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Two piece cancellous construct for cartilage repair 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • A61F-002/28
  • A61L-027/36
  • A61L-027/38
  • A61L-027/54
  • A61F-002/30
  • A61F-002/46
  • A61B-017/00
  • A61F-002/38
출원번호 US-0881988 (2010-09-14)
등록번호 US-8906110 (2014-12-09)
발명자 / 주소
  • Semler, Eric J.
  • Truncale, Katherine G.
  • Callahan, Alex B.
  • Yannariello-Brown, Judith I.
출원인 / 주소
  • Musculoskeletal Transplant Foundation
대리인 / 주소
    Greenberg Traurig, LLP
인용정보 피인용 횟수 : 0  인용 특허 : 442

초록

The invention is directed toward a cartilage repair assembly comprising a shaped allograft two piece construct with a demineralized cancellous cap and a mineralized cylindrical base member defining a blind bore with a through-going transverse bore intersecting the blind bore. The demineralized cance

대표청구항

1. In a multi-component construct for cartilage and bone repair, said construct having an outer periphery whose size and shape are selected such that said construct is positionable in a defect site to be repaired, said construct including a cap member shaped to form a stem having a longitudinal axis

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  188. Grooms,Jamie M.; Carter,Kevin C.; Sander,Tom; Dulebohn,David H., Intervertebral spacers.
  189. Kizer, Neil; Spiro, Robert; Yao, Jian; Blanchard, Cheryl Renee, Juvenile cartilage composition.
  190. Stiles, Terri Lynn, Kolla2-desiccated avian sternal cartilage powder.
  191. Trml Pertti (Reikonkatu 7 C 7 SF-33730 Tampere FIX) Vainionp Seppo (Orapihlajatie 21-27 B 12 SF-00320 Helsinki FIX) Rokkanen Pentti (Marjaniemenranta 29 SF-00930 Helsinki FIX) Helevirta Pertti (Ojava, Layered surgical biocomposite material.
  192. Bruder Scott P. ; Caplan Arnold I. ; Haynesworth Stephen E., Lineage-directed induction of human mesenchymal stem cell differentiation.
  193. Todd M. Boyce ; Lawrence A. Shimp ; Albert Manrique, Load bearing osteoimplant and method of repairing bone using the same.
  194. Boyce Todd M. ; Shimp Lawrence A. ; Manrique Albert, Load-bearing osteoimplant, method for its manufacture and method of repairing bone using same.
  195. Drapeau, Susan J.; Chamness, Kathy L.; McKay, William F., Malleable implants containing demineralized bone matrix.
  196. Drapeau, Susan J; Remsen, Kathy L; McKay, William F, Malleable implants containing demineralized bone matrix.
  197. Drapeau, Susan J; Remsen, Kathy L; McKay, William F; Scarborough, Nelson L, Malleable implants containing demineralized bone matrix.
  198. Gertzman Arthur A. ; Sunwoo Moon Hae, Malleable paste for filling bone defects.
  199. Gertzman, Arthur A.; Sunwoo, Moon Hae, Malleable paste for filling bone defects.
  200. Gertzman,Arthur A.; Sunwoo,Moon Hae, Malleable paste for filling bone defects.
  201. Arthur A. Gertzman ; Moon Hae Sunwoo, Malleable paste with allograft bone reinforcement for filling bone defects.
  202. Arthur A. Gertzman ; Moon Hae Sunwoo, Malleable paste with high molecular weight buffered carrier for filling bone defects.
  203. Gertzman, Arthur A.; Sunwoo, Moon H., Malleable putty and flowable paste with allograft bone having residual calcium for filling bone defects.
  204. Khouri Roger K. ; Sampath Kuber T. ; Rueger David C., Manufacture of autogenous replacement body parts.
  205. Khouri Roger K. ; Sampath Kuber T. ; Rueger David C., Manufacture of autogenous replacement body parts.
  206. Kevin C. Carter ; Michael Esch ; Paul LaRochelle, Materials and methods for improved bone tendon bone transplantation.
  207. Villeneuve Peter E., Materials for healing cartilage and bone defects.
  208. Khouri Roger K. ; Sampath Kuber T. ; Rueger David C., Matrix for the manufacture of autogenous replacement body parts.
