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다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0921104 (2013-06-18) |
등록번호 | US-8912193 (2014-12-16) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 1 인용 특허 : 423 |
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for
A breath-powered, dry powder inhaler, a cartridge, and a pulmonary drug delivery system are provided. The dry powder inhaler can be provided with or without a unit dose cartridge for using with the inhaler. The inhaler and/or cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of diabetes and/or obesity. The dry powder inhaler is compact; can be provided in various shapes and sizes, colors, and comprises a housing, a mouthpiece, a cartridge placement area, and a mechanism for opening and closing the medicament cartridge. The device is easy to manufacture, provides a pre-metered single unit dose, it is relatively easy to use, and can be reusable or disposable.
1. Fumaryl diketopiperazine (FDKP) microparticles comprising a trans-FDKP isomer content of about 45% to about 63%. 2. The FDKP microparticles of claim 1 having a trans-FDKP isomer content of about 52% to about 63%. 3. The FDKP microparticles of claim 1 having a trans-FDKP isomer content of about 50
1. Fumaryl diketopiperazine (FDKP) microparticles comprising a trans-FDKP isomer content of about 45% to about 63%. 2. The FDKP microparticles of claim 1 having a trans-FDKP isomer content of about 52% to about 63%. 3. The FDKP microparticles of claim 1 having a trans-FDKP isomer content of about 50% to about 56%. 4. The FDKP microparticles of claim 1 having a trans-FDKP isomer content of about 54% to about 56%. 5. The FDKP microparticles of claim 1 wherein the FDKP microparticles comprise a drug. 6. The FDKP microparticles of claim 5 having a trans-FDKP isomer content of about 50% to about 56%. 7. The FDKP microparticles of claim 5 wherein the drug is insulin. 8. The microparticles of claim 7 wherein the insulin content is about 3 to about 4 U/mg. 9. A dry powder comprising the microparticles of claim 1. 10. The dry powder of claim 9, wherein the microparticles have a trans-FDKP isomer content of about 53% to about 63%. 11. A method of treating diabetes comprising administering the microparticles of claim 7 to a person in need thereof. 12. FDKP microparticles having improved aerodynamic performance that have been prepared by a process comprising: determining the trans-FDKP isomer content;wherein the microparticles have a trans-FDKP isomer content of about 45% to about 65%. 13. The FDKP microparticles of claim 12 having a trans-FDKP isomer content of about 50% to about 63%. 14. The FDKP microparticles of claim 12 having a trans-FDKP isomer content of about 54% to about 56%. 15. An FDKP composition comprising a trans isomer content of about 45% to about 56%. 16. Microparticles comprising the FDKP composition of claim 15. 17. The FDKP microparticles of claim 16, wherein the trans-FDKP content of the microparticles is about 45% to about 54%. 18. The FDKP microparticles of claim 16 having a trans-FDKP isomer content of about 50% to about 56%. 19. The FDKP microparticles of claim 16 having a trans-FDKP isomer content of about 53% to about 56%. 20. The FDKP microparticles of claim 5 having a manufacturing specification in a range of about 53% to about 63% trans-FDKP isomer content, based upon the total content of FDKP. 21. The method of claim 11 wherein said microparticles are administered using an inhalation system for delivering a dry powder medicament to a pulmonary tract, comprising a dry powder inhaler configured to have at least two inlet apertures, wherein a first inlet aperture is in communication with a first air flow pathway and a second inlet aperture is in communication with a second air flow pathway, and the first airflow pathway and the second airflow pathway converge in a substantially perpendicular manner during an inhalation maneuver, and wherein said inhalation system has a total resistance to flow in a dosing configuration ranging in value from 0.065 to about 0.200 (IkPa)/liter per minute.
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