Calcium preparation and method of production thereof
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A23L-001/304
A61K-031/19
A61K-033/06
A61K-009/00
A61K-033/42
A23L-002/52
출원번호
US-0629286
(2012-09-27)
등록번호
US-8911805
(2014-12-16)
우선권정보
JP-2010-083190 (2010-03-31)
발명자
/ 주소
Yoshida, Tsutomu
Yasuda, Toshitaka
Shimojoh, Manabu
Masaki, Kazuyoshi
출원인 / 주소
Toyo Suisan Kaisha, Ltd.
대리인 / 주소
Holtz, Holtz, Goodman & Chick PC
인용정보
피인용 횟수 :
0인용 특허 :
5
초록▼
A stable Ca preparation in solution form even at high concentration is provided. The aqueous preparation of Ca includes water, Ca, compounds of Formula I and Formula II. Most of Ca is in non-ionic form and forms a complex. In the complex, Ca binds to the compound(s) of Formula I and/or Formula II in
A stable Ca preparation in solution form even at high concentration is provided. The aqueous preparation of Ca includes water, Ca, compounds of Formula I and Formula II. Most of Ca is in non-ionic form and forms a complex. In the complex, Ca binds to the compound(s) of Formula I and/or Formula II in a state that basic structures of them are kept. At least partially, the complex forms colloidal particles. The aqueous preparation is transparent. pH is equal to or higher than that of slightly acid; A1, A2, A3, A4, A5 and A6 are independently O− or OX. X represents a monovalent or polyvalent cation.
대표청구항▼
1. An aqueous preparation of calcium comprising water, calcium, a compound of a Formula I, and a compound of a Formula II as constituent elements, wherein 98% or more of the calcium is in a non-ionic calcium form and forms a complex, wherein in the complex, the calcium binds to the compound of the F
1. An aqueous preparation of calcium comprising water, calcium, a compound of a Formula I, and a compound of a Formula II as constituent elements, wherein 98% or more of the calcium is in a non-ionic calcium form and forms a complex, wherein in the complex, the calcium binds to the compound of the Formula I and/or the compound of the Formula II in a state that basic structures of these compounds are kept, and at least a part of the complex forms colloidal particles having an average particle diameter of 100 nm or less, andwherein the aqueous preparation of calcium is a transparent aqueous preparation having a pH value ranging from 4 to 13; wherein, A1, A2, A3, A4, A5 and A6 are independently O— or OX, X represents a monovalent or polyvalent cation, and the Xs are the same or different when multiple OXs exist. 2. A solid preparation of calcium obtained by drying the aqueous preparation of calcium according to claim 1. 3. A solid preparation of calcium obtained by drying the aqueous preparation of calcium according to claim 1, wherein adding water again to the solid preparation provides the aqueous preparation of calcium according to claim 1. 4. An aqueous preparation of calcium comprising water, calcium, a compound of a Formula I, a compound of a Formula II, and fluorine as constituent elements, wherein 98% or more of the calcium is in a non-ionic calcium form and forms a complex, wherein in the complex, the calcium binds to the compound of the Formula I and/or the compound of the Formula II in a state that basic structures of these compounds are kept, at least a part of the fluorine binds to the complex, and at least a part of the complex forms colloidal particles having an average particle diameter of 100 nm or less, and wherein the aqueous preparation of calcium is a transparent aqueous preparation having a pH value ranging from 4 to 13; wherein, A1, A2, A3, A4, A5 and A6 are independently O— or OX, X represents a monovalent or polyvalent cation, and the Xs are the same or different when multiple OXs exist. 5. A solid preparation of calcium obtained by drying the aqueous preparation of calcium according to claim 4. 6. The solid preparation of calcium obtained by drying the aqueous preparation of calcium according to claim 4, wherein adding water again to the solid preparation provides the aqueous preparation of calcium according to claim 4. 7. A method of producing an aqueous preparation of calcium comprising: (a) mixing a calcium source ionized in water with a source of a compound of a Formula I and a source of a compound of a Formula II to form a non-colloidal liquid; and(b) aging said non-colloidal liquid from step (a) to convert said non-colloidal liquid to a colloidal liquid thereby converting from an opaque liquid to a transparent liquid under a condition where the pH of a final solution has a value ranging from 4 to 13; wherein, A1, A2, A3, A4, A5 and A6 are independently O— or OX, X represents a monovalent or polyvalent cation, and the Xs are the same or different when multiple OXs exist. 8. A method of producing an aqueous preparation of calcium comprising: (1) ionizing a calcium source in water;(2) mixing the calcium ionized in step (1) with a source of a compound of a Formula I and a source of a compound of a Formula II to form a non-colloidal liquid;(3) aging said non-colloidal liquid obtained in step (2) to convert said non-colloidal liquid to a colloidal liquid thereby converting from an opaque liquid to a transparent liquid; and(4) adjusting the pH so that a solution finally obtained in any of steps (1) to (3) has a pH value ranging from 4 to 13; wherein, A1, A2, A3, A4, A5 and A6 are independently O— or OX, X represents a monovalent or polyvalent cation, and the Xs are the same or different when multiple OXs exist. 