Medicament delivery device for administration of opioid antagonists including formulations for naloxone
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61M-005/32
A61M-005/20
A61M-011/00
A61M-015/08
출원번호
US-0062516
(2013-10-24)
등록번호
US-8939943
(2015-01-27)
발명자
/ 주소
Edwards, Eric S.
Edwards, Evan T.
Licata, Mark J.
Meyers, Paul F.
Blondino, Frank E.
출원인 / 주소
kaleo, Inc.
대리인 / 주소
Cooley LLP
인용정보
피인용 횟수 :
25인용 특허 :
327
초록▼
Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a nalo
Medicament delivery devices for administration of opioid antagonists are described herein. In some embodiments, an apparatus includes a housing, a medicament container disposed within the housing and an energy storage member disposed within the housing. The medicament container is filled with a naloxone composition that includes naloxone or salts thereof, a tonicity-adjusting agent, and a pH-adjusting agent, whereby the osmolality of the naloxone composition ranges from about 250-350 mOsm and the pH ranges from about 3-5. The energy storage member is configured to produce a force to deliver the naloxone composition.
대표청구항▼
1. An apparatus, comprising: a housing;a medicament container disposed within the housing;a movable member coupled to the medicament container and a needle, the movable member configured to move within the housing in a first direction between a first position and a second position in response to a f
1. An apparatus, comprising: a housing;a medicament container disposed within the housing;a movable member coupled to the medicament container and a needle, the movable member configured to move within the housing in a first direction between a first position and a second position in response to a force produced by an energy storage member, the needle disposed within the housing when the movable member is in the first position, a portion of the needle disposed outside of the housing when the movable member is in the second position;a lock portion configured to engage a portion of the housing when the movable member is in the first position to limit movement of the movable member in a second direction, the lock portion and the movable member monolithically formed; anda biasing member configured to move the movable member in the second direction when the movable member is in the second position. 2. The apparatus of claim 1, wherein: the housing defines an opening; andthe lock portion of the movable member includes a protrusion configured to be disposed within the opening when the movable member is in the first position. 3. The apparatus of claim 1, wherein the lock portion of the movable member is configured to deform when the movable member moves from the first position towards the second position. 4. The apparatus of claim 1, wherein: the housing defines an opening; andthe lock portion of the movable member includes a protrusion configured to be disposed within the opening when the movable member is in the first position, the lock portion configured to deform to disengage the protrusion from within the opening when the movable member moves from the first position towards the second position. 5. The apparatus of claim 1, wherein the movable member includes a release portion, the release portion configured to interface with a release member when the movable member is in the second position to release the force from the movable member. 6. The apparatus of claim 1, wherein the movable member is a first movable member, the apparatus further comprising: a second movable member configured to move relative to the first movable member when the first movable member is in the second position to convey a medicament from the medicament container via the needle. 7. The apparatus of claim 1, wherein the medicament container contains a naloxone composition. 8. The apparatus of claim 1, wherein: the medicament container contains a naloxone composition and an elastomeric member disposed within the medicament container, at least a portion of the elastomeric member being coated with a silicone-based material; andat least a portion of the force produced by the energy storage member is exerted on the elastomeric member when the movable member is in the second position to deliver the naloxone composition via the needle. 9. The apparatus of claim 1, wherein: the housing defines a first opening and a second opening;the lock portion of the movable member includes a protrusion configured to be disposed within the first opening when the movable member is in the first position; anda portion of the medicament container configured to be aligned with the second opening when the movable member is in the second position such that a contents of the medicament container are visible via the second opening. 10. An apparatus, comprising: a housing defining a first opening and a second opening;a medicament container disposed within the housing, the medicament container containing a medicament and configured to be coupled to a needle; anda movable assembly coupled to the medicament container, the movable assembly including a first movable member, a second movable member and an elastomeric member, the first movable member configured to move within the housing between a first position and a second position in response to a force produced by an energy storage member, the needle disposed within the housing when the first movable member is in the first position, a portion of the needle disposed outside of the housing when the first movable member is in the second position, the second movable member configured to move the elastomeric member within the medicament container when the first movable member is in the second position to convey a medicament from the medicament container via the needle,a lock portion of the first movable member configured to be disposed within the first opening of the housing when the first movable member is in the first position, a portion of the movable assembly configured to be aligned with the second opening to produce a visual indication that the medicament has been conveyed. 