Gas pressure actuated microneedle arrays, and systems and methods relating to same
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-037/00
A61L-031/16
출원번호
US-0252739
(2002-09-23)
등록번호
US-8920375
(2014-12-30)
발명자
/ 주소
Gonnelli, Robert R.
출원인 / 주소
Valeritas, Inc.
대리인 / 주소
Warren, Esq., Lisa M.
인용정보
피인용 횟수 :
12인용 특허 :
64
초록
The microneedle devices disclosed herein in some embodiments include a substrate; one or more microneedles; a reservoir for delivery of drugs; a gas source, and, optionally, pump(s), sensor(s), and/or microprocessor(s) to control the interaction of the foregoing.
대표청구항▼
1. A microneedle device, comprising: a substrate,a microneedle array attached to or integrally formed on a base of the substrate,a fluid reservoir,a gas source, anda flexible layer which allows one or more substances from the fluid reservoir and gas from the gas source to pass therethrough,wherein s
1. A microneedle device, comprising: a substrate,a microneedle array attached to or integrally formed on a base of the substrate,a fluid reservoir,a gas source, anda flexible layer which allows one or more substances from the fluid reservoir and gas from the gas source to pass therethrough,wherein said fluid reservoir is disposed between said gas source and said flexible layer and wherein activation of the gas source causes gas to flow into the fluid reservoir and forces a substance from the fluid reservoir, through the flexible layer, and through the microneedles of the microneedle array. 2. The device of claim 1, wherein the fluid reservoir contains a fluid. 3. The device of claim 2, wherein the fluid includes a therapeutic agent. 4. The device of claim 3, wherein the therapeutic agent is selected from vaccines, chemotherapy agents, pain relief agents, dialysis-related agents, blood thinning agents, and compounds that can be targeted to carry compounds that can kill cancer cells. 5. The device of claim 3, wherein the therapeutic agent is selected from proteins, enzymes, polysaccharides, polynucleotide molecules, and synthetic organic and inorganic compounds. 6. The device of claim 3, wherein the therapeutic agent is selected from anti-infectives, hormones, growth regulators, drugs regulating cardiac action or blood flow, and drugs for pain control. 7. The device of claim 3, wherein the therapeutic agent is selected from insulin, heparin, morphine, interferon, EPO, tumor vaccines, and infectious disease vaccines. 8. The device of claim 3, wherein the therapeutic agent is insulin. 9. The device of claim 1, wherein the flexible layer is resilient or elastic. 10. The device of claim 1, wherein the flexible layer has slits. 11. The device of claim 1, wherein the flexible layer has one-way valves. 12. The device of claim 1, wherein the flexible layer is semi-permeable. 13. The device of claim 1, wherein the flexible layer substantially prevents one or more substances from passing therethrough. 14. The device of claim 1, wherein the flexible layer is a material selected from the group consisting of a rubber, a polymer, a plastic, a metal, and a composite. 15. The device of claim 1, wherein the device is skin patch. 16. The device of claim 1, further comprising a chamber disposed between said flexible layer and said substrate. 17. A method for delivering a drug through a microneedle device, comprising providing a substrate,providing a microneedle array attached to or integrally formed on a base of the substrate,providing a gas source,providing a fluid reservoir comprising drug to be delivered,providing a flexible layer which allows drug from the fluid reservoir and gas from the gas source to pass therethrough, wherein the reservoir is disposed between the gas source and the flexible layer, and wherein activation of the gas source causes gas to flow into the fluid reservoir and forces drug from the fluid reservoir, through the flexible layer, and through the microneedle array, andactivating the gas source to deliver drug. 18. The method of claim 17, further comprising providing a chamber disposed between said flexible layer and said substrate. 19. The device of claim 1, wherein the microneedle array comprises hollow microneedles. 20. The device of claim 1, wherein the microneedle array comprises porous microneedles. 21. The method of claim 17, wherein the microneedle array comprises hollow microneedles. 22. The method of claim 17, wherein the microneedle array comprises porous microneedles.
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