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다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
NTIS 바로가기다음과 같은 기능을 한번의 로그인으로 사용 할 수 있습니다.
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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0425791 (2009-04-17) |
등록번호 | US-8920491 (2014-12-30) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 1 인용 특허 : 474 |
In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing
In one aspect, a medical device has a first configuration and a second configuration, a reservoir containing a therapeutic agent, and a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material. In another aspect, a medical device has a reservoir containing a therapeutic agent, a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material, and a swellable material disposed between the barrier layer and a surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment. In yet another aspect, a medical device has a multi-layered coating having alternating reservoir layers and barrier layers, and a plurality of excavated regions penetrating through at least a partial thickness of the multi-layered coating. In yet another aspect, a medical device has a polymer layer comprising a block co-polymer, wherein the polymer layer contains a therapeutic agent, and a barrier layer disposed over the polymer layer, wherein the barrier layer comprises an inorganic material, and wherein the barrier layer has a plurality of discontinuities. Methods of forming coatings on medical devices and methods of delivering therapeutic agents to body sites are also disclosed.
1. A medical device comprising: a reservoir on a surface of a medical device, the reservoir containing a therapeutic agent;a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material; anda swellable material disposed between the barrier layer and the surfac
1. A medical device comprising: a reservoir on a surface of a medical device, the reservoir containing a therapeutic agent;a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material; anda swellable material disposed between the barrier layer and the surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment,wherein the barrier layer has a first permeability to the therapeutic agent prior to swelling of the swellable material and a second permeability to the therapeutic agent after swelling of the swellable material, and wherein the second permeability is greater than the first permeability, wherein the first permeability is provided by one or more discontinuities in the barrier layer. 2. A medical device comprising: a reservoir on a surface of a medical device, the reservoir containing a therapeutic agent;a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material; anda swellable material disposed between the barrier layer and the surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment,wherein the barrier layer has a first permeability to the therapeutic agent prior to swelling of the swellable material, the first permeability being provided by one or more discontinuities in the barrier layer, and a second permeability to the therapeutic agent after swelling of the swellable material, wherein the second permeability is greater than the first permeability, and the swelling of the swellable material causes the formation of further discontinuities in the barrier layer. 3. The medical device of claim 2, wherein the medical device further comprises an intermediate layer disposed between the medical device and the barrier layer, wherein the intermediate layer comprises a polymeric material. 4. The medical device of claim 3, wherein the intermediate layer contains the reservoir containing the therapeutic agent. 5. The medical device of claim 4, wherein the medical device further comprises a swellable layer disposed between the medical device and the barrier layer, and wherein the swellable layer contains the swellable material. 6. The medical device of claim 4, wherein the intermediate layer further comprises the swellable material. 7. The medical device of claim 6, wherein the swellable material is contained in capsules. 8. The medical device of claim 2, wherein the barrier layer has a plurality of regions of structural weakness. 9. The medical device of claim 2, wherein the swellable material is a water-swellable polymer. 10. The medical device of claim 2, wherein the swellable material is an oxidizable metal that swells upon oxidation. 11. The medical device of claim 2, wherein the one or more discontinuities are created by cooling the barrier layer. 12. The medical device of claim 11, wherein the barrier layer is cooled by exposure to a cryogenic liquid. 13. The medical device of claim 2, wherein the one or more discontinuities are created by at least one cycle of heating and then cooling the barrier layer, or at least one cycle of cooling and then heating the barrier layer. 14. The medical device of claim 2, wherein the medical device is a balloon. 15. A stent comprising: a reservoir on a surface of a medical device, the reservoir containing a therapeutic agent;a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material; anda swellable material disposed between the barrier layer and the surface of the medical device, wherein the swellable material is a material that swells upon exposure to an aqueous environment,wherein the barrier layer has a first permeability to the therapeutic agent prior to swelling of the swellable material and a second permeability to the therapeutic agent after swelling of the swellable material, and wherein the second permeability is greater than the first permeability, wherein the first permeability is provided by one or more discontinuities in the barrier layer. 16. The stent of claim 15, wherein the swelling of the swellable material causes the formation of further discontinuities in the barrier layer. 17. The stent of claim 15, wherein the stent further comprises an intermediate layer disposed between the medical device and the barrier layer, wherein the intermediate layer comprises a polymeric material. 18. The stent of claim 17, wherein the intermediate layer contains the reservoir containing the therapeutic agent. 19. The stent of claim 17, wherein the medical device further comprises a swellable layer disposed between the stent and the barrier layer, and wherein the swellable layer contains the swellable material. 20. The stent of claim 17, wherein the intermediate layer further comprises the swellable material. 21. The stent of claim 20 wherein the swellable material is contained in capsules. 22. The stent of claim 15, wherein the barrier layer has a plurality of regions of structural weakness. 23. The stent of claim 15, wherein the swellable material is a water-swellable polymer. 24. The stent of claim 15, wherein the swellable material is an oxidizable metal that swells upon oxidation. 25. The stent of claim 15, wherein the one or more discontinuities are created by cooling the barrier layer. 26. The stent of claim 25, wherein the barrier layer is cooled by exposure to a cryogenic liquid. 27. The stent of claim 15, wherein the one or more discontinuities are created by at least one cycle of heating and then cooling the barrier layer, or at least one cycle of cooling and then heating the barrier layer. 28. A stent comprising: a reservoir on a surface of a stent, the reservoir containing a therapeutic agent;a barrier layer disposed over the reservoir, wherein the barrier layer comprises an inorganic material; anda swellable material disposed between the barrier layer and the surface of the stent, wherein the swellable material is a material that swells upon exposure to an aqueous environment,wherein the barrier layer has a first permeability to the therapeutic agent prior to swelling of the swellable material, the first permeability being provided by one or more discontinuities in the barrier layer, and a second permeability to the therapeutic agent after swelling of the swellable material, wherein the second permeability is greater than the first permeability, and the swelling of the swellable material causes the formation of further discontinuities in the barrier layer. 29. The stent of claim 28, wherein the stent further comprises an intermediate layer disposed between the stent and the barrier layer, wherein the intermediate layer comprises a polymeric material. 30. The stent of claim 29, wherein the intermediate layer contains the reservoir containing the therapeutic agent. 31. The stent of claim 30, wherein the stent further comprises a swellable layer disposed between the stent and the barrier layer, and wherein the swellable layer contains the swellable material. 32. The stent of claim 30, wherein the intermediate layer further comprises the swellable material. 33. The stent of claim 32, wherein the swellable material is contained in capsules. 34. The stent of claim 28, wherein the barrier layer has a plurality of regions of structural weakness. 35. The stent of claim 28, wherein the swellable material is a water-swellable polymer. 36. The stent of claim 28, wherein the swellable material is an oxidizable metal that swells upon oxidation. 37. The medical device of claim 28, wherein the one or more discontinuities are created by cooling the barrier layer. 38. The stent of claim 37, wherein the barrier layer is cooled by exposure to a cryogenic liquid. 39. The stent of claim 28, wherein the one or more discontinuities are created by at least one cycle of heating and then cooling the barrier layer, or at least one cycle of cooling and then heating the barrier layer. 40. The medical device of claim 1, wherein the swelling of the swellable material causes the formation of further discontinuities in the barrier layer.
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