Device, system, and method for targeted delivery of anti-inflammatory medicaments to a mammalian subject
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-031/00
A61K-031/192
A61K-031/195
출원번호
US-0660112
(2010-02-19)
등록번호
US-8926584
(2015-01-06)
발명자
/ 주소
Eckhoff, Philip A.
Hyde, Roderick A.
Ishikawa, Muriel Y.
Kare, Jordin T.
Leuthardt, Eric C.
Rivet, Dennis J.
Sweeney, Elizabeth A.
Wood, Jr., Lowell L.
Wood, Victoria Y. H.
출원인 / 주소
The Invention Science Fund I, LLC
대리인 / 주소
Dorsey & Whitney LLP
인용정보
피인용 횟수 :
0인용 특허 :
23
초록▼
A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates
A device, a system, or a method is described for treating a disease or a condition of one or more joints of articulating bone in a mammalian subject. The device provides one or more medicaments to one or more joints of the mammalian subject. A device is described that includes one or more substrates configured to contact one or more body contours in proximity to one or more joints of articulating bone of a mammalian subject; one or more sensors configured to monitor movement of the one or more body contours; and one or more applicators supported by the one or more substrates and configured to respond to the movement of the one or more body contours by injecting one or more medicaments to the one or more joint tissues of the mammalian subject.
대표청구항▼
1. A method comprising: positioning a device over one or more body contours of a mammalian subject, the one or more body contours at least partially covering one or more joints of articulating bone, wherein the device includes, one or more sheaths configured to contact the one or more body contours;
1. A method comprising: positioning a device over one or more body contours of a mammalian subject, the one or more body contours at least partially covering one or more joints of articulating bone, wherein the device includes, one or more sheaths configured to contact the one or more body contours;a plurality of applicators supported by the one or more sheaths and configured to inject one or more medicaments to one or more joint tissues of the mammalian subject; andone or more sensors, at least one of the one or more sensors being configured to monitor movement of the one or more body contours, and at least one of the one or more sensors being configured to detect one or more physiological conditions of the one or more joints;a controller in communication with the one or more sensors and configured to position the plurality of applicators;positioning the plurality of applicators near the one or more joints using the controller; andresponsive to the one or more sensors sensing movement, using the device, selectively injecting the one or more medicaments to the one or more joint tissues of the mammalian subject. 2. The method of claim 1, wherein the one or more applicators includes one or more high speed microjets, one or more microneedles, one or more microfine lances, one or more microfine cannulas, one or more microprojections, or one or more electrodes. 3. The method of claim 2, wherein the one or more applicators includes one or more high speed microjets. 4. The method of claim 3, wherein the high speed microjets are nanoliter-volume pulsed microjets. 5. The method of claim 3, wherein the one or more applicators further includes one or more microneedles, one or more microfine lances, or one or more microfine cannulas. 6. The method of claim 3, further including providing a component for transient mechanical/electrical acceleration of the one or more medicaments from the high speed microjets. 7. The method of claim 1, wherein at least one of the one or more sensors is implanted in the mammalian subject using the device. 8. The method of claim 1, wherein the one or more sheaths includes a sleeve-shaped article of clothing or a sleeve-shaped body covering. 9. The method of claim 8, wherein the one or more sheaths includes a shirt sleeve, a pant, a leg covering, a stocking, a bandage-like covering, a brace, a knee brace, an elbow brace, an ankle brace, a foot brace, a hand brace, or a spinal brace. 10. The method of claim 1, wherein the one or more sheaths includes one or more substrates attached to the one or more body contours by glue, suction, or suture. 11. The method of claim 1, wherein the one or more joint tissues includes one or more of a fibrous capsule, subsynovium, synovial membrane, synovium, joint cavity, synovial fluid, articular cartilage, subchondral bone, or ligament. 12. The method of claim 1, wherein the one or more joints includes a synovial joint, cartilaginous joint, or fibrous joint. 13. The method of claim 1, wherein the one or more sensors are configured to monitor joint movement, body movement, or gait of the mammalian subject. 14. The method of claim 1, wherein the one or more sensors are configured to monitor posture of the mammalian subject. 15. The method of claim 1, wherein the one or more sensors are configured to detect two or more physiological conditions of the mammalian subject. 16. The method of claim 15, wherein the one or more sensors are configured to detect tissue swelling, tissue pressure, tissue color, tissue temperature, environmental temperature, electrical property of tissue, optical property of tissue, perspiration, or presence of an analyte. 17. The method of claim 16, wherein the analyte includes an inflammatory marker, antibody, or cytokine. 18. The method of claim 1, wherein the one or more sensors are configured to determine quality of location or quality of contact placement of the one or more sheaths on the one or more body contours. 19. The method of claim 1, wherein the controller is configured to control release of the one or more medicaments from the one or more applicators. 20. The method of claim 19, wherein the controller is configured to control release of the one or more medicaments in concentration gradients in a time-dependent manner. 21. The method of claim 19, wherein the controller is configured to report quantity and frequency of dosage of the one or more medicaments. 22. The method of claim 19, wherein the controller is configured to control a maximum dosage of the one or more medicaments for a time period. 23. The method of claim 19, wherein the controller is configured to respond to the one or more sensors. 24. The method of claim 23, wherein the one or more sensors are configured to detect one or more conditions at one or more of the one or more joints and the controller is configured to control release of the one or more medicaments at others of the one or more joints of the mammalian subject. 25. The method of claim 24, wherein the one or more sensors are configured to detect movement of the one or more body contours. 26. The method of claim 1, wherein the one or more applicators further include tissue permeabilization components including one or more of electronics, ultrasonics, chemical permeation enhancer, iontophoresis, microdialysis, ultrafiltration, electromagnetic, electroosmosis, sonophoresis, microdialysis, suction, electroporation, thermal poration, microporation, heating component, or laser. 27. The method of claim 6, wherein the component for transient mechanical/electrical acceleration includes a fluid displacement actuator configured as one or more piezoelectric actuators, one or more springs, one or more solenoids, one or more magnets, one or more motors, or one or more compressed gas actuators. 28. The method of claim 6, wherein the component for mechanical/electrical acceleration applies concentration gradients of the one or more medicaments in a time-dependent manner. 29. The method of claim 1, wherein the one or more medicaments includes steroids, corticosteroids, analgesics, COX-2 inhibitors, or NSAID. 30. The method of claim 1, further including providing a pharmaceutical composition including the one or more medicaments in a thixotropic medium. 31. The method of claim 1, wherein the one or more applicators are configured to apply the one or more medicaments in a time-dependent manner. 32. The method of claim 31, wherein the one or more applicators are configured to apply the one or more medicaments in concentration gradients in the time-dependent manner. 33. The method of claim 1, further comprising, responsive to the one or more sensors sensing the one or more physiological conditions, using the device, selectively injecting the one or more medicaments to the one or more joint tissues of the mammalian subject.
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