Biodegradable osmotic pump implant for drug delivery
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61F-013/00
A61F-002/00
A61K-009/52
A61K-009/14
A61K-009/22
A61K-009/00
출원번호
US-0939720
(2013-07-11)
등록번호
US-8932618
(2015-01-13)
발명자
/ 주소
Blaskovich, Phillip D.
Ohri, Rachit
Bennett, Steven L.
출원인 / 주소
Confluent Surgical, Inc.
대리인 / 주소
Carter DeLuca Farrell & Schmidt LLP
인용정보
피인용 횟수 :
0인용 특허 :
43
초록▼
The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable
The present disclosure relates to a drug delivery device including a biodegradable housing and a hydrogel within the biodegradable housing. The housing, the hydrogel, or both, may include a bioactive agent. Also disclosed is a method of drug delivery including the steps of forming the biodegradable housing, in embodiments a hydrogel, suspending a bioactive agent in the hydrogel, and introducing a second hydrogel and/or precursors of a second hydrogel into the biodegradable housing.
대표청구항▼
1. An implantable drug delivery device comprising: a biodegradable pouch comprising a biodegradable polymeric material;at least two barrier layers within the biodegradable pouch, the at least two barrier layers forming at least three compartments within the biodegradable pouch; anda biodegradable hy
1. An implantable drug delivery device comprising: a biodegradable pouch comprising a biodegradable polymeric material;at least two barrier layers within the biodegradable pouch, the at least two barrier layers forming at least three compartments within the biodegradable pouch; anda biodegradable hydrogel within said biodegradable pouch;wherein the biodegradable hydrogel comprises a bioactive agent, andwherein each of the at least two barrier layers possess at least one degradable region. 2. The implantable drug delivery device of claim 1, wherein the biodegradable hydrogel within the biodegradable pouch is formed of a first precursor comprising electrophilic groups and a second precursor comprising nucleophilic groups. 3. The implantable drug delivery device of claim 2, wherein the electrophilic groups of the first hydrogel precursor comprise N-hydroxysuccinimides and the nucleophilic groups of the second hydrogel precursor comprise amines. 4. The implantable drug delivery device of claim 1, wherein the biodegradable polymeric material comprises a second hydrogel capable of a changing in size by a weight decrease from about 1% to about 50% or a weight increase from about 0% to about 50%, and the biodegradable hydrogel swells by an amount from about 40% by weight to about 600% by weight. 5. The implantable drug delivery device of claim 1, wherein the biodegradable polymeric material forming the biodegradable pouch comprises a first precursor comprising electrophilic groups and a second precursor comprising nucleophilic groups. 6. The implantable drug delivery device of claim 5, wherein the first precursor comprises a multi-armed precursor possessing a core and arms, the arms each comprising a polyethylene glycol having a molecular weight from about 250 to about 5000. 7. The drug delivery device of claim 6, wherein the core is selected from the group consisting of polyethers, polyamino acids, proteins, and polysaccharides. 8. The implantable drug delivery device of claim 6, wherein the core is selected from the group consisting of polyethylene glycol, polyethylene oxide, polyethylene oxide-co-polypropylene oxide, co-polyethylene oxide copolymers, polyvinyl alcohol, polyvinyl pyrrolidinone, dextran, chitosan, carboxymethylcellulose, oxidized cellulose, derivatives thereof, and combinations thereof. 9. The implantable drug delivery device of claim 5, wherein the nucleophilic groups comprise amines. 10. The implantable drug delivery device of claim 1, wherein the biodegradable polymeric material comprises a low-swelling hydrogel capable of changing in size by a weight decrease from about 5% to about 30% or a weight increase from about 10% to about 40%, and the biodegradable hydrogel swells by an amount from about 100% by weight to about 400% by weight. 11. The implantable drug delivery of claim 1, wherein the biodegradable polymeric material is selected from the group consisting of oxidized cellulose, polylactide, polyglycolide, polylactide-co-glycolide copolymer, and combinations thereof. 12. The implantable drug delivery device of claim 1, wherein the biodegradable pouch further comprises an inner layer and at least one outer layer. 13. The implantable drug delivery device of claim 12, wherein the at least one outer layer is selected from the group consisting of oxidized cellulose, polylactide, polyglycolide, polylactide-co-glycolide copolymer, and combinations thereof. 14. The implantable drug delivery device of claim 12, wherein the at least one outer layer comprises a molecular weight cut off membrane. 15. The implantable drug delivery device of claim 1, wherein the bioactive agent is selected from the group consisting of local anesthetics, vitamins, hormones, and combinations thereof. 16. The implantable drug delivery device of claim 1, wherein the biodegradable pouch is semi-permeable. 17. The implantable drug delivery device of claim 1, wherein the bioactive agent is encapsulated in a polymeric microcapsule. 18. The implantable drug delivery device of claim 1, wherein the implantable drug delivery device possesses a shape selected from the group consisting of circular, discs, rods, cylinders, capsules, spheres, ovoids, pinwheels, nautilus, and combinations thereof.
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