Crosslinked human or animal tissue products and their methods of manufacture and use
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-038/39
A61F-002/02
A61F-002/08
A61L-027/36
A61L-027/24
출원번호
US-0560713
(2012-07-27)
등록번호
US-8901078
(2014-12-02)
발명자
/ 주소
Mezger, W. Jerry
Myers, Keith E.
출원인 / 주소
Harbor Medtech, Inc.
대리인 / 주소
Knobbe Martens Olson & Bear LLP
인용정보
피인용 횟수 :
0인용 특허 :
68
초록▼
Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based c
Degradable bioprostheses made of collagen-based material having amine-based and ester-based crosslinks are provided, as are methods for their formation and use. Some embodiments of the present invention are directed towards a method of controlling the ratio of amine-based crosslinks to ester-based crosslinks within a collagen-based material to provide a tailorably crosslinked collagen-based material. Some embodiments provide a method of making a degradable bioprosthesis involving controlling crosslinking to afford a degradable bioprosthesis that is partially crosslinked. By controlling the ratio of amine-based to ester-based crosslinks, by controlling the level of crosslinking, or by controlling both of these features, degradable bioprostheses with tailored degradation rates can be synthesized. Some embodiments of degradable bioprostheses have degradation rates that are tailored to allow their use in particular medical applications. Some embodiments are directed towards methods of use degradable bioprostheses in wound healing, tissue repair, and tissue supplementation.
대표청구항▼
1. A cross-linked collagen-based material comprising Crosslink A, Crosslink B, and free amines (—NH2): wherein: indicates collagen strands;R1 is R2 is R3 and R4 are independently selected from the group consisting of —CH2—O—(CH2)n—O—CH2— and —CH2—(O(CH2)n)m—O—CH2—,n and m are independently an intege
1. A cross-linked collagen-based material comprising Crosslink A, Crosslink B, and free amines (—NH2): wherein: indicates collagen strands;R1 is R2 is R3 and R4 are independently selected from the group consisting of —CH2—O—(CH2)n—O—CH2— and —CH2—(O(CH2)n)m—O—CH2—,n and m are independently an integer from 1-6, andthe amount of free amines (—NH2) on the collagen strands is between 50% and 85% relative to the total amount of free amines (—NH2) prior to crosslinking, and the ratio of Crosslink A and Crosslink B is from about 80:20 to about 20:80. 2. The crosslinked collagen-derived material of claim 1, wherein R3 and R4 are the same. 3. The crosslinked collagen-based material of claim 1, wherein the ratio of Crosslink A and Crosslink B is from about 170:30 to about 30:70. 4. The crosslinked collagen-derived material of claim 1, wherein the crosslinked collagen-derived material has a degradation rate between about 0.2% to about 1.1% per hour when subjected to a pronase digestion assay. 5. A degradable bioprosthesis, comprising: a cross-linked collagen-based material comprising Crosslink A, Crosslink B, and free amines (—NH2): wherein: indicates collagen strands;R1 is R2 is R3 and R4 are independently selected from the group consisting of —CH2—O—(CH2)n—O—CH2— and —CH2—(O(CH2)n)m—O—CH2—,n and m are independently an integer from 1-6, andthe amount of free amines (—NH2) on the collagen strands is between 50% and 85% relative to the total amount of free amines (—NH2) prior to crosslinking, and the ratio of Crosslink A and Crosslink B is from about 80:20 to about 20:80. 6. The crosslinked collagen-derived material of claim 5, wherein R3 and R4 are the same. 7. The crosslinked collagen-based material of claim 5, wherein the ratio of Crosslink A and Crosslink B is from about 70:30 to about 30:70. 8. The crosslinked collagen-derived material of claim 5, wherein the crosslinked collagen-derived material has a degradation rate between about 0.2% to about 1.1% per hour when subjected to a pronase digestion assay. 9. A degradable bioprosthesis comprising: a tailorable cross-linked collagen-based material comprising Crosslink A, Crosslink B, and free amines (—NH2): wherein: indicates collagen strands;R1 is R2 is R3 and R4 are independently selected from the group consisting of —CH2—O—(CH2)n—O—CH2— and —CH2—(O(CH2)n)m—O—CH2—,n and m are independently an integer from 1-6; andthe tailorable cross-linked collagen-based material has a degradation rate between 0.27% to 0.88% per hour when subjected to a pronase digestion assay. 10. The degradable bioprosthesis of claim 9, wherein the collagen strands are derived from animal pericardium. 11. The degradable bioprosthesis of claim 9, having a shrinkage temperature (Ts) above about 70° C. 12. The degradable bioprosthesis of claim 9, wherein the shrinkage temperature is inversely proportional to the amount of free amines on the collagen strands. 13. The degradable bioprosthesis of claim 9, wherein the amount of free amines on the collagen strands is between about 50% and about 85% relative to the total amount of free amines (—NH2) prior to crosslinking. 14. The degradable bioprosthesis of claim 9, wherein the degradation rate is directly proportional to the amount of free amines on the collagen strands. 15. The degradable bioprosthesis of claim 9, wherein the ratio of amine-based crosslinks to ester-based crosslinks is about 100:1 to about 1:100. 16. The degradable bioprosthesis of claim 9, wherein the degradable bioprosthesis comprises a flexible sheet. 17. The degradable bioprosthesis of claim 16, wherein the flexible sheet is between about 1 cm2 and about 500 cm2. 18. The degradable bioprosthesis of claim 16, wherein the flexible sheet is treated with antimicrobial agent.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (68)
Ahmed, Walid; Doshi, Bharat Tarachand; Jiang, Hong; Monogioudis, Pantelis; Rege, Kiran M., Address option for use in an internet protocol-based multimedia mobile network.
