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RNA interference mediating small RNA molecules

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07H-021/04
  • C07H-021/02
  • A61K-048/00
출원번호 US-0725262 (2012-12-21)
등록번호 US-8895721 (2014-11-25)
우선권정보 EP-00126325 (2000-12-01)
발명자 / 주소
  • Tuschl, Thomas
  • Elbashir, Sayda Mahgoub
  • Lendeckel, Winfried
출원인 / 주소
  • Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V.
대리인 / 주소
    Lando & Anastasi, LLP
인용정보 피인용 횟수 : 3  인용 특허 : 44

초록

Double-stranded RNA (dsRNA) induces sequence-specific post-transcriptional gene silencing in many organisms by a process known as RNA interference (RNAi). Using a Drosophila in vitro system, we demonstrate that 19-23 nt short RNA fragments are the sequence-specific mediators of RNAi. The short inter

대표청구항

1. An isolated double-stranded RNA molecule, comprising: (i) a sense strand and an antisense strand that form a double-stranded region consisting of 14-24 base pairs;(ii) at least one strand having a single-stranded 3′-overhang; and(iii) at least one nucleotide analogue, wherein said RNA molecule is

이 특허에 인용된 특허 (44)

  1. Chris A. Buhr ; Mark Matteucci, 2' Modified oligonucleotides.
  2. Wands Jack R. ; Wakita Takaja ; Moradpour Darius, Antisense inhibition of hepatitis C virus.
  3. Crooke Stanley T. (Carlsbad CA) Mirabelli Christopher K. (Encinitas CA) Ecker David J. (Carlsbad CA) Cowsert Lex M. (Carlsbad CA), Antisense oligonucleotide inhibition of papillomavirus.
  4. Monia Brett P. (Carlsbad CA) Freier Susan M. (San Diego CA) Ecker David J. (Leucadia CA), Antisense oligonucleotide inhibition of the RAS gene.
  5. Baracchini Edgardo ; Bennett C. Frank ; Dean Nicholas M., Antisense oligonucleotide modulation of multidrug resistance-associated protein.
  6. Szyf Moshe,CAX ; Hofe Eric von, Antisense oligonucleotides having tumorigenicity-inhibiting activity.
  7. Friesen Albert D. (Winnipeg CAX), Antisense oligonucleotides targeted against human immunodeficiency virus.
  8. Cook Phillip Dan ; Manoharan Muthiah ; Bruice Thomas, Covalently cross-linked oligonucleotides.
  9. Szyf Moshe (Cote St. Luc CAX) von Hofe Eric (Wellesley MA), DNA methyltransferase antisense oligonucleotides.
  10. Dietz Harry C., Delivery construct for antisense nucleic acids and methods of use.
  11. Felgner Philip L. (Rancho Santa Fe CA) Wolff Jon A. (Madison WI) Rhodes Gary H. (Leucadia CA) Malone Robert W. (Chicago IL) Carson Dennis A. (Del Mar CA), Delivery of exogenous DNA sequences in a mammal.
  12. Matulic-Adamic Jasenka ; Beigelman Leonid ; Karpeisky Alexander ; Jarvis Thale ; Usman Nassim ; DiRenzo Anthony ; Wincott Francine, Enzymatic nucleic acids containing 5'-and/or 3'-cap structures.
  13. Ide Masatake,JPX, Foot-pressure massage stand.
  14. Baulcombe, David Charles; Hamilton, Andrew John, Gene silencing.
  15. Baulcombe, David Charles; Hamilton, Andrew John, Gene silencing.
  16. Baulcombe, David Charles; Voinnet, Olivier; Lederer, Carsten Werner, Gene silencing methods.
  17. Graham, Michael Wayne, Genetic constructs for delaying or repressing the expression of a target gene.
  18. Fire, Andrew; Kostas, Stephen; Montgomery, Mary; Timmons, Lisa; Xu, SiQun; Tabara, Hiroaki; Driver, Samuel E.; Mello, Craig C., Genetic inhibition by double-stranded RNA.
  19. Draper Kenneth G. ; Chowrira Bharat ; McSwiggen James ; Stinchcomb Dan T. ; Thompson James D., HIV nef targeted ribozymes.
  20. Noonberg Sarah B. (Berkeley CA) Hunt C. Anthony (San Francisco CA), In vivo oligonucleotide generator, and methods of testing the binding affinity of triplex forming oligonucleotides deriv.
