A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and remo
A graft prostheses (11), materials and method for implanting, transplanting, replacing, or repairing a part of a patient. The graft prosthesis includes a purified, collagen-based matrix structure removed from a submucosa tissue source. The submucosa tissue source is purified by disinfection and removal steps to deactivate and remove contaminants, thereby making the purified structure biocompatible and suitable for grafting on and/or in a patient.
대표청구항▼
1. A surgical method for treating a patient, comprising: implanting a multilayer construct in the patient, the multilayer construct including a plurality of layers of tissue matrix material obtained from mammalian urinary tract tissue, wherein each of the layers of tissue matrix material includes su
1. A surgical method for treating a patient, comprising: implanting a multilayer construct in the patient, the multilayer construct including a plurality of layers of tissue matrix material obtained from mammalian urinary tract tissue, wherein each of the layers of tissue matrix material includes submucosa tissue and lamina propria tissue and retains one or more native growth factors in the tissue matrix material, wherein said tissue matrix material is provided in a sterile condition while retaining said one or more native growth factors, and wherein said one or more native growth factors includes Fibroblast Growth Factor-2; and wherein the tissue matrix material additionally retains at least one native bioactive agent selected from the group consisting of a proteoglycan, a glycoprotein, and a glycosaminoglycan. 2. The surgical method of claim 1, wherein said implanting includes applying the multilayer construct to a tissue wall in the body. 3. The surgical method of claim 2, wherein said tissue wall is an abdominal wall. 4. The surgical method of claim 1, wherein said implanting includes applying the multilayer construct to herniated tissue. 5. The surgical method of claim 1, wherein said implanting includes applying the multilayer construct to dermal tissue. 6. The surgical method of claim 1, wherein said implanting includes applying the multilayer construct to urogenital tissue. 7. The surgical method of claim 6, wherein the urogenital tissue is urinary bladder tissue. 8. The surgical method of claim 1, wherein said implanting includes applying the multilayer construct to neurologic tissue. 9. The surgical method of claim 8, wherein the neurologic tissue is dural tissue. 10. The surgical method of claim 1, wherein the tissue matrix material is obtained from a porcine tissue source. 11. The surgical method of claim 1, wherein the tissue matrix material, upon implantation in the patient, promotes regrowth of damaged tissue structures. 12. The surgical method of claim 1, wherein the tissue matrix material additionally retains a proteoglycan, a glycoprotein, and a glycosaminoglycan from the urinary tract tissue. 13. The surgical method of claim 1, wherein the tissue matrix material is remodelable. 14. The surgical method of claim 1, wherein the tissue matrix material has a bioburden level of less than 0.5 colony forming units per gram, a nucleic acid content level of less than 2 micrograms per milligram, a virus level of less than 5 plaque forming unit per gram, and a fungus level of less than 0.5 colony forming units per gram. 15. The surgical method of claim 14, wherein the tissue matrix material has not been treated with a chemical crosslinking agent. 16. The surgical method of claim 1, wherein the tissue matrix material has been sterilized through contact with an aqueous solution containing a peracid. 17. The surgical method of claim 16, wherein the peracid is peracetic acid. 18. The surgical method of claim 1, wherein the tissue matrix material has not been treated with a crosslinking agent. 19. The surgical method of claim 1, wherein the multilayer construct includes a first layer of tissue matrix material fused to a second layer of tissue matrix material. 20. The surgical method of claim 19, wherein the first layer of tissue matrix material has been fused to the second layer of tissue matrix material by compressing overlapping areas of the first layer of tissue matrix material and the second layer of tissue matrix material under dehydrating conditions. 21. A surgical method to repair a tissue structure of a patient, comprising: implanting a multilayer construct in the body of a patient and in contact with a tissue structure in need of repair, the multilayer construct including a plurality of layers of tissue matrix material obtained from mammalian urinary tract tissue, wherein each of the layers of tissue matrix material includes submucosa tissue and lamina propria tissue, wherein the submucosa tissue has been separated from attached tunica muscularis tissue occurring to the abluminal side of the submucosa tissue in the urinary tract tissue, and wherein the tissue matrix material retains a proteoglycan, a growth factor, a glycoprotein, and a glycosaminoglycan; and, wherein said implanting includes applying the multilayer construct to a tissue wall in the body. 22. The surgical method of claim 21, wherein the tissue matrix material retains Fibroblast Growth Factor-2. 23. A surgical method to repair a tissue structure of a patient, comprising: implanting a multilayer construct in the body of a patient and in contact with a tissue structure in need of repair, the multilayer construct including a plurality of layers of tissue matrix material obtained from mammalian urinary tract tissue, wherein each of the layers of tissue matrix material includes tissue material from at least a submucosa layer and a lamina propria layer of the urinary tract tissue, the tissue matrix material retaining one or more native growth factors in the tissue matrix material, wherein said tissue matrix material is provided in a sterile condition while retaining said one or more native growth factors, and wherein said one or more native growth factors includes Fibroblast Growth Factor-2; and wherein the tissue matrix material has not been treated with a chemical crosslinking agent. 24. The surgical method of claim 23, wherein the tissue matrix material additionally retains at least one native bioactive agent selected from the group consisting of a proteoglycan, a glycoprotein, and a glycosaminoglycan. 25. The surgical method of claim 23, wherein the tissue matrix material additionally retains a proteoglycan, a glycoprotein, and a glycosaminoglycan from the urinary tract tissue.
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이 특허에 인용된 특허 (111)
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