9. A method of producing an aqueous preparation of calcium comprising: (a) mixing a calcium source ionized in water with a source of a compound of a Formula I, a source of a compound of a Formula II, and a fluorine source to form a non-colloidal liquid; and(b) aging said non-colloidal liquid obtained from step (a) to convert said non-colloidal liquid to a colloidal liquid thereby converting from an opaque liquid to a transparent liquid under a condition where the pH of a final solution has a value ranging from 4 to 13; wherein, A1, A2, A3, A4, A5 and A6 are independently O— or OX, X represents a monovalent or polyvalent cation, and the Xs are the same or different when multiple OXs exist. 10. A method of producing an aqueous preparation of calcium comprising: (1) ionizing a calcium source in water;(2) mixing the calcium ionized in step (1) with a source of a compound of a Formula I, a source of a compound of a Formula II, and a fluorine source to form a non-colloidal liquid;(3) aging said non-colloidal liquid obtained in step (2) to convert said non-colloidal liquid to a colloidal liquid thereby converting from an opaque liquid to a transparent liquid; and(4) adjusting the pH so that a solution finally obtained in any of steps (1) to (3) has a pH value ranging from 4 to 13; wherein, A1, A2, A3, A4, A5 and A6 are independently O— or OX, X represents a monovalent or polyvalent cation, and the Xs are the same or different when multiple OXs exist. 11. A method of producing a solid preparation of calcium comprising: further drying the aqueous preparation of calcium obtained by the method according to any one of claims 7 to 10. 12. An aqueous preparation of calcium comprising water, calcium, a compound of a Formula I, and a compound of a Formula II as constituent elements, which is produced by a method comprising: (a) mixing a calcium source ionized in water with a source of a compound of the Formula I and a source of a compound of the Formula II to form a non-colloidal liquid; and(b) aging said non-colloidal liquid from step (a) to convert to a colloidal liquid by converting said non-colloidal liquid from an opaque liquid to a transparent liquid under a condition where the pH has a value ranging from 4 to 13;wherein 98% or more of the calcium is in a non-ionic calcium form and forms a complex, wherein in the complex, the calcium binds to the compound of the Formula I and/or the compound of the Formula II in a state that basic structures of these compounds are kept, and at least a part of the complex forms colloidal particles having an average particle diameter of 100 nm or less, andwherein the aqueous preparation of calcium is a transparent aqueous preparation having a pH value ranging from 4 to 13; wherein, A1, A2, A3, A4, A5 and A6 are independently O— or OX, X represents a monovalent or polyvalent cation, and the Xs are the same or different when multiple OXs exist. 13. An aqueous preparation of calcium comprising water, calcium, a compound of a Formula 1, and a compound of a Formula II as constituent elements, which is produced by a method comprising: (1) ionizing a calcium source in water;(2) mixing the calcium ionized in step (1) with a source of a compound of the Formula I and a source of a compound of the Formula II to form a non-colloidal liquid;(3) aging said non-colloidal liquid obtained in step (2) to convert said non-colloidal liquid to a colloidal liquid thereby converting from an opaque liquid to a transparent liquid; and(4) adjusting the pH so that a solution finally obtained in any of steps (1) to (3) has a pH value ranging from 4 to 13;wherein 98% or more of the calcium is in a non-ionic calcium form and forms a complex, wherein in the complex, the calcium binds to the compound of the Formula I and/or the compound of the Formula II in a state that basic structures of these compounds are kept, and at least a part of the complex forms colloidal particles having an average particle diameter of 100 nm or less, and wherein the aqueous preparation of calcium is a transparent aqueous preparation having a pH value ranging from 4 to 13; wherein, A1, A2, A3, A4, A5 and A6 are independently O— or OX, X represents a monovalent or polyvalent cation, and the Xs are the same or different when multiple OXs exist. 14. An aqueous preparation of calcium comprising water, calcium, a compound of a Formula I, a compound of a Formula II, and fluorine constituent elements, which is produced by a method comprising: (a) mixing a calcium source ionized in water with a source of a compound of the Formula I, a source of a compound of the Formula II, and a fluorine source to form a non-colloidal liquid; and(b) aging said non-colloidal liquid obtained in step (a) to convert said non-colloidal liquid to a colloidal liquid thereby converting from an opaque liquid to a transparent liquid under a condition where the pH of a final solution has a value ranging from 4 to 13;wherein 98% or more of the calcium is in a non-ionic calcium form and forms a complex, wherein in the complex, the calcium binds to the compound of the Formula I in a state that basic structures of these compounds are kept, at least a part of the fluorine binds to the complex, and at least a part of the complex forms colloidal particles having an average particle diameter of 100 nm or less, and,wherein the aqueous preparation of calcium is a transparent aqueous preparation of calcium having a pH value ranging from 4 to 13; wherein, A1, A2, A3, A4, A5 and A6 are independently O— or OX, X represents a monovalent or polyvalent cation, and the Xs are the same or different when multiple OXs exist. 