  209. Bishopric Nanette H. ; Dousman Linda ; Yao Yung-mae M., Matrix substrate for a viable body tissue-derived prosthesis and method for making the same.
  210. Rueger David C. ; Tucker Marjorie M., Matrix-free osteogenic devices, implants and methods of use thereof.
  211. Kurland Kenneth Z. (2 W. McCabe Rd. El Centro CA 92243), Means and method of implanting bioprosthetics.
  212. Geistlich, Peter; Eckmayer, Zdenek; Schlösser, Lothar, Membrane for in guided tissue regeneration.
  213. Li Shu-Tung (Oakland NJ) Stone Kevin R. (Mill Valley CA), Meniscal augmentation device.
  214. John Rivera ; Son Le ; Daniel Cheek ; Richard Matt ; Roger P. Kaminski, Method and apparatus for sequestering platelet rich plasma.
  215. Marc J. Philippon, Method and apparatus for treating osteochondral pathologies.
  216. Hunziker Ernst B. (Riedholz CHX), Method and compositions for the treatment and repair of defects or lesions in cartilage.
  217. Bell Eugene, Method and construct for producing graft tissue from an extracellular matrix.
  218. Bell Eugene, Method and construct for producing graft tissue from extracellular matrix.
  219. Brekke John H. ; Coutts Richard D., Method and device for reconstruction of articular cartilage.
  220. McDowell Charles L., Method and device for regenerating cartilage in articulating.
  221. Schmieding,Reinhold, Method and instrumentation for osteochondral repair using preformed implants.
  222. Vibe-Hansen Henrik,DKX ; Lundegaard Charlotte,DKX ; Osther Kurt B., Method and kit for autologous transplantation.
  223. Stone Kevin R., Method and paste for articular cartilage transplantation.
  224. Stone Kevin R., Method and paste for articular cartilage transplantation.
  225. Adkisson,Huston Davis; Milliman,Curt L., Method for chondrocyte expansion with phenotype retention.
  226. Frondoza, Carmelita G.; Hungerford, David S.; Shikani, Alan H.; Domb, Abraham J.; Fink, David J.; Bloom, Leonard, Method for composite cell-based implants.
  227. Kamarei Ahmad R. (Arlington MA) Sinn Robert (New York NY), Method for extracting a substance from animal derived material.
  228. Nelson L. Scarborough ; John W. Boyle, Method for forming an intervertebral implant.
  229. Vignery, Agnes; Mehta, Nozer M.; Gilligan, James P., Method for fostering bone formation and preservation.
  230. Vignery, Agnès; Mehta, Nozer M.; Gilligan, James P., Method for fostering bone formation and preservation.
  231. Rieser Franz,CHX ; Muller Werner,CHX ; Bittmann Pedro,CHX ; Mainil-Varlet Pierre,CHX ; Saager Christoph P.,CHX, Method for making cartilage and implants.
  232. Oommen,Paul P., Method for over the air mobile station management.
  233. Mizuno, Shuichi; Tokuno, Toshimasa; Berlowitz Tarrant, Laurence J., Method for preparing an implantable multilayer tissue construct.
  234. Mizuno, Shuichi; Kusanagi, Akihiko; Tarrant, Laurence J. B.; Tokuno, Toshimasa; Smith, Robert Lane, Method for preparing and implanting a cartilage construct to treat cartilage lesions.
  235. Schmieding, Reinhold, Method for preparing and inserting round, size specific osteochondral cores in the knee.
  236. Livesey Stephen A. (Eltham TX AUX) del Campo Anthony A. (Houston TX) Nag Abhijit (Houston TX) Nichols Ken B. (The Woodlands TX) Coleman Christopher (Houston TX), Method for processing and preserving collagen-based tissues for transplantation.
  237. Franz Rieser CH; Werner Muller CH; Pedro Bittmann CH; Pierre Mainil-Varlet CH; Christoph P. Saager CH, Method for producing cartilage tissue and implants for repairing enchondral and osteochondral defects as well as arrangement for carrying out the method.
  238. Goodwin Thomas J. (Friendswood TX) Wolf David A. (Houston TX) Spaulding Glenn F. (Houston TX) Prewett Tacey L. (Friendswood TX), Method for producing non-neoplastic, three dimensional, mammalian tissue and cell aggregates under microgravity culture.
