IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0138279
(2010-01-29)
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등록번호 |
US-8910633
(2014-12-16)
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국제출원번호 |
PCT/CA2010/000134
(2010-01-29)
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§371/§102 date |
20111215
(20111215)
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국제공개번호 |
WO2010/085895
(2010-08-05)
|
발명자
/ 주소 |
|
출원인 / 주소 |
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
2 인용 특허 :
4 |
초록
▼
Gas leakage from a ventilator circuit and patient interface is estimated by a method that relies on breath-by-breath or time-to-time variability in the pattern of pressure delivery by the ventilator, comprising generating signals that correspond to pressure (PCIRCUIT) and flow rate (Flow) in the ven
Gas leakage from a ventilator circuit and patient interface is estimated by a method that relies on breath-by-breath or time-to-time variability in the pattern of pressure delivery by the ventilator, comprising generating signals that correspond to pressure (PCIRCUIT) and flow rate (Flow) in the ventilator circuit, integrating flow (Integrated Flow), measuring the change in Integrated Flow (ΔV) over an INTERVAL extending from a selected point in the expiratory phase of a ventilator cycle to a selected point during the expiratory phase of a nearby ventilator cycle, repeating the measurement of ΔV for at least two said INTERVALs, processing PCIRCUIT to produce an index or indices that reflect(s) the pattern of pressure delivery by the ventilator during each of said INTERVALs, applying statistical methods to determine the relation between the differences in ΔV among 1NTERVALs and the corresponding differences in said index or indices of PCIRCUIT, and establishing from said relation the leak rate at specified PCIRCUIT values.
대표청구항
▼
1. A method for estimating gas leakage from the ventilator circuit and patient interface that relies on breath-by-breath or time-to-time variability in the pattern of pressure delivery by the ventilator, which comprises: generating signals that correspond to pressure (PCIRCUIT) and flow rate (Flow)
1. A method for estimating gas leakage from the ventilator circuit and patient interface that relies on breath-by-breath or time-to-time variability in the pattern of pressure delivery by the ventilator, which comprises: generating signals that correspond to pressure (PCIRCUIT) and flow rate (Flow) in the ventilator circuit,integrating Flow (Integrated Flow),measuring the change in Integrated Flow (ΔV) over an INTERVAL extending from a selected point in the expiratory phase of a ventilator cycle to a selected point during the expiratory phase of a nearby ventilator cycle,repeating said measurement of ΔV in at least two said INTERVALs,processing PCIRCUIT to produce an index or indices that reflect(s) the pattern of pressure delivery by the ventilator during each of said INTERVALs,applying statistical methods to determine the relation between the differences in ΔV among INTERVALs and the corresponding differences in said index or indices of PCIRCUIT, andestablishing from said relation the leak rate at specified PCIRCUIT values. 2. The method of claim 1 wherein selected points in the expiratory phase are the end-expiratory points. 3. The method of claim 1 wherein the selected points delimiting INTERVAL are chosen so that Flow is similar at the two sampling points. 4. The method of claim 3 wherein selected points delimiting INTERVAL are chosen so that both Flow and the rate of change in Flow are similar at the two sampling points. 5. The method of claim 1 wherein each ΔV is divided by the duration of the INTERVAL over which it was measured to obtain an average Flow rate over the INTERVAL (Average Flow). 6. The method of claim 1 wherein processing of PCIRCUIT to produce an index or indices that reflect(s) the pattern of pressure delivery by the ventilator comprises determination of times spent in different pressure ranges (Times) within each INTERVAL, said Times serving as the Indices of pressure pattern. 7. The method of claim 6 wherein said Times are divided by the duration of the INTERVAL to obtain the fraction of time spent in said pressure ranges (Time Fractions). 8. The method of claim 1 wherein processing of PCIRCUIT to produce an index or indices that reflect(s) the pattern of pressure delivery by the ventilator comprises calculating the time courses of a plurality of specified mathematical functions of PCIRCUIT within each INTERVAL and integrating the resulting values of processed PCIRCUIT over the period of the INTERVAL, thereby resulting in a plurality of indices of pressure pattern (Integrals) within each INTERVAL, with each Integral corresponding to pressure processing using a specified mathematical function. 9. The method of claim 8 wherein Integrals are divided by the corresponding duration of the INTERVALs to obtain the average Integral (Average Integrals). 10. The method of claim 1 wherein processing of PCIRCUIT to produce an index or indices that reflect(s) the pattern of pressure delivery by the ventilator comprises calculating the times spent at a common reference high pressure and a common reference low pressure. 11. The method of claim 1 wherein statistical methods comprise regression analyses of the results obtained from a plurality of INTERVALs, with AV or Average Flow of each INTERVAL serving as the dependent variable and the index of indices of PCIRCUIT in the same INTERVALs serving as the independent variable(s). 12. The method of claim 11 wherein additional independent variables that reflect contribution of true changes in lung volume to ΔV are incorporated in the regression. 13. The method of claim 1 wherein the results of the statistical analysis performed on a plurality of previous INTERVALs are applied to current pressure values to estimate current gas leakage. 14. The method of claim 1 including a method for estimating variability in pattern of pressure delivery. 15. The method of claim 1 including a method for detecting a change in the leak characteristics. 