15. An aqueous preparation of calcium comprising water, calcium, a compound of a Formula I, a compound of a Formula II, and fluorine as constituent elements, which is produced by a method comprising: (1) ionizing a calcium source in water;(2) mixing the calcium ionized in step (1) with a source of a compound of the Formula I, a source of a compound of the Formula II, and a fluorine source to form a a non-colloidal liquid;(3) aging said non-colloidal liquid obtained in step (2) to convert said non-colloidal liquid to a colloidal liquid thereby converting from an opaque liquid to a transparent liquid; and(4) adjusting the pH so that a solution finally obtained in any of steps (1) to (3) has a pH value ranging from 4 to 13;wherein 98% or more of the calcium is in a non-ionic calcium form and forms a complex, wherein in the complex, the calcium binds to the compound of the Formula I and/or the compound of the Formula II in a state that basic structures of these compounds are kept, at least a part of the fluorine binds to the complex, and at least a part of the complex forms colloidal particles having an average particle diameter of 100 nm or less, andwherein the aqueous preparation of calcium is a transparent aqueous preparation having a pH value ranging from 4 to 13; wherein, A1, A2, A3, A4, A5 and A6 are independently O— or OX, X represents a monovalent or polyvalent cation, and the Xs are the same or different when multiple OXs exist. 16. The aqueous preparation of calcium according to claim 12 or 14, wherein the aqueous preparation of calcium of claim maintains and contains all the constituents present in the reaction. 17. The aqueous preparation of calcium according to claim 13 or 15, wherein the aqueous preparation of calcium maintains and contains all the constituents present in steps (1) and (2). 18. A solid preparation of calcium produced by the method according to claim 11. 19. A solid preparation of calcium produced by drying the aqueous preparation of calcium obtained by the method according to claims 7 or 8, wherein adding water to the solid preparation leads to an aqueous preparation of calcium comprising water, calcium, a compound of a Formula I, and a compound of a Formula II as constituent elements, wherein 98% or more of the calcium is in a non-ionic calcium form and forms a complex, wherein in the complex, the calcium binds to the compound of the Formula I and/or the compound of the Formula II in a state that basic structures of these compounds are kept, and at least a part of the complex forms colloidal particles having an average particle diameter of 100 nm or less, andwherein the aqueous preparation of calcium is a transparent aqueous preparation having a pH value ranging from 4 to 13; wherein, A1, A2, A3, A4, A5 and A6 are independently O— or OX, X represents a monovalent or polyvalent cation, and the Xs are the same or different when multiple OXs exist. 20. A method of preventing the formation of precipitates derived from calcium in a calcium solution comprising: (a) mixing calcium ionized in water with a compound of a Formula I and a compound of a Formula II to form a non-colloidal liquid; and(b) aging to convert said non-colloidal liquid to a colloidal liquid thereby converting from an opaque liquid to a transparent liquid under a condition where the pH of a final solution has a value ranging from 4 to 13; wherein, A1, A2, A3, A4, A5 and A6 are independently O— or OX, X represents a monovalent or polyvalent cation, and the Xs are the same or different when multiple OXs exist. 21. A method of preventing the formation of precipitates derived from calcium in a calcium solution comprising: (1) ionizing calcium in water;(2) mixing the calcium ionized in (1) with a Compound of a Formula I and a compound of a Formula II to form a non-colloidal liquid;(3) aging said non-colloidal liquid obtained in step (2) to convert said non-colloidal liquid to a colloidal liquid thereby converting from an opaque liquid to a transparent liquid; and(4) adjusting the pH so that a solution finally obtained in any of steps (1) to (3) has a pH value ranging from 4 to 13; wherein, A1, A2, A3, A4, A5 and A6 are independently O— or OX, X represents a monovalent or polyvalent cation, and the Xs are the same or different when multiple OXs exist. 22. A solid preparation of calcium produced by drying the aqueous preparation of calcium obtained by the method according to claims 9 or 10, wherein adding water to the solid preparation leads to an aqueous preparation of calcium comprising water, calcium, a compound of a Formula I, a compound of a Formula II, and fluorine as constituent elements,wherein 98% or more of the calcium is in a non-ionic calcium form and forms a complex, wherein in the complex, the calcium binds to the compound of the Formula I and/or the compound of the Formula II in a state that basic structures of these compounds are kept, at least a part of the fluorine binds to the complex, and at least a part of the complex forms colloidal particles having an average particle diameter of 100 nm or less, and wherein the aqueous preparation of calcium is a transparent aqueous preparation having a pH value ranging from 4 to 13; wherein, A1, A2, A3, A4, A5 and A6 are independently O— or OX, X represents a monovalent or polyvalent cation, and the Xs are the same or different when multiple OXs exist.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (5)
Nakel Gunther M. (Aurora IN) Russell Wendy E. (Fairfield OH) Dake Timothy W. (Cincinnati OH) Heckert David C. (Oxford OH), Beverages and beverage concentrates nutritionally supplemented with calcium.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.