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Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-001/20
  • C12P-007/18
  • C12P-007/42
  • C12N-009/04
  • C12N-009/88
  • C12N-009/00
  • C12N-009/02
  • C12P-007/52
  • C12P-017/04
출원번호 US-0286135 (2011-10-31)
등록번호 US-8889399 (2014-11-18)
발명자 / 주소
  • Burk, Mark J.
  • Van Dien, Stephen J.
  • Burgard, Anthony P.
  • Niu, Wei
출원인 / 주소
  • Genomatica, Inc.
대리인 / 주소
    Jones Day
인용정보 피인용 횟수 : 0  인용 특허 : 95

초록

The invention provides a non-naturally occurring microbial organism having 4-hydroxybutanoic acid (4-HB) and 1,4-butanediol (1,4-BDO) biosynthetic pathways. The pathways include exogenous nucleic acids encoding a) an α-ketoglutarate decarboxylase; b) a 4-hydroxybutanoate dehydrogenase; c) a 4-hydrox

대표청구항

1. A non-naturally occurring microbial organism having increased production of 1,4-butanediol, which is prepared by introducing exogenous genes or increasing expression of endogenous genes encoding enzymes converting succinate into 4-hydroxybutyrate, 4-hydroxybutyrate into 4-hydroxybutyryl-CoA direc

이 특허에 인용된 특허 (95)

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