  239. Lou Blasetti ; Sherwin V. Kevy, Method for producing platelet rich plasma and/or platelet concentrate.
  240. Lazarov, Mirella; Middleton Hardie, Catherine; Rosen, David, Method for promoting hard tissue formation.
  241. Myron Spector, Method for promoting regeneration of surface cartilage in a damage joint.
  242. Geistlich,Peter; Schloesser,Lothar, Method for promoting regeneration of surface cartilage in a damaged joint using multi-layer covering.
  243. Gendler El, Method for reconstituting cartilage tissue using demineralized bone and product thereof.
  244. Mizuno,Shuichi; Kusanagi,Akihiko; Tarrant,Laurence J. B.; Tokuno,Toshimasa; Smith,Robert Lane, Method for repair of cartilage lesions.
  245. Naughton Gail K. ; Willoughby Jane, Method for repairing cartilage.
  246. Caplan Arnold I. (1300 Oakridge Dr. Cleveland Heights OH 44121) Haynesworth Stephen E. (3643 Antisdale Rd. Cleveland Heights OH 44118), Method for treating connective tissue disorders.
  247. Kusanagi,Akihiko; Schmidt,Mary Beth; Tarrant,Laurence J. B., Method for treatment and repair of meniscal injuries.
  248. Henrik Vibe-Hansen DK; Charlotte Lundsgaard DK; Kurt B. Osther ; Ahmed Idouraine, Method instruments and kit for autologous transplantation.
  249. Heidaran, Mohammad A.; Daverman, Robin, Method of inducing or enhancing chondrogenesis with extracellular matrix containing BMP-4.
  250. Heidaran,Mohammad A.; Spiro,Robert C.; Daverman,Robin; Liu,LinShu, Method of inducing or enhancing chondrogenesis with extracellular matrix containing GDF-5.
  251. Khouri Roger K. (St. Louis MO) Reddi A. Harri (Bethesda MD), Method of making live autogenous skeletal replacement parts.
  252. Plouhar Pamela L. ; Dunn Michael D. ; Lower Jerry L. ; May Thomas C., Method of making reconstructive SIS structure for cartilaginous elements in situ.
  253. Ikeda Hideaki,JPX ; Murakami Toshikazu,JPX ; Kodama Haruki,JPX ; Matsue Yasutaka,JPX ; Shinohara Takao,JPX, Method of manufacturing connecting rod.
  254. Yao, Jian Q.; Zaporojan, Victor, Method of obtaining viable small tissue particles and use for tissue repair.
  255. Yao, Jian Q; Zaporojan, Victor, Method of obtaining viable small tissue particles and use for tissue repair.
  256. Balassa Leslie L. (Blooming Grove NY), Method of processing animal cartilage.
  257. Hu Jie, Method of producing a biological extracellular matrix for use as a cell seeding scaffold and implant.
  258. Lindner Adolf (Vienna ATX) Linnau Yendra (Vienna ATX), Method of producing a tissue adhesive.
  259. Campbell Todd D. (Corona CA) Nashef Aws S. (Costa Mesa CA), Method of producing prostheses for replacement of articular cartilage and prostheses so produced.
  260. Juergensen Kay,CHX ; Aeschlimann Daniel,CHX ; Hunziker Ernst B.,CHX, Method of promoting adhesion between tissue surfaces.