11. The apparatus of claim 10, wherein the lock portion of the first movable member is configured to limit movement of the first movable member within the housing. 12. The apparatus of claim 10, wherein the first movable member moves in a first direction from the first position to the second position, the lock portion of the first movable member configured to limit movement of the first movable member in a second direction when the first movable member is in the first position. 13. The apparatus of claim 12, further comprising: a biasing member configured to move the first movable member in the second direction when the first movable member is in the second position. 14. The apparatus of claim 12, wherein the lock portion of the first movable member is configured to deform when the first movable member moves from the first position towards the second position. 15. The apparatus of claim 10, wherein the housing defines a third opening through which the portion of the needle is disposed when the first movable member is in the second position, the apparatus further comprising: a cover configured to be removably coupled to the housing, the cover configured to cover the third opening of the housing when the cover is coupled to the housing, the cover defining a cover opening configured to be aligned with the second opening of the housing when the cover is coupled to the housing. 16. The apparatus of claim 10, wherein the medicament is a naloxone composition. 17. The apparatus of claim 10, wherein: the medicament is a naloxone composition;at least a portion of the elastomeric member is coated with a silicone-based material; andat least a portion of the force produced by the energy storage member is exerted on the elastomeric member when the first movable member is in the second position to deliver the naloxone composition via the needle. 18. The apparatus of claim 10, wherein the first movable member includes a release portion configured to interface with the second movable member to release the force from the first movable member. 19. An apparatus, comprising: a housing defining a first opening, a second opening and a third opening;a medicament container disposed within the housing, the medicament container including a medicament and configured to be coupled to a needle;a movable assembly coupled to the medicament container, the movable assembly configured to move within the housing in response to a force produced by an energy storage member to move the needle from a first needle position to a second needle position, the needle disposed within the housing when the needle is in the first needle position, a portion of the needle disposed outside of the housing via the third opening when the needle is in the second needle position, a portion of the movable assembly configured to move within the medicament container when the needle is in the second needle position to convey the medicament from the medicament container via the needle, the portion of the movable assembly configured to be aligned with the second opening to produce a visual indication that the medicament has been conveyed, a lock portion of the movable assembly configured to be disposed within the first opening of the housing to limit movement of the movable assembly; anda cover configured to be removably coupled to the housing, the cover configured to cover the third opening of the housing when the cover is coupled to the housing, the cover defining a cover opening configured to correspond with the second opening of the housing when the cover is coupled to the housing. 20. The apparatus of claim 19, wherein the movable assembly includes a carrier configured to move in a first direction from a first position to a second position to move the needle from the first needle position to the second needle position, the lock portion configured to limit movement of the carrier in a second direction when the carrier is in the first position. 21. The apparatus of claim 20, further comprising: a biasing member configured to move the carrier in the second direction when the carrier is in the second position. 22. The apparatus of claim 19, wherein the lock portion is configured to deform when the needle moves from the first needle position towards the second needle position. 23. The apparatus of claim 19, wherein the movable includes a carrier configured to move the medicament container within the housing, the portion of the movable assembly configured to move relative to the carrier to convey a medicament from the medicament container via the needle. 24. The apparatus of claim 19, wherein the medicament is a naloxone composition. 25. The apparatus of claim 19, wherein: the medicament is a naloxone composition;the portion of the movable assembly includes an elastomeric member is coated with a silicone-based material; andat least a portion of the force produced by the energy storage member is exerted on the elastomeric member to deliver the naloxone composition via the needle.
연구과제 타임라인
LOADING...
LOADING...
LOADING...
LOADING...
LOADING...
이 특허에 인용된 특허 (327)
Caffrey James L., (+) naloxone and epinephrine combination therapy.
Say James ; Tomasco Michael F. ; Heller Adam ; Gal Yoram,ILX ; Aria Behrad ; Heller Ephraim ; Plante Phillip John ; Vreeke Mark S. ; Friedman Keith A. ; Colman Fredric C., Analyte monitoring device and methods of use.
Adams, Matthew Robert; Fourt, Jesse Arnold; Kaplan, Jonathan I.; Silberschatz, Paul Joseph; Yurchenco, James R., Automatic injection device with delay mechanism including dual functioning biasing member.
