method of manufacture.
Stroetmann Brigitte (Uttenreuth DEX) Holmstrom Nils (Jarfalla SEX) Kallert Siegfried (Erlangen DEX) Bowald Staffan (Almunge SEX), Method and apparatus for cardiac therapy by stimulation of a physiological representative of the parasympathetic nervous.
Stadler Robert ; Nelson Shannon ; Stylos Lee ; Sheldon Todd J., Method and apparatus for filtering electrocardiogram (ECG) signals to remove bad cycle information and for use of physiologic signals determined from said filtered ECG signals.
Cohen Richard J. (Waban MA) Appel Marvin L. (Cambridge MA) Berger Ronald D. (Brookline MA), Method and apparatus for physiologic system identification.
Verrier Richard L. (Bethesda MD) Nearing Bruce D. (Bethesda MD), Method and apparatus for prediction of sudden cardiac death by simultaneous assessment of autonomic function and cardiac.
Edell David J. (Lexington MA) Wyatt ; Jr. John L. (Sudbury MA) Rizzo ; III Joseph (Boston MA), Method and apparatus for preferential neuron stimulation.
Webster ; Jr. Wilton W. ; Scherlag Benjamin J. ; Scherlag Michael ; Schauerte Patrick, Method and apparatus for transvascular treatment of tachycardia and fibrillation.
Geddes Leslie A. (West Lafayette IN) Elabbady Tarek (Kirkland WA) Schoenlein William E. (Lafayette IN) Waninger Matthew (Frankfort IN) Bourland Joe D. (West Lafayette IN), Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation.
Geddes Leslie A. ; Elabbady Tarek ; Schoenlein William E. ; Waninger Matthew ; Bourland Joe D., Method and apparatus using vagal stimulation for control of ventricular rate during atrial fibrillation.
Hill Michael R. S. ; Jonkman Kenneth R., Method and device for electronically controlling the beating of a heart using venous electrical stimulation of nerve fibers.
Corbucci Giorgio (San Giovanni In Persiceto ITX), Method and device for monitoring and detecting sympatho-vagal activity and for providing therapy in response thereto.
Brabec Scott J. ; Brennen Kenneth R. ; Schindeldecker William J. ; Spear Stanten C. ; Rugland Roger E. ; Johnson Bruce C., Method for tissue stimulation and fabrication of low polarization implantable stimulation electrode.
Gordon David (Chicago IL) Akselrod Solange (Ramat-Ilan MA ILX) Cohen Richard J. (Newton Highlands MA) Tu Jerome C. (Monterey Park CA) Burns Stephen K. (Henniker NH) DeLeon Victoria H. (Arlington MA), Methods and apparatus for monitoring cardiovascular regulation using heart rate power spectral analysis.
Larsen Charles E. (Cumming GA) Trip Roel (Snellville GA) Johnson Cheryl R. (Atlanta GA), Methods for procedures related to the electrophysiology of the heart.
Naritoku Dean K. ; Jensen Robert A. ; Browning Ronald A. ; Clark Kevin B. ; Smith Douglas C. ; Terry ; Jr. Reese S., Methods of treating traumatic brain injury by vagus nerve stimulation.
Russell,Ted W., Methods, apparatus and articles-of-manufacture for noninvasive measurement and monitoring of peripheral blood flow, perfusion, cardiac output biophysic stress and cardiovascular condition.
Klein George J.,CAX ; Warkentin Dwight H. ; Riff Kenneth M. ; Lee Brian B. ; Carney James K. ; Turi Gregg ; Varrichio Anthony J., Minimally invasive implantable device for monitoring physiologic events.
Kroll Mark W. (Minnetonka MN) Adams Theodore P. (Edina MN) Perttu Joseph S. (Chanhassen MN) Supino Charles (Arden Hills MN), Multiplexed defibrillation electrode apparatus.
Keller ; Jr. John W. (Miami FL) Bursack William E. (New Brighton MN) Coombes Alan (Brooklyn Park MN), Mutually noninterfering transcutaneous nerve stimulation and patient monitoring.
Grandjean Pierre A. (Rue Du Mari 7 Bassenge MN BEX) Lee Philip H. J. (6461 Crackleberry Trail Woodbury MN 55125), Nerve electrode with biological substrate.
Bennett Tommy D. (Shoreview MN) Nichols Lucy M. (Maple Grove MN) Roline Glenn M. (Anoka MN) Thompson David L. (Fridley MN), Rate responsive pacemaker and pacing method.
Doten, Gregory P.; Brockway, Brian P.; Brockway, Robert V.; Fundakowski, Richard A., Respiration monitoring system based on sensed physiological parameters.
Kramer,Andrew P.; Kadhiresan,Veerichetty; Ding,Jiang; Baumann,Lawrence; Vanderlinde,Scott, Resynchronization method and apparatus based on intrinsic atrial rate.
Leonardo Cammilli IT; Gino Grassi IT, SINGLE PASS MULTIPLE CHAMBER IMPLANTABLE ELECTRO-CATHETER FOR MULTI-SITE ELECTRICAL THERAPY OF UP TO FOUR CARDIAC CHAMBERS, INDICATED IN THE TREATMENT OF SUCH PATHOLOGIES AS ATRIAL FIBRILLATION AND C.
Dahl Roger W. (Andover MN) Wickham ; deceased Robert W. (late of Harris MN by Duane Quiggle ; administrator) Swanson David K. (Roseville MN) Lipson David (Poway CA), Stent-type defibrillation electrode structures.
Lee Philip (Woodbury MN) Stokes Kenneth (Brooklyn Park MN) Gates James (Maple Grove MN) Johnson Gary (Ramsey MN), Steroid eluting cuff electrode for peripheral nerve stimulation.
Lee Philip (Woodbury MN) Stokes Kenneth (Brooklyn Park MN) Colson Michael (Minneapolis MN), Steroid eluting electrode for peripheral nerve stimulation.
Bennett Tom D. (Shoreview MN) Combs William J. (Eden Prairie MN) Kallok ; Michael J. (New Brighton MN) Lee Brian B. (Golden Valley MN) Mehra Rahul (Stillwater MN) Klein George J. (London CAX), Subcutaneous multi-electrode sensing system, method and pacer.
Tanagho Emil A. (San Rafael CA) Schmidt Richard A. (San Rafael CA) Gleason Curtis A. (Palo Alto CA) Lue Tom F. (Millbrae CA), Surgically implantable peripheral nerve electrode.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Zabara Jacob (Philadelphia PA), Treatment of neuropsychiatric disorders by nerve stimulation.
Wernicke Joachim F. (League City TX) Terry ; Jr. Reese S. (Houston TX) Baker ; Jr. Ross G. (Houston TX), Treatment of patients in coma by nerve stimulation.
Bolea, Stephen L.; Kieval, Robert S.; Persson, Bruce J.; Serdar, David J.; Keith, Peter T.; Irwin, Eric D.; Rossing, Martin A., Electrode structures and methods for their use in cardiovascular reflex control.
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