  261. Radomsky Michael, Method of promoting bone growth with hyaluronic acid and growth factors.
  262. Walter Mary Ann ; Leatherbury Neil C. ; Niederauer Mark Q., Method of resurfacing a femoral condyle.
  263. Schmieding, Reinhold, Method of selling procedure specific allografts and associated instrumentation.
  264. Bonutti, Peter M., Method of transplanting human body tissue.
  265. Kizer, Neil; Spiro, Robert; Yao, Jian; Blanchard, Cheryl Renee, Method of treating an osteochondral defect.
  266. Balassa Leslie L. (Blooming Grove NY), Method of treating degenerative joint afflictions.
  267. Franco Wayne P. (79 Two Stone Dr. Wethersfield CT 06109), Method of treating the heart for myocardial infarction.
  268. Yannas Ioannis V. (Newton Center MA) Burke John F. (Belmont MA), Method of using a fibrous lattice.
  269. Bonutti, Peter M., Method of using body tissue.
  270. Delmotte Yves,BEX ; Krack Genevieve,BEX, Method of using cross-linked fibrin material.
  271. Bonutti Peter M., Method of using human tissue with a tissue press and system.
  272. Bonutti Peter M. (1303 W. Evergreen Plz. Effingham IL 62401), Method using human tissue.
  273. Vibe-Hansen Henrik,DKX ; Lundsgaard Charlotte,DKX ; Osther Kurt B. ; Idouraine Ahmed, Method, instruments and kit for autologous transplantation.
  274. Asculai, Samuel S.; Idouraine, Ahmed; Giannetti, Bruno, Method, instruments, and kit for autologous transplantation.
  275. Asculai,Samuel S.; Idouraine,Ahmed; Giannetti,Bruno, Method, instruments, and kit for autologous transplantation.
  276. Vibe-Hansen Henrik,DKX ; Lundsgaard Charlotte,DKX ; Osther Kurt B. ; Idouraine Abmed, Method, instruments, and kit for autologous transplantation.
  277. Vibe-Hansen, Henrik; Lundsgaard, Charlotte; Osther, Kurt B.; Idouraine, Ahmed, Method, instruments, and kit for autologous transplantation.
  278. Vibe-Hansen, Henrik; Lundsgaard, Charlotte; Osther, Kurt B.; Idouraine, Ahmed, Method, instruments, and kit for autologous transplantation.
  279. Vibe-Hansen, Henrik; Lundsgaard, Charlotte; Osther, Kurt B.; Idouraine, Ahmed, Method, instruments, and kit for autologous transplantation.
  280. Vibe-Hansen, Henrik; Lundsgaard, Charlotte; Osther, Kurt B.; Idouraine, Ahmed, Method, instruments, and kit for autologous transplantation.
  281. Vibe Hansen,Henrik; Lundsgaard,Charlotte; Osther,Kurt B.; Idouraine,Ahmed, Method, instruments, and kits for autologous transplantation.
  282. Lang, Philipp; Steines, Daniel; Tsourgarakis, Konstantinos, Methods and compositions for articular repair.
  283. Lang,Philipp; Steines,Daniel; Timsari,Bijan; Tsougarakis,Konstantinos, Methods and compositions for articular repair.
  284. Gazit, Dan; Zilberman, Yoram; Turgeman, Gadi; Pelled, Gadi; Gross, Gerhard; Czichos, Stefan; Hoffmann, Andrea, Methods and compositions for enhancing cartilage repair.
  285. Zhang, Renwen; Peluso, Diane; Morris, Elisabeth, Methods and compositions for healing and repair of articular cartilage.
  286. Zhang,Renwen; Peluso,Diane; Morris,Elisabeth, Methods and compositions for healing and repair of articular cartilage.
  287. Anthony Atala, Methods and compositions for organ decellularization.
  288. Ashkar Samy ; Atala Anthony, Methods and compositions for programming an organic matrix for remodeling into a target tissue.
  289. Ciombor,Deborah McK.; Aaron,Roy K., Methods and compositions for repairing cartilage.
  290. Tubo Ross A. ; Barone Leesa M. ; Wrenn Courtney A., Methods and compositions for the repair of articular cartilage defects in mammals.
  291. Tubo Ross A. ; Barone Leesa M. ; Wrenn Courtney A., Methods and compositions for the repair of articular cartilage defects in mammals.
  292. Hunziker Ernst B. (Riedholz CHX), Methods and compositions for the treatment and repair of defects or lesions in cartilage.
  293. Hunziker Ernst B. (Riedholz CHX), Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone.
  294. Hunziker Ernst B.,CHX, Methods and compositions for the treatment and repair of defects or lesions in cartilage or bone using functional barrie.