  21. Kreutzer, Roland; Limmer, Stefan, Method and medicament for inhibiting the expression of a given gene.
  22. Thompson Peter (Danville CA) Lund-Johannsen Fridjtof (Fremont CA), Method for identifying cells committed to apoptosis by determining cellular phosphotyrosine content.
  23. Francis P. Tally ; Jianshi Tao ; Philip A. Wendler ; Gene Connelly ; Paul L. Gallant ; Xiaoyu Shen ; Jiansu Zhang, Method for identifying validated target and assay combinations for drug development.
  24. Baulcombe, David Charles; Angell, Susan Mary, Methods and DNA constructs for gene silencing in transgenic plants.
  25. Tuschl,Thomas; Lagos Quintana,Marina; Lendeckel,Winfried; Meyer,Jutta; Rauhut,Reinhard, MicroRNA molecules.
  26. Eckstein Fritz (Gottingen DEX) Pieken Wolfgang (Boulder CO) Benseler Fritz (Gleichen/Etzborn DEX) Olsen David B. (West Point PA) Williams David M. (Cambridge GB2) Heidenreich Olaf (Gottingen DEX), Modified ribozymes.
  27. Bahramian, Mohammad B.; Zarbl, Helmut, Muting gene activity using a transgenic nucleic acid.
  28. Ts\o Paul O. P. (2117 Folkstone Rd. Lutherville MD 21093) Miller Paul S. (225 Hopkins Rd. Baltimore MD 21212), Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof.
  29. Inouye, Masayori, Nucleic acid constructs containing stable stem and loop structures.
  30. Wassenegger Michael,DEX ; Riedel Leonhard,DEX ; Schiebel Winfried,DEX ; Sanger Heinz L.,DEX, Nucleic acid molecules encoding polypeptides having the enzymatic activity of an RNA-directed RNA polymerase (RDRP).
  31. Draper Kenneth G. (Boulder CO) Crooke Stanley T. (Carlsbad CA) Mirabelli Christopher K. (Encinitas CA) Ecker David J. (Leucadia CA) Hanecak Ronnie C. (San Clemente CA) Anderson Kevin P. (Carlsbad CA), Oligonucleotide therapies for modulating the effects of herpes viruses.
  32. Crooke Stanley T., Oligoribonucleotides and ribonucleases for cleaving RNA.
  33. Crooke Stanley T., Oligoribonucleotides for cleaving RNA.
  34. Livache Thierry,FRX ; Fouque Brigitte,FRX ; Teoule Robert,FRX, Process for preparing double-stranded RNA, and its applications.
  35. Tuschl,Thomas; Elbashir,Sayda Mahgoub; Lendeckel,Winfried, RNA interference mediating small RNA molecules.
  36. Tuschl,Thomas; Elbashir,Sayda Mahgoub; Lendeckel,Winfried, RNA interference mediating small RNA molecules.
  37. Ledley Fred D. ; O'Malley ; Jr. Bert W., Somatic gene therapy to cells associated with fluid spaces.
  38. George Shaji T. ; Ma Michael ; Werner Martina ; Pace Umberto ; Goldberg Allan R., Stabilized external guide sequences.
  39. Kool Eric T. (Rochester NY), Stem-loop and circular oligonucleotides and method of using.
  40. Cook Phillip Dan (Carlsbad CA) Kawasaki Andrew Mamoro (Oceanside CA), Sugar modified oligonucleotides that detect and modulate gene expression.
  41. German Michael ; Goldfine Ira D. ; Rothman Stephen S., Systemic gene therapy by intestinal cell transformation.
  42. Carmichael Gordon G. ; Batt David B. ; Liu Zhong, Targeted RNA degradation using nuclear antisense RNA.
  43. Carter William A., Topically active compositions of mismatched dsRNAs.
  44. Verduijn Johannes Petrus,NLX ; Gellings Pieter Ernst,NLX, Zeolite L catalyst.

이 특허를 인용한 특허 (3)

  1. Tuschl, Thomas; Elbashir, Sayda Mahgoub; Lendeckel, Winfried, RNA interference mediating small RNA molecules.
  2. Tuschl, Thomas; Zamore, Phillip D.; Sharp, Phillip A.; Bartel, David P., RNA sequence-specific mediators of RNA interference.
  3. Templin, Michael V.; Vaish, Narendra K.; Polisky, Barry A.; Houston, Jr., Michael E., UNA oligomer structures for therapeutic agents.
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