초록 ▼

The invention provides a topical formulation adapted for treatment of a skin condition comprising (i) at least one retinoid; and (ii) salicylic acid or an ester, amide, salt, or solvate thereof. The invention also includes a kit for treatment of skin conditions comprising a retinoid and salicylic ac

The invention provides a topical formulation adapted for treatment of a skin condition comprising (i) at least one retinoid; and (ii) salicylic acid or an ester, amide, salt, or solvate thereof. The invention also includes a kit for treatment of skin conditions comprising a retinoid and salicylic acid, as well as a method of treating skin conditions utilizing the inventive formulation and kit.

대표청구항 ▼

1. A method for treating a skin condition selected from the group consisting of acne vulgaris, cystic acne, hyper-pigmentation, dermal hypoplasia, epidermal hypoplasia, dermal keratosis, epidermal keratoses, wrinkles of the skin as an incident of aging, enlarged pores, surface roughness, ichthyoses,

1. A method for treating a skin condition selected from the group consisting of acne vulgaris, cystic acne, hyper-pigmentation, dermal hypoplasia, epidermal hypoplasia, dermal keratosis, epidermal keratoses, wrinkles of the skin as an incident of aging, enlarged pores, surface roughness, ichthyoses, follicular disorders, benign epithelial tumors, perforated dermatoses, disorders of keratinization, and combinations thereof, comprising topically applying to skin affected by the skin condition a composition comprising: (i) at least one active agent according to the structure of Formula (I) or Formula (II) wherein R is: X is —H, —F, —Cl, —Br, —I, —OH, —OR, —OR′,  —NO2, —NH2, —NHR′, or —NR′2;n is a number from 1 to 5;R′ is H or any of the lower alkyls ranging from C1 to C6;wherein R″ is  or R′;R′″ is the hydrocarbon backbone of fatty acids;R″″ is R′ or the hydrocarbon backbone of fatty acids;R′″″ is the lower alkyls ranging from C1 to C6; and further,where there are two or more R′, R″, R′″, R″″, or R′″″ groups attached to the same carbon, each R′, R″, R′″, R″″, or R′″″ group may be the same as or different from the other R′, R″, R′″, R″, or R′″ groups attached to that carbon;(ii) an active agent according to the structure of Formula (VIII) or a salt thereof; and (iii) isohexadecane, polysorbate, phenoxyethanol, one or more C12-C16 alcohols, and one or more polyols. 2. The method according to claim 1, wherein the one or more C12-C16 alcohols comprises cetyl alcohol. 3. The method according to claim 1, wherein the one or more polyols comprises one or both of glycerin and ethoxydiglycol. 4. The method according to claim 1, wherein the composition further comprises one or both of polyethylene glycol (PEG) and xanthan gum. 5. The method according to claim 1, further comprising co-administering a second, different composition that comprises at least one active agent according to the structure of Formula (I) or Formula (II) wherein R is: X is —H, —F, —Cl, —Br, —I, —OH, —OR, —OR′,  —NO2, —NH2, —NHR′, or —NR′2;n is a number from 1 to 5;R′ is H or any of the lower alkyls ranging from C1 to C6;wherein R″ is  or R′;R′″ is the hydrocarbon backbone of fatty acids;R″″ is R′ or the hydrocarbon backbone of fatty acids;R′″″ is the lower alkyls ranging from C1 to C6; and further,where there are two or more R′, R″, R″″, R″″, or R′″″ groups attached to the same carbon, each R′, R″, R′″, R″″, or R′″″ group may be the same as or different from the other R′, R″, R′″, R″″, or R′″″ groups attached to that carbon. 6. The method according to claim 5, wherein said co-administration comprises sequential administration in any order. 7. The method according to claim 5, wherein the second composition comprises a cleanser. 8. The method according to claim 5, wherein the second composition comprises a moisturizer. 9. A composition adapted for topical administration to the skin, the composition comprising: (i) one or more of: 13-trans retinoic 1-hydroxy-3,3-dimethyl-2-butanone ester; 2-(13-cis-retinoyloxy)-4′-methoxyacetophenone; and pinacoyl 9-cis-retinoate;(ii) an active agent according to the structure of Formula (VIII) or a salt thereof;(iii) one or more C12-C16 alcohols;(iv) one or more polyols;(v) a polysorbate; and(vi) one or more of isohexadecane, polyoxyethanol, polyethylene glycol (PEG), and xanthan gum. 10. The composition according to claim 9, wherein the one or more C12-C16 alcohols comprises cetyl alcohol. 11. The composition according to claim 9, wherein the one or more polyols comprises one or both of glycerin and ethoxydiglycol. 12. A kit comprising at least two containers that separately include different compositions adapted for topical administration, wherein: (i) one of the at least two containers includes a composition according to claim 9;(ii) one of the at least two containers includes a composition that comprises a cleanser or a moisturizer; and(iii) the kit includes a set of instructions containing dosage and administration information instructing a user regarding sequential administration of the different compositions in the at least two containers.