  295. Rodgers Kathleen E. ; DiZerega Gere S., Methods for accelerating bone and cartilage growth and repair.
  296. John W. Morris ; Lawrence A. Shimp ; Mark P. Daughterty, Methods for manufacturing skeletal implants.
  297. Bell Eugene ; Fofonoff Timothy W., Methods for preparing biopolymer foams.
  298. Marx Gerard (New York NY), Methods for tissue embedding and tissue culturing.
  299. Strzepa, Peter; Cook, Stephen D., Methods of use of cartilage implants.
  300. Sah,Robert L.; Li,Kelvin W.; Klein,Travis J.; Schumacher,Barbara L.; Masuda,Koichi; Thonar,Eugene J M. A., Methods to engineer stratified cartilage tissue.
  301. Giannetti, Bruno; Behrens, Peter; Asculai, Samuel, Methods, instruments and materials for chondrocyte cell transplantation.
  302. Kurokawa Tsutomu (Kawanishi JPX) Kuroshima Ken-ichi (Osaka JPX) Yoshitomi Sumie (Osaka JPX) Seko Chisako (Osaka JPX), Modified GAF polypeptides.
  303. Walter Mary Ann ; Leatherbury Neil C. ; Niederauer Mark Q., Moldable, hand-shapable biodegradable implant material.
  304. Walter Mary Ann ; Leatherbury Neil C. ; Niederauer Mark Q., Moldable, hand-shapable biodegradable implant material.
  305. Gordon, Jeffrey D.; Fisher, Michael G.; Johnson, Paul R.; Johannaber, Kenneth D., Monolithic orthopedic implant with an articular finished surface.
  306. Hiles, Michael C.; Patel, Umesh H., Multi-formed collagenous biomaterial medical device.
  307. Plouhar Pamela L. ; Dunn Michael D. ; Lower Jerry L. ; May Thomas C., Multi-layered SIS tissue graft construct for replacement of cartilaginous elements in situ.
  308. Li Shu-Tung (Oakland NJ), Multi-layered, semi-permeable conduit for nerve regeneration.
  309. Athanasiou Kyriacos A. (Helotes TX) Boyan Barbara D. (San Antonio TX), Multi-phase bioerodible implant/carrier and method of manufacturing and using same.
  310. Pachence James M. ; Frenkel Sally ; Menche David, Multi-stage collagen-based template or implant for use in the repair of cartilage lesions.
  311. Borenstein,Jeffrey T.; King,Kevin R.; Terai,Hidetomi; Vacanti,Joseph P., Multilayer device for tissue engineering.
  312. Yannas Ioannis V. (Newton Center MA) Burke John F. (Belmont MA) Gordon Philip L. (Lexington MA) Huang Chor (Avon Lake OH), Multilayer membrane useful as synthetic skin.
  313. Messerli, Dominique; Myer, Jacqueline; Boyer, II, Michael L.; Angelucci, Christopher H., Multipiece allograft implant.
  314. Messerli,Dominique; Myer,Jacqueline; Boyer, II,Michael L.; Angelucci,Christopher H., Multipiece allograft implant.
  315. Boyer, II,Michael L.; Paul,David C.; Higgins,Thomas B., Multipiece implants formed of bone material.
  316. Pauley Robin G. ; McLarty Donna L. ; Khare Atul R. ; Sternberg Shmuel ; Boggs Daniel R. ; Neuenfeldt Steven ; Jones Mark ; Brauker James H. ; Martinson Laura A., Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue.
  317. Geddes Leslie A. ; Badylak Stephen F. ; Matheny Robert G. ; Schoenlein William E. ; Obermiller Fred J. ; Havel William J., Myocardial graft constructs.
  318. Adkisson Huston D., Neocartilage and methods of use.
  319. Vacanti Joseph P. (Winchester MA) Vacanti Charles A. (Lexington MA) Langer Robert S. (Newton MA), Neomorphogenesis of cartilage in vivo from cell culture.
  320. Malinin, Theodore I., Osteochondral allografts.
  321. Cerundolo, Daniel G., Osteochondral transplant techniques.
  322. Daniel G. Cerundolo, Osteochondral transplant techniques.
  323. O\Leary Robert K. (Spring Lake NJ) Prewett Annamarie B. (Little Silver NJ), Osteogenic composition and implant containing same.
  324. Oppermann Hermann (Medway MA) Ozkaynak Engin (Milford MA) Kuberasampath Thangavel (Medway MA) Rueger David C. (Hopkinton MA) Pang Roy H. L. (Medway MA), Osteogenic devices.
