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Devices and methods for determining the length of biopolymers and distances between probes bound thereto

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07K-001/26
  • G01N-033/487
  • G01N-027/327
출원번호 US-0567595 (2012-08-06)
등록번호 US-8926813 (2015-01-06)
발명자 / 주소
  • Oliver, John S.
출원인 / 주소
  • Nabsys, Inc.
대리인 / 주소
    Goodwin Procter LLP
인용정보 피인용 횟수 : 5  인용 특허 : 127

초록

Devices and methods for detecting the length of analytes, and/or sequencing analytes are provided in which two or more electrical signals are obtained as an analyte traverses a fluidic channel. Detection of the relative position of probes hybridized to a biopolymer and/or the length of the analyte (

대표청구항

1. A device for determining a length of an analyte by detecting electrical signals, the device comprising: a fluidic channel defined by a trench in a substrate;a pair of electromotive electrodes disposed at a first end and a second end of the fluidic channel; anda plurality of sensing electrodes dis

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이 특허를 인용한 특허 (5)

  1. Dimitrov, Valentin; Weiner, Nathan, Apparatus and methods for analysis of biomolecules using high frequency alternating current excitation.
  2. Oliver, John S., Devices and methods for determining the length of biopolymers and distances between probes bound thereto.
  3. Goldstein, Peter H., Methods for sequencing a biomolecule by detecting relative positions of hybridized probes.
  4. Pyzyna, Adam M.; Smith, Joshua T.; Wunsch, Benjamin H., Reproducible and manufacturable nanogaps for embedded transverse electrode pairs in nanochannels.
  5. Oliver, John S.; Tang, Jing, Use of longitudinally displaced nanoscale electrodes for voltage sensing of biomolecules and other analytes in fluidic channels.
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