Multi-formed collagenous biomaterial medical device
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-002/02
A61K-038/17
A61K-035/22
A61K-035/38
A61L-027/36
A61L-029/00
A61L-031/00
출원번호
US-0931638
(2007-10-31)
등록번호
US-8882850
(2014-11-11)
발명자
/ 주소
Hiles, Michael C.
Patel, Umesh H.
출원인 / 주소
Cook Biotech Incorporated
대리인 / 주소
Woodard, Emhardt, Moriarty, McNett & Henry LLP
인용정보
피인용 횟수 :
4인용 특허 :
112
초록▼
A collagenous biomaterial medical device comprising a molded sponge material formed from comminuted submucosa fragments that have not been cross-linked with a cross-linking agent, wherein said submucosa has at least one biotropic agent, and wherein said biotropic agent is a growth factor is disclose
A collagenous biomaterial medical device comprising a molded sponge material formed from comminuted submucosa fragments that have not been cross-linked with a cross-linking agent, wherein said submucosa has at least one biotropic agent, and wherein said biotropic agent is a growth factor is disclosed.
대표청구항▼
1. A collagenous biomaterial comprising a molded sponge material formed from comminuted submucosa fragments that have not been cross-linked with a cross-linking agent, wherein said submucosa has at least one biotropic agent, wherein said biotropic agent is a growth factor. 2. The collagenous biomate
1. A collagenous biomaterial comprising a molded sponge material formed from comminuted submucosa fragments that have not been cross-linked with a cross-linking agent, wherein said submucosa has at least one biotropic agent, wherein said biotropic agent is a growth factor. 2. The collagenous biomaterial of claim 1 formed by a process including freezing and drying a material including comminuted submucosa fragments and water. 3. The collagenous biomaterial of claim 1 also comprising at least one pharmacologic agent disposed on the sponge material. 4. The collagenous biomaterial of claim 1 wherein the at least one biotropic agent further includes a proteoglycan and a glycosaminoglycan. 5. The collagenous biomaterial of claim 3 wherein the pharmacologic agent includes one or more growth factors, proteins, proteoglycans, glycosaminoglycans, physiological compatible minerals, antibiotics, chemotherapeutic agents, enzymes, drugs, or hormones. 6. The collagenous biomaterial of claim 1, wherein said submucosa is intestinal submucosa, urinary bladder submucosa, or stomach submucosa. 7. The collagenous biomaterial of claim 6, wherein said submucosa is small intestinal submucosa. 8. The collagenous biomaterial of claim 7, wherein said small intestinal submucosa is porcine. 9. The collagenous biomaterial of claim 1, wherein the sponge material is configured as a plug for stopping bleeding. 10. The collagenous biomaterial of claim 1, wherein the sponge material is in injectable form. 11. The collagenous biomaterial of claim 1, wherein the submucosa comprises attached lamina muscularis mucosa and stratum compactum tissue. 12. A collagenous biomaterial comprising a sponge material formed from comminuted submucosa tissue fragments that have not been cross-linked with a cross-linking agent, wherein said submucosa has at least one biotropic agent, wherein said biotropic agent is a growth factor. 13. The collagenous biomaterial of claim 12, wherein said submucosa is intestinal submucosa, urinary bladder submucosa, or stomach submucosa. 14. The collagenous biomaterial of claim 13, wherein said submucosa is small intestinal submucosa. 15. The collagenous biomaterial of claim 14, wherein said small intestinal submucosa is porcine. 16. The collagenous biomaterial of claim 12, wherein the submucosa comprises attached lamina muscularis mucosa and stratum compactum tissue. 17. The collagenous biomaterial of claim 1, wherein the submucosa has a preserved inherent biochemistry. 18. The collagenous biomaterial of claim 12, wherein the submucosa has a preserved inherent biochemistry.
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