  325. Rueger,David C.; Tucker,Marjorie M., Osteogenic devices and methods of use thereof for repair of endochondral bone and osteochondral defects.
  326. Boyce, Todd M.; Kaes, David; Scarborough, Nelson L., Osteogenic implants derived from bone.
  327. Boyce Todd M. ; Manrique Albert, Osteoimplant and method for its manufacture.
  328. Edwards, Jean T.; Shimp, Lawrence A.; Diegmann, Michele; Boyce, Todd M.; Scarborough, Nelson L.; Russell, James L., Osteoimplant and method for making same.
  329. Edwards,Jean T.; Shimp,Lawrence A.; Diegmann,Michele; Boyce,Todd M.; Scarborough,Nelson L.; Russell,James L., Osteoimplant and method for making same.
  330. Arthur A. Gertzman ; Moon Hae Sunwoo, Partially demineralized cortical bone constructs.
  331. Griffey, Edward S.; Livesey, Stephen A.; Schiff, Charles M.; Boerboom, Lawrence E., Particulate acellular tissue matrix.
  332. Griffey,Edward S.; Livesey,Stephen A.; Schiff,Charles M.; Boerboom,Lawrence E., Particulate acellular tissue matrix.
  333. Bosley, Jr., Rodney W.; Fette, Clay; Tullius, Robert S., Particulate tissue graft with components of differing density and methods of making and using the same.
  334. Anderson, Janelle R.; Chiu, Daniel T.; Jeon, Noo-Li; Huang, Sui; Kane, Ravi; Choi, Insung S.; Ingber, Donald E.; Whitesides, George M., Patterning of surfaces utilizing microfluidic stamps including three-dimensionally arrayed channel networks.
  335. Whitson Bryan ; Cheng Boyle ; Badylak Stephen F., Perforated submucosal tissue graft constructs.
  336. Yayon,Avner; Glicklis,Rachel, Plasma protein matrices and methods for their preparation.
  337. Frey Otto (Winterthur CHX) Semlitsch Manfred (Winterthur CHX) Weber Heinz (Winterthur CHX), Plastic bone implant having a reinforced contact surface.
  338. Wolfinbarger ; Jr. Lloyd ; O'Leary Robert K. ; Anderson Billy G., Plasticized bone and soft tissue grafts and methods of making and using same.
  339. Boyer, II, Michael L.; Paul, David C.; Higgins, Thomas B.; Angelucci, Christopher M.; Messerli, Dominique D.; Kobayashi, Kenneth I., Plugs for filling bony defects.
  340. Arakawa Tsutomu ; Danilenko Dimitry Michael ; Itoh Nobuyuki,JPX ; Martin Francis Hall, Polynucleotides encoding hepatocyte-specific members of the FGF family.
  341. Malaviya,Prasanna; Schwartz,Herbert E.; Plouhar,Pamela L.; Orban,Janine M., Porous delivery scaffold and method.
  342. Frey Otto (Winterthur CHX) Semlitsch Manfred (Winterthur CHX) Weber Heinz (Winterthur CHX), Porous metal overlay for an implant surface.
  343. Yayon,Avner; Barkay,Hilla; Azachi,Malkit, Porous plasma protein matrices and methods for preparation thereof.
  344. Vyakarnam Murty N. ; Zimmerman Mark C. ; Scopelianos Angelo George ; Roller Mark B. ; Gorky David V., Porous tissue scaffoldings for the repair of regeneration of tissue.
  345. Vyakarnam, Murty N.; Zimmerman, Mark C.; Scopelianos, Angelo George; Roller, Mark B.; Gorky, David V., Porous tissue scaffoldings for the repair or regeneration of tissue.
  346. Nadler, Daniel; Bittmann, Pedro; Akens, Margarete K.; Von Rechenberg, Brigitte; Auer, Jorg, Preparation for repairing cartilage defects or cartilage/bone defects in human or animal joints.
  347. Nadler, Daniel; Bittmann, Pedro; Akens, Margarete; Rechenberg, Brigitte; Auer, J?rg, Preparation for repairing cartilage defects or cartilage/bone defects in human or animal joints.