Schluter Eberhardt (Elfenbeinweg 13 Hamburg 65 DEX) Scheller Albert (Gaggenau DEX) Sprenger Rolf (Gaggenau/Winkel DEX), Automatic injection device, including an ampoule or a cartridge for an injection device.
Wilmot John G. ; Goldberg Jeffrey L. ; Page Jon ; Ketcham Cliff ; Castleberry Jeffrey P. ; Morton Jason ; Edsall Dave ; Boyd Robert R. ; Hill Robert L., Automatic injector.
Sarnoff Stanley J. (Bethesda MD) Tarello William R. (Bethesda MD) Lopez Claudio (Silver Spring MD) Karcher Daniel W. (Great Falls VA), Automatic medicament ingredient mixing and injecting apparatus.
Wanderer Alan A. (1075 E. Radcliffe Englewood CO 80110) Sagstetter William E. (2217 Grove Denver CO 80210), Combination needle shield/needle guard device for a hypodermic syringe with a permanently attached needle.
Raven, Sophie Rebecca; Young, Matthew Egerton; Greenhalgh, Paul; Kirkwood, Stephen Pilip; Mathews, Colin James; Daintrey, Joseph William; Wilmot, John G., Container for medicament automatic injector and automatic injector adapted therefor.
Pearson William R. (Laurel MD) Spady David Edward (Centreville VA) Lopez Claudio (Darnstown MD) Lee Hyung J. (Cary NC) Wilmot John G. (Germantown MD) Dalling N. Lawrence (Cross Junction VA), Dental cartridge assembly auto-injector with protective needle cover.
Kaufhold ; Jr. Harry (9711 Ebb St. Houston TX 77089) Jasso Martin (Houston TX) Kruckeberg Gerald E. (Cypress TX), Disposable syringe with automatic needle retraction.
Kaufhold ; Jr. Harry (9711 Ebb St. Houston TX 77089) Jasso Martin (Houston TX) Kruckeberg Gerald E. (Cypress TX), Disposable syringe with automatic needle retraction.
Gasaway Jack S. (Irvine CA) Parsons J. Stuart (Laguna Niguel CA) Harshman Robert L. (Chino Hills CA), Gas-pressure-regulated needleless injection system.
Dedig, James Albert; Joyce, Thomas P.; Spohn, Michael A.; Haury, John A.; O'Donnell, Gregory J., Injector systems and syringe adapters for use therewith.
Diaz, Luis A.; Hershberger, David; Strickler, Michael; Toman, Jason Dee; Malackowski, Donald W.; Huyser, Richard Franklin, Integrated medication delivery system.
Gravel Marian ; Gasparello Benjamin ; Ferraro Joseph ; Sharma Ashutosh ; Strowe Robert John ; Bendek Antonio A. ; Uschold Robert C. ; Antoshkiw William Thomas, Integrated system including medication delivery pen, blood monitoring device, and lancer.
Mishelevich David J. (Cupertino CA) Lanpher Ted W. (Atherton CA) Lanpher Gregory B. (York CA) Long James (Sunnyvale CA), Intelligent inhaler providing feedback to both patient and medical professional.
Simonsen, Jan Henning; Poulsen, Jens Ulrik; Rokkjaer, Kent Halfdan; Christensen, Lars Hofmann; Aasmul, S.o slashed.ren; Iav, Steffen, Medical system and a method of controlling the system for use by a patient for medical self treatment.
Edwards, Eric S.; Edwards, Evan T.; Licata, Mark J.; Blondino, Frank E., Medicament delivery device for administration of opioid antagonists including formulations for naloxone.
Moberg, Sheldon B.; Causey, III, James D.; Bare, Rex O.; Scherer, Andrew J.; Sargent, Bradley J., Methods, apparatuses, and uses for infusion pump fluid pressure and force detection.
Pawelka Gerhard E. F. (Lexington MA) Stringer Christopher J. (San Francisco CA) Marsh Matthew (San Francisco CA) Karshmer David L. (San Francisco CA) Lada Christopher O. (Palo Alto CA) Schoenberg Ste, Multi-cartridge medication injection device.
Haber Terry M. (Lake Forest CA) Smedley William H. (Lake Elsