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This document discusses, among other things, apparatus, systems, and methods for transvascularly stimulation of a nerve or nerve trunk. In an example, an apparatus is configured to transvascularly stimulate a nerve trunk through a blood vessel. The apparatus includes an expandable electrode that is

This document discusses, among other things, apparatus, systems, and methods for transvascularly stimulation of a nerve or nerve trunk. In an example, an apparatus is configured to transvascularly stimulate a nerve trunk through a blood vessel. The apparatus includes an expandable electrode that is chronically implantable in a blood vessel proximate a nerve trunk. The expandable electrode is configured to abut a predetermined surface area of the vessel wall along a predetermined length of the vessel. An electrical lead is coupled to the expandable electrode. An implantable pulse generator is coupled to the lead and configured to deliver an electrical stimulation signal to the electrode through the lead. In an example method, an electrical signal is delivered from an implanted medical device to an electrode chronically implanted in a blood vessel proximate a nerve trunk to transvascularly deliver neural stimulation from the electrode to the nerve trunk.

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1. An implantable apparatus for treating hypertension, comprising: an expandable electrode chronically implantable in a blood vessel and configured to abut an intravascular surface of the blood vessel;an implantable pulse generator configured to use the electrode in the blood vessel to transvascular

1. An implantable apparatus for treating hypertension, comprising: an expandable electrode chronically implantable in a blood vessel and configured to abut an intravascular surface of the blood vessel;an implantable pulse generator configured to use the electrode in the blood vessel to transvascularly deliver electrical stimulation from the electrode through a wall of the blood vessel to a targeted nerve on or near an extravascular surface of the blood vessel; anda controller and a memory configured to store instructions operable on by the controller to deliver an electrical stimulation therapy to treat hypertension using electrical stimulation of the nerve from the electrode in the blood vessel. 2. The apparatus of claim 1, wherein the nerve is a vagus nerve or a branch of the vagus nerve, and the implantable pulse generator is configured to use the electrode in the blood vessel to transvascularly stimulate the vagus nerve or the branch of the vagus nerve. 3. The apparatus of claim 2, wherein the blood vessel is a pulmonary artery, and the implantable pulse generator is configured to use the electrode in the pulmonary artery to transvascularly stimulate the vagus nerve or the branch of the vagus nerve. 4. The apparatus of claim 2, wherein the blood vessel is an internal jugular vein, and the implantable pulse generator is configured to use the electrode in the internal jugular vein to transvascularly stimulate the vagus nerve. 5. The apparatus of claim 2, wherein the blood vessel is an aortic arch, and the implantable pulse generator is configured to use the electrode in the aortic arch to transvascularly stimulate the vagus nerve. 6. The apparatus of claim 2, wherein the blood vessel is an azygos vein, and the implantable pulse generator is configured to use the electrode in the azygos vein to transvascularly stimulate the vagus nerve. 7. The apparatus of claim 1, wherein the blood vessel is a subclavian artery and the nerve is a cardiac nerve, and the implantable pulse generator is configured to use the electrode in the subclavian artery to transvascularly stimulate the cardiac nerve. 8. The apparatus of claim 1, wherein the nerve is a parasympathetic nerve. 9. The apparatus of claim 1, the nerve is a carotid sinus nerve, and the implantable pulse generator is configured to use the electrode in the blood vessel to transvascularly stimulate the carotid sinus nerve. 10. The apparatus of claim 1, wherein the expandable includes a drug-eluting component. 11. The apparatus of claim 10, wherein the drug-eluting component is configured to elute a drug to reduce inflammation. 12. The apparatus of claim 10, wherein the drug-eluting component is configured to elute a drug to prevent occlusion. 13. The apparatus of claim 1, wherein the expandable electrode includes a stent. 14. The apparatus of claim 1, wherein the expandable electrode includes a mesh, and at least part of the mesh is conductive. 15. The apparatus of claim 1, wherein the blood vessel is an internal jugular vein and the nerve is the carotid sinus nerve, and the implantable pulse generator is configured to use the electrode in the internal jugular vein to transvascularly stimulate the cardiac sinus nerve. 16. The apparatus of claim 1, wherein the blood vessel is a carotid artery and the nerve is the carotid sinus nerve, and the implantable pulse generator is configured to use the electrode in the carotid artery to transvascularly stimulate the cardiac sinus nerve. 17. The apparatus of claim 1, wherein the blood vessel is a blood vessel proximate to a nerve that innervates a kidney, wherein the implantable pulse generator is configured to use the electrode in the blood vessel to transvascularly stimulate the nerve that innervates the kidney. 18. A method for treating hypertension, comprising: chronically implanting an expandable electrode in a blood vessel in a patient who is indicated for a hypertension therapy, including expanding the electrode to abut an intravascular surface of the blood vessel proximate to a targeted nerve on or near an extravascular surface of the blood vessel; andtreating hypertension, including using an implantable pulse generator and the electrode in the blood vessel to transvascularly deliver electrical stimulation from the electrode through a wall of the blood vessel to the nerve on or near the extravascular surface of the blood vessel. 19. The method of claim 18, wherein the blood vessel is an internal jugular vein and the nerve is a carotid sinus nerve, wherein treating hypertension includes using the implantable pulse generator and the electrode chronically implanted in the internal jugular vein to stimulate the carotid sinus nerve. 20. The method of claim 18, wherein the blood vessel is a carotid artery and the nerve is a carotid sinus nerve, wherein treating hypertension includes using the implantable pulse generator and the electrode chronically implanted in the carotid artery to stimulate the carotid sinus nerve. 21. The method of claim 18, wherein the blood vessel is a pulmonary artery, and the nerve is a vagus nerve or a branch of the vagus nerve, wherein treating hypertension includes using the implantable pulse generator and the electrode chronically implanted in the pulmonary artery to stimulate the vagus nerve or the branch of the vagus nerve. 22. The method of claim 18, wherein the blood vessel is an internal jugular vein and the nerve is a vagus nerve, wherein treating hypertension includes using the implantable pulse generator and the electrode chronically implanted in the internal jugular vein to stimulate the vagus nerve. 23. The method of claim 18, wherein the blood vessel is an aortic arch and the nerve is a vagus nerve, wherein treating hypertension includes using the implantable pulse generator and the electrode chronically implanted in the aortic arch to stimulate the vagus nerve. 24. The method of claim 18, wherein the blood vessel is an azygos vein and the nerve is a vagus nerve, wherein treating hypertension includes using the implantable pulse generator and the electrode chronically implanted in the azygos vein to stimulate the vagus nerve. 25. The method of claim 18, wherein the blood vessel is a subclavian artery and the nerve is a vagus nerve, wherein treating hypertension includes using the implantable pulse generator and the electrode chronically implanted in the subclavian artery to stimulate the vagus nerve. 26. The method of claim 18, wherein chronically implanting an expandable electrode in a blood vessel includes chronically implanting an expandable electrode with a drug-eluting component configured to elute a drug to reduce inflammation. 27. The method of claim 18, wherein chronically implanting an expandable electrode in a blood vessel includes chronically implanting an expandable electrode with a drug-eluting component configured to elute a drug to prevent occlusion. 28. The method of claim 18, wherein chronically implanting an expandable electrode in a blood vessel includes chronically implanting the electrode in a blood vessel proximate to a nerve that innervates a kidney, and treating hypertension includes using the implantable pulse generator and the electrode to stimulate the nerve that innervates the kidney.