  348. Morse Brenda S. (Chamblee GA) Dioh Clement D. (Marietta GA), Preparation of bone for transplantation.
  349. Mullis Kary B. (Kensington CA), Process for amplifying nucleic acid sequences.
  350. Mullis Kary B. (La Jolla CA) Erlich Henry A. (Oakland CA) Gelfand David H. (Oakland CA) Horn Glenn (Emeryville CA) Saiki Randall K. (Richmond CA), Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme.
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  352. O\Leary Robert K. (Spring Lake NJ) Prewett Ann (Fairhaven NJ), Process for cryopreserving biological materials and materials prepared thereby.
  353. Wolfinbarger, Jr., Lloyd; Lange, Perry; Linhurst, Alyce; Moore, Eric; Nolf, Barry, Process for decellularizing soft-tissue engineered medical implants, and decellularized soft-tissue medical implants produced.
  354. Bagby George W. (Spokane WA), Process for fusing bone joints.
  355. Klement Petr (Toronto CAX) Wilson Gregory J. (Toronto CAX) Yeger Herman (Richmond Hill CAX), Process for preparing biological mammalian implants.
  356. Prewett Annamarie B. (Little Silver NJ) Stikeleather Roger C. (Doylestown PA), Process for producing flowable osteogenic composition containing demineralized bone particles.
  357. Wolfinbarger ; Jr. Lloyd, Process for producing osteoinductive bone, and osteoinductive bone produced thereby.
  358. Wolfinbarger ; Jr. Lloyd, Process for producing osteoinductive bone, and osteoinductive bone produced thereby.
  359. Caplan Arnold (1300 Oakridge Dr. Cleveland Heights OH 44121) Syftestad Glenn T. (3660 Warrensville Center Rd. #101 Shaker Heights OH 44122), Process of and material for stimulating growth of cartilage and bony tissue at anatomical sites.
  360. Thiele Heinrich (Neue Universitaet Kiel DEX) Thiele Erhard (Reventlow-Allee 9 23 Kiel DEX), Process of degrading and regenerating bone and tooth material and products.
  361. Stone Kevin R. (Mill Valley CA) Li Shu-Tung (Oakland NJ), Prosthetic articular cartilage.
  362. Stone Kevin R. (Mill Valley CA) Li Shu-Tung (Oakland NJ), Prosthetic articular cartilage.
  363. Hakamatsuka Yasuharu (Akishima JPX) Irie Hiroyuki (Hachioji JPX), Prosthetic artificial bone having ceramic layers of different porosity.
  364. Bolesky Richard C. (Warsaw IN) Farling Gene M. (Warsaw IN) Gold Barry L. (Warsaw IN), Prosthetic device adapted to promote bone/tissue ingrowth.
  365. Stone Kevin R. (133 Retiro Way San Francisco CA 94123), Prosthetic meniscus.
  366. Stone Kevin R. (San Francisco CA), Prosthetic meniscus.
  367. Lazarov, Mirella; Middleton Hardie, Catherine; Rosen, David, Protein formulation for promoting hard tissue formation.
  368. Stone Kevin R., Proteoglycan-reduced soft tissue xenografts.
  369. Thorne, Kevin; Akella, Rama, Rapid isolation of osteoinductive protein mixtures from mammalian bone tissue.
  370. Fiddes John C. (Palo Alto CA) Abraham Judith A. (Sunnyvale CA), Recombinant human basic fibroblast growth factor.
  371. Kandel Rita A. (Toronto CAX), Reconstituted cartridge tissue.
  372. Brennan H. George (1137 Granville Newport Beach CA 92660), Reconstructive surgery method and implant.
  373. Kadiyala, Sudhakar; Bruder, Scott P., Regeneration and augmentation of bone using mesenchymal stem cells.
  374. McKay William F., Reinforced bone graft substitutes.
  375. Nevo Zvi (Herzlia ILX) Itay Samuel (Kfar Saba ILX), Repair of cartilage and bones.
  376. Seedhom, Bahaa Botros; Lorrison, Jonathan Charles, Repair of damaged tissue on a bone site.
  377. Torrie Paul A. ; Ferragamo Michael C. ; Blough Rebecca ; Miniaci Anthony,CAX ; Hangody Lazlo,HUX ; Karparti Zoltan,HUX, Repairing cartilage.
