In one aspect, the invention relates to hydrolysis-resistant silicone compounds. In particular, disclosed are sterically hindered hydrolysis-resistant silicone compounds and improved purity hydrolysis-resistant silicone compounds. Also disclosed are processes for making hydrolysis-resistant silicone
In one aspect, the invention relates to hydrolysis-resistant silicone compounds. In particular, disclosed are sterically hindered hydrolysis-resistant silicone compounds and improved purity hydrolysis-resistant silicone compounds. Also disclosed are processes for making hydrolysis-resistant silicone compounds; the products of the disclosed processes; compositions and polymers comprising the disclosed compounds and products of the disclosed processes; and ophthalmic lenses, for example contact lenses, intraocular lenses, artificial cornea, and spectacle lenses, comprising the disclosed compositions, disclosed polymers, disclosed compounds, and products of the disclosed processes. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
대표청구항▼
1. An ophthalmic lens comprising a polymer comprising at least one residue of a compound having the structure: wherein M represents a radical-polymerizable group; wherein M is an acryloyloxy group or a methacryloyloxy group;wherein L represents an optionally substituted divalent C1-C20 organic group
1. An ophthalmic lens comprising a polymer comprising at least one residue of a compound having the structure: wherein M represents a radical-polymerizable group; wherein M is an acryloyloxy group or a methacryloyloxy group;wherein L represents an optionally substituted divalent C1-C20 organic group substituted by hydroxy groups, hydroxyalkyl groups, amino groups, aminoalkyl groups, alkoxy groups, alkoxyalkyl groups, alkoxycarbonyl groups, alkoxycabonylalkyl groups or a combination of those functionalized groups;wherein Z1 to Z11 independently represent optionally substituted C1-C20 alkyl groups, with the provisos that: when a is not 0, Z3, Z4, and Z9 are methyl, ethyl, or propyl; wherein at least one of Z3, Z4, and Z9 is methyl, and at least one Z3, Z4, and Z9 is an ethyl or propyl,when b is not 0, Z5, Z6, and Z10 are methyl, ethyl, or propyl; wherein at least one of Z5, Z6, and Z10 is methyl, and at least one Z5, Z6, and Z10 is an ethyl or propyl, andwhen c is not 0, Z7, Z8, and Z11 are methyl, ethyl, or propyl; wherein at least one of Z7, Z8, and Z11 is methyl, and at least one Z7, Z8, and Z11 is an ethyl or propyl;wherein n represents an integer of from 0 to 200;wherein a, b, and c independently represent integers of from 0 to 20, with the proviso that a, b, and c are not simultaneously 0;wherein n=0; all of a, b, and c are 1;wherein a is 0; b and c are 1; and Z9 comprises a methyl group, an ethyl group, a propyl group, or a butyl group; andwherein b and c are not simultaneously 0. 2. The ophthalmic lens of claim 1, wherein the lens is a contact lens. 3. The ophthalmic lens of claim 1, wherein at least 25% of the polymer comprises residues of the compound. 4. The ophthalmic lens of claim 1, wherein L has the structure: wherein G is hydrogen or a hydrolyzable group;wherein k represents an integer of 0 to 6; andwherein m represents an integer of 1 to 3 when k is 0, and represents an integer of from 1 to 20 when k is not 0. 5. The ophthalmic lens of claim 4, wherein 1≦3k+m≦20. 6. An ophthalmic lens comprising a polymer comprising at least one residue of a compound having the structure: wherein M represents a radical-polymerizable group; wherein M is an acryloyloxy group or a methacryloyloxy group;wherein L has the structure: wherein G is hydrogen,wherein k represents an integer of 0 to 6, andwherein m represents an integer of 1 to 3 when k is 0, and represents an integer of 1 to 20 when k is not 0, with the proviso that 1≦3k+m≦20;wherein Z1 to Z11 independently represent optionally substituted C1-C20 alkyl groups, with the provisos that: when a is not 0, Z3, Z4, and Z9 are methyl, ethyl, or propyl; wherein at least one of Z3, Z4, and Z9 is methyl, and at least one Z3, Z4, and Z9 is ethyl or propyl,when b is not 0, Z5, Z6, and Z10 are methyl, ethyl, or propyl; wherein at least one of Z5, Z6, and Z10 is methyl, and at least one Z5, Z6, and Z10 is ethyl or propyl, andwhen c is not 0, Z7, Z8, and Z11 are methyl, ethyl, or propyl; wherein at least one of Z7, Z8, and Z11 is methyl, and at least one Z7, Z8, and Z11 is ethyl or propyl;wherein n represents an integer of from 0 to 200;wherein a, b, and c independently represent integers of from 0 to 20, with the proviso that a, b, and c are not simultaneously 0;wherein n=0; all of a, b, and c are 1;wherein a is 0; b and c are 1; and Z9 comprises a methyl group, an ethyl group, a propyl group, or a butyl group;wherein b and c are not simultaneously 0; andwherein the compound exhibits a hydrolysis resistance of at least about 90% at about 90° C. 7. The ophthalmic lens of claim 6, wherein the lens is a contact lens. 8. The ophthalmic lens of claim 6, wherein at least 25% of the polymer comprises residues of the compound. 9. An ophthalmic lens comprising a polymer comprising at least one residue of a compound having the structure: wherein p is 1, 2, or 3;wherein M represents a radical-polymerizable group;wherein L represents an optionally substituted divalent C1-C20 organic group;wherein R1, R2a, R2b, R3a, R3b, R4a, and R4b independently represent optionally substituted C1-C20 alkyl groups or optionally substituted C6-C20 aryl groups; andwherein the water content of the ophthalmic lens is from about 5% to about 50%. 10. The ophthalmic lens of claim 9, wherein the lens is a contact lens. 11. The ophthalmic lens of claim 9, wherein at least 25% of the polymer comprises residues of the compound. 12. The ophthalmic lens of claim 9, wherein M is an acryloyloxy group, a methacryloyloxy group, acrylamide group, methacrylamide group, N-vinylamide group, or styryl group. 13. The ophthalmic lens of claim 9, wherein M is an acryloyloxy group or a methacryloyloxy group. 14. The ophthalmic lens of claim 9, wherein L has the structure: wherein G is hydrogen or a hydrolyzable group;wherein k represents an integer of 0 to 6; andwherein m represents an integer of 1 to 3 when k is 0, and represents an integer of from 1 to 20 when k is not 0. 15. The ophthalmic lens of claim 14, wherein 1≦3k+m≦20.
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