16. A device for estimating gas leakage from the ventilator circuit and patient interface that relies on breath-by-breath or time-to-time variability in the pattern of pressure delivery by the ventilator, which comprises: computer for storing and processing data corresponding to pressure (PCIRCUIT) and flow rate (Flow) in the ventilator circuit, with said processing comprising:algorithm(s) for integrating Flow (Integrated Flow),algorithm(s) for measuring the change in Integrated Flow (ΔV) over an INTERVAL extending from a selected point in the expiratory phase of a ventilator cycle to a selected point during the expiratory phase of a nearby ventilator cycle,repeating said measurement of ΔV in at least two said INTERVALs,algorithm(s) for processing PCIRCUIT to produce an index or indices that reflect(s) the pattern of pressure delivery by the ventilator during each of said INTERVALs,applying statistical methods to determine the relation between the differences in ΔV among INTERVALs and the corresponding differences in said index or indices of PCIRCUIT,establishing from said relation the leak rate at specified PCIRCUIT values. 17. The device of claim 16 wherein selected points in the expiratory phase are the end-expiratory points. 18. The device of claim 16 wherein the selected points delimiting INTERVAL are chosen so that Flow is similar at the two sampling points. 19. The device of claim 18 wherein selected points delimiting INTERVAL are chosen so that both Flow and the rate of change in Flow are similar at the two sampling points. 20. The device of claim 16 wherein each ΔV is divided by the duration of the INTERVAL over which it was measured to obtain an average Flow rate over the INTERVAL (Average Flow). 21. The device of claim 16 wherein processing of PCIRCUIT to produce an index or indices that reflect(s) the pattern of pressure delivery by the ventilator comprises determination of times spent in different pressure ranges (Times) within each INTERVAL, said Times serving as the Indices of pressure pattern. 22. The device of claim 21 wherein said Times are divided by the duration of the INTERVAL to obtain the fraction of time spent in said pressure ranges (Time Fractions). 23. The device of claim 16 wherein processing of PCIRCUIT to produce an index or indices that reflect(s) the pattern of pressure delivery by the ventilator comprises calculating the time courses of a plurality of specified mathematical functions of PCIRCUIT within each INTERVAL and integrating the resulting values of processed PCIRCUIT over the period of the INTERVAL, thereby resulting in a plurality of indices of pressure pattern (Integrals) within each INTERVAL, with each Integral corresponding to pressure processing using a specified mathematical function. 24. The device of claim 23 wherein Integrals are divided by the corresponding duration of the INTERVALs to obtain the average Integral (Average Integrals). 25. The device of claim 16 wherein processing of PCIRCUIT to produce an index or indices that reflect(s) the pattern of pressure delivery by the ventilator comprises calculating the times spent at a common reference high pressure and a common reference low pressure. 26. The device of claim 16 wherein statistical methods comprise regression analyses of the results obtained from a plurality of INTERVALs, with ΔV or Average Flow of each INTERVAL serving as the dependent variable and the index of indices of PCIRCUIT in the same INTERVALs serving as the independent variable(s). 27. The device of claim 26 wherein additional independent variables that reflect contribution of true changes in lung volume to ΔV are incorporated in the regression. 28. The device of claim 16 wherein the results of the statistical analysis performed on a plurality of previous INTERVALs are applied to current pressure values to estimate current gas leakage. 29. The device of claim 16 including algorithms for estimating variability in pattern of pressure delivery. 30. The device of claim 16 including algorithms for detecting a change in the leak characteristics. 31. A computer readable medium having a computer program stored thereon for estimating gas leakage from the ventilator circuit and patient interface that relies on breath-by-breath or time-to-time variability in the pattern of pressure delivery by the ventilator, the computer program comprising: program code for receiving signals that correspond to pressure (PCIRCUIT) and flow rate (Flow) in the ventilator circuit,program code for integrating Flow (Integrated Flow),program code for measuring the change in Integrated Flow (ΔV) over an INTERVAL extending from a selected point in the expiratory phase of a ventilator cycle to a selected point during the expiratory phase of a nearby ventilator cycle,program code for repeating said measurement of ΔV in at least two said INTERVALs,program code for, based on PCIRCUIT , producing an index or indices that reflect(s) the pattern of pressure delivery by the ventilator during each of said INTERVALs,program code for applying statistical methods to determine the relation between the differences in ΔV among INTERVALs and the corresponding differences in said index or indices of PCIRCUIT,program code for establishing from said relation the leak rate at specified PCIRCUIT values. 32. A system for estimating gas leakage from the ventilator circuit and patient interface that relies on breath-by-breath or time-to-time variability in the pattern of pressure delivery by the ventilator, the system comprising: a processing structure and a computer readable medium accessible by the processing structure for storing and processing data corresponding to pressure (PCIRCUIT) and flow rate (Flow) in the ventilator circuit, wherein the processing is performed by integrating Flow (Integrated Flow), measuring the change in Integrated Flow (ΔV) over an INTERVAL extending from a selected point in the expiratory phase of a ventilator cycle to a selected point during the expiratory phase of a nearby ventilator cycle, repeating said measurement of ΔV in at least two said INTERVALs, processing PCIRCUIT to produce an index or indices that reflect(s) the pattern of pressure delivery by the ventilator during each of said INTERVALs, applying statistical methods to determine the relation between the differences in ΔV among INTERVALS and the corresponding differences in said index or indices of PCIRCUIT, and establishing from said relation the leak rate at specified PCIRCUIT values.
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