  378. Mansmann, Kevin A., Resorbable scaffolds to promote cartilage regeneration.
  379. Lemperle, Stefan M.; Calhoun, Christopher J., Resorbable, macro-porous non-collapsing and flexible membrane barrier for skeletal repair and regeneration.
  380. Lemperle Stephan M. ; Calhoun Christopher J., Resorbable, macro-porous, non-collapsing and flexible membrane barrier for skeletal repair and regeneration.
  381. Boyan Barbara D. ; Schwartz Zvi,ILX, Resurfacing cartilage defects with chondrocytes proliferated without differentiation using platelet-derived growth factor.
  382. David W. Overaker, Scaffold fixation device for use in articular cartilage repair.
  383. Nevo, Zvi; Robinson, Dror, Scaffold formed of tissue treated to eliminate cellular and cytosolic elements.
  384. Grooms, Jamie M.; Carter, Kevin C.; Sander, Thomas W.; Buskirk, Dayna; Bianchi, John, Segmentally demineralized bone implant.
  385. mune Responses" ; Cell ; 80:321-330 ; Jan. 27 ; 1995., Segmentally demineralized bone implant.
  386. Stroever Bruce W. ; Rainey Thomas P., Serrated bone graft.
  387. Boyce, Todd M.; Shimp, Lawrence; Manrique, Albert; Winterbottom, John M., Shaped load-bearing osteoimplant and methods of making same.
  388. Dowd Michael (Bordentown NJ) Dyke Denis G. (Long Branch NJ), Shaped materials derived from elongate bone particles.
  389. Prewett Annamarie B. (Little Silver NJ) Stikeleather Roger C. (Doylestown PA) Bogdansky Simon (Marlboro NJ) O\Leary Robert K. (Spring Lake NJ), Shaped, swollen demineralized bone and its use in bone repair.
  390. Prewett Annamarie B. (Little Silver NJ) Stikeleather Roger C. (Doylestown PA) Bogdansky Simon (Marlboro NJ) O\Leary Robert K. (Spring Lake NJ), Shaped, swollen demineralized bone and its use in bone repair.
  391. Buskirk, Dayna; Seid, Chris; Wironen, John F.; Gross, James M.; Scurti, Gina, Soft and calcified tissue implants.
  392. Buskirk, Dayna; Seid, Christopher A.; Wironen, John F.; Gross, James M.; Scurti, Gina, Soft and calcified tissue implants.
  393. Shimp, Lawrence A.; Winterbottom, John M.; Kaes, David R.; Boyce, Todd M.; Martz, Erik O., Spinal intervertebral implant, interconnections for such implant and processes for making.
  394. Carney, Darrell H.; Crowther, Roger S.; Stiernberg, Janet; Bergmann, John, Stimulation of cartilage growth with agonists of the non-proteolytically activated thrombin receptor.
  395. Badylak Stephen F. (W. Lafayette IN) Boder George (Martinsville IN) Voytik Sherry (Lafayette IN) Demeter Robert J. (Mooresville IN) Critser John (Carmel IN) Liu Chi (Indianapolis IN), Submucosa as a growth substrate for islet cells.
  396. MacPhee,Martin J.; Drohan,William N.; Liau,Gene; Nunez,Hernan; Burgess,Wilson H.; Hollinger,Jeffrey O.; Maciag,Thomas, Supplemented and unsupplemented tissue sealants, methods of their production and use.
  397. Seddon Andrew P. (Monroe NY) Li Luyuan (New City NY) Bhlen Peter (Peekskill NY) Eisinger Magdalena (Demarest NJ) Yayon Avner (Moshav Sitra ILX), Surface loop structural analogues of fibroblast growth factors.
  398. Schwartz Robert E. (Old Westbury NY), Surgical implantation of cartilage repair unit.
  399. Fell,Barry M., Surgically implantable knee prosthesis.
  400. Fell,Barry M.; Hallock,Richard H., Surgically implantable knee prosthesis.
  401. Tallarida, Steven J.; Ek, Steven W., System and method for joint resurface repair.
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  435. Johnson, Lanny L., Use of autologous sediment from fluid aspirates as vehicles for drug delivery.
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