Ahmed, Walid; Doshi, Bharat Tarachand; Jiang, Hong; Monogioudis, Pantelis; Rege, Kiran M., Addressing techniques for use in an internet protocol-based multimedia mobile network.
Rhee Woonza M. ; Rao Prema R. ; Chu George H. ; DeLustro Frank A. ; Harner Carol F. H. ; Sakai Naomi ; Schroeder Jacqueline A., Biocompatible adhesive compositions.
Rhee Woonza M. ; Rao Prema R. ; Chu George H. ; DeLustro Frank A. ; Harner Carol F. H. ; Sakai Naomi ; Schroeder Jacqueline A., Biocompatible adhesive compositions.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Biologically inert, biocompatible-polymer conjugates.
Rhee Woonza M. (Palo Alto CA) Rao Prema R. (Los Gatos CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA), Clear, chemically modified collagen-synthetic polymer conjugates for ophthalmic applications.
Rhee Woonza M. (Palo Alto CA) Rao Prema R. (Los Gatos CA) Chu George H. (Cupertino CA) DeLustro Frank A. (Belmont CA) Harner Carol F. H. (Redwood Shores CA) Sakai Naomi (San Mateo CA) Schroeder Jacqu, Collagen-based bioadhesive compositions.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Collagen-polymer conjugates containing an ether linkage.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Composition for bone repair.
Rhee Woonza M. (3845 LaDonna Ave. Palo Alto CA 94306) Berg Richard A. (660 S. Springer Rd. Los Altos CA 94024), Glycosaminoglycan-synthetic polymer conjugates.
Eberhardt, Carol E.; Toomes, Christopher G.; Capps, Mark J; Millwee, Billie; Shay, Janice; Hessler, Tom; Kalam, Faisal, Heart valve fixation process and apparatus.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Implants coated with collagen-polymer conjugates.
Carter, Kevin C.; Carter, legal representative, Diane; Esch, Michael; LaRochelle, Paul; Scurti, Gina, Materials and methods for improved bone tendon bone transplantation.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Method of augmenting tissue using collagen-polymer conjugates.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Method of augmenting tissue with collagen-polymer conjugates.
Tu Roger (Tustin CA) Wang Edwin (Irvine CA) Kuo Chris (Irvine CA) Hata Cary (Alhambra CA), Method of manufacturing pliable biological grafts materials.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Method of preparing collagen-polymer conjugates.
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Tefft Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA), Method of preparing crosslinked biomaterial compositions for use in tissue augmentation.
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Tefft Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA), Method of preparing crosslinked biomaterial compositions for use in tissue augmentation.
Rhee Woonza M. ; Rao Prema R. ; Chu George H. ; DeLustro Frank A. ; Harner Carol F. H. ; Sakai Naomi ; Schroeder Jacqueline A., Method of preventing formation of adhesions following surgery.
Hendriks,Marc; Everaerts,Frank; Gillissen,Mirian; Verhoeven,Michel; Torrianni,Mark W., Methods of preparing crosslinked materials and bioprosthetic devices.
Hu Can B. ; Myers Keith E. ; Nguyen-Thien-Nhon Diana ; Kafesjian Ralph, Nonpolymeric epoxy compounds for cross linking biological tissue and bioprosthetic grafts prepared thereby.
Rhee Woonza (Palo Alto CA) Wallace Donald G. (Menlo Park CA) Michaels Alan S. (Boston MA) Burns ; Jr. Ramon A. (Fremont CA) Fries Louis (Los Altos CA) DeLustro Frank (Belmont CA) Bentz Hanne (Newark , Polymer conjugates ophthalmic devices comprising collagen-polymer conjugates.
Hendriks Marc,NLX ; Michel Verhoeven,NLX ; Cahalan Patrick,NLX ; Torrianni Mark W. ; Cahalan Linda,NLX ; Fouache Benedicte,FRX, Process for making a bioprosthetic device.
Hendriks Marc,NLX ; Verhoeven Michel,NLX ; Cahalan Patrick,NLX ; Zeeman Raymond,NLX ; Dijkstra Piet,NLX ; Feijen Jan,NLX, Process for making a bioprosthetic device and implants produced therefrom.
Rhee Woonza M. (Palo Alto CA) Berg Richard A. (Los Altos CA) Rosenblatt Joel S. (Palo Alto CA) Schroeder Jacqueline A. (Redwood City CA) Braga Larry J. (Fremont CA) Smestad Thomas L. (Palo Alto CA) F, Process for preparing a sterile, dry crosslinking agent.
Lang Hans-Jochen,DEX ; Weichert Andreas,DEX ; Kleemann Heinz-Werner,DEX ; Schwark Jan-Robert,DEX ; Scholz Wolfgang,DEX ; Albus Udo,DEX, Substituted benzoylguanidines, process for their preparation, their use as a pharmaceutical as inhibitors of the cellula.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.