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System, devices and methods are presented that integrate stretchable or flexible circuitry, including arrays of active devices for enhanced sensing, diagnostic, and therapeutic capabilities. The invention enables conformal sensing contact with tissues of interest, such as the inner wall of a lumen,

System, devices and methods are presented that integrate stretchable or flexible circuitry, including arrays of active devices for enhanced sensing, diagnostic, and therapeutic capabilities. The invention enables conformal sensing contact with tissues of interest, such as the inner wall of a lumen, a nerve bundle, or the surface of the heart. Such direct, conformal contact increases accuracy of measurement and delivery of therapy.

대표청구항 ▼

1. An apparatus comprising: a stretchable substrate;a stretchable circuitry selectively attached to said stretchable substrate, said stretchable circuitry comprising:an array of recording electrodes receiving signals from a plurality of nerve sources when at least a portion of said array of recordin

1. An apparatus comprising: a stretchable substrate;a stretchable circuitry selectively attached to said stretchable substrate, said stretchable circuitry comprising:an array of recording electrodes receiving signals from a plurality of nerve sources when at least a portion of said array of recording electrodes is in electrical contact with said plurality of nerve sources;a plurality of amplifiers, each amplifier of said plurality of amplifiers being in electronic communication with a recording electrode of said array of recording electrodes;at least one stretchable interconnect capable of being made longer or wider without tearing or breaking, said at least one stretchable interconnect disposed between, and in electrical communication with, at least one recording electrode of the array of recording electrodes and at least one amplifier of the plurality of amplifiers, said at least one recording electrode of the array of recording electrodes and said at least one amplifier of the plurality of amplifiers being selectively attached to said stretchable substrate, and at least a portion of said at least one stretchable interconnect being free of said stretchable substrate; andan array of stimulating electrodes; anda processing facility in electronic communication with said array of recording electrodes and said array of stimulating electrodes that receives said signals from a plurality of nerve sources from said recording electrodes and is configured to determine a pattern of stimulation signals to be effected by said array of stimulating electrodes. 2. The apparatus of claim 1, wherein said electrical contact comprises physical contact. 3. The apparatus of claim 1, further comprising a multiplexer configured to match said signals from said nerve sources and cause at least one of said plurality of stimulating electrodes to dispatch a corresponding signal to a second plurality of nerves. 4. The apparatus of claim 1, further comprising a user interface to allow an operator to adjust said pattern of stimulation signals. 5. The apparatus of claim 1, wherein said stretchable substrate is an inflatable body. 6. The apparatus of claim 5, wherein said inflatable body is a disk. 7. The apparatus of claim 1, wherein said pattern of stimulation signals is dynamically configurable. 8. The apparatus of claim 1, wherein said processing facility is further configured to generate data related to the electrical conductivity of said nerve sources. 9. The apparatus of claim 8, wherein said processing facility is in electronic communication with an output facility and causes said output facility to generate a map, said map being based on said data related to the electrical conductivity of said nerve sources. 10. The apparatus of claim 1, wherein said stretchable circuitry is encapsulated with a thin polymer layer. 11. The apparatus of claim 1, wherein said stretchable circuitry comprises at least one stretchable electrical interconnect, and wherein said stretchable circuitry is stretchable up to 300%. 12. The apparatus of claim 1, wherein said electrodes are located discretely from one another. 13. The apparatus of claim 1, wherein said at least one stretchable interconnect of said stretchable circuitry is a plurality of stretchable electrical interconnects. 14. The apparatus of claim 13, wherein said plurality of stretchable electrical interconnects electrically connect said array of recording electrodes and said plurality of stimulating electrodes. 15. The apparatus of claim 1, wherein said stretchable circuitry comprises temperature sensors. 16. The apparatus of claim 1, wherein said stretchable circuitry comprises contact sensors. 17. The apparatus of claim 1, wherein said stretchable circuitry comprises pressure sensors. 18. The apparatus of claim 1, wherein said stretchable substrate comprises a reservoir in communication with a surface of said stretchable substrate. 19. The apparatus of claim 18, wherein said stretchable circuitry is configured to open valves operable to release a drug contained within said reservoir. 20. The apparatus of claim 19, wherein said stretchable circuitry causes the valves to release said drug in a controlled manner. 21. The apparatus of claim 1, further comprising at least one stretchable interconnect disposed between, and in electrical communication with, at least one stimulating electrode of the array of stimulating electrodes and at least one amplifier of the plurality of amplifiers. 22. An apparatus comprising: a stretchable substrate;a stretchable circuitry selectively attached to said stretchable substrate, said stretchable circuitry comprising:a plurality of dynamically configurable electrodes, wherein a first set of the plurality of dynamically configurable electrodes is configured as recording electrodes to provide an array of recording electrodes, said recording electrodes receiving signals from a plurality of nerve sources when said array of recording electrodes is in electrical contact with said plurality of nerve sources;wherein a second set of the plurality of dynamically configurable electrodes is configured as stimulating electrodes to provide an array of stimulating electrodes; andwherein a dynamically configurable electrode of said plurality of dynamically configurable electrodes can be configured at different times as a recording electrode or as a stimulating electrode;a plurality of amplifiers, each amplifier of said plurality of amplifiers being in electronic communication with a recording electrode or a sensing electrode; andat least one stretchable interconnect capable of being made longer or wider without tearing or breaking, said at least one stretchable interconnect disposed between, and in electrical communication with, at least one dynamically configurable electrode of the plurality of dynamically configurable electrodes and at least one amplifier of the plurality of amplifiers, said at least one dynamically configurable electrode of the plurality of dynamically configurable electrodes and said at least one amplifier of the plurality of amplifiers being selectively attached to said stretchable substrate, and at least a portion of said at least one stretchable interconnect being free of said stretchable substrate; anda processing facility in electronic communication with said plurality of dynamically configurable electrodes that receives said signals from a plurality of nerve sources from said recording electrodes and is configured to determine a pattern of stimulation signals to be effected by said stimulating electrodes. 23. The apparatus of claim 22, wherein said plurality of amplifiers comprises sensing amplifiers and stimulation amplifiers, wherein a dynamically configurable electrode that is configured as a recording electrode is placed in electronic communication with a sensing amplifier of said plurality of amplifiers, and wherein a dynamically configurable electrode that is configured as a stimulating electrode is placed in electronic communication with a stimulation amplifier of said plurality of amplifiers. 24. An apparatus comprising: a stretchable substrate, said stretchable substrate having a first layer and a second layer, said first layer and said second layer separated by a height;a stretchable circuitry disposed on said stretchable substrate, said stretchable circuitry comprising:an array of recording electrodes receiving signals from a plurality of nerve sources when at least a portion of said array of recording electrodes is in electrical contact with said plurality of nerve sources;a plurality of amplifiers, each amplifier of said plurality of amplifiers being in electronic communication with a recording electrode of said array of recording electrodes;at least one stretchable interconnect capable of being made longer or wider without tearing or breaking, said at least one stretchable interconnect disposed between, and in electrical communication with, at least one recording electrode of the array of recording electrodes and at least one amplifier of the plurality of amplifiers, said at least one recording electrode of said array of recording electrodes and said at least one amplifier of said plurality of amplifiers being coupled to said first layer, and said at least one stretchable interconnect free to be displaced perpendicular to said second layer; andan array of stimulating electrodes; anda processing facility in electronic communication with said array of recording electrodes and said array of stimulating electrodes that receives said signals from a plurality of nerve sources from said recording electrodes and is configured to determine a pattern of stimulation signals to be effected by said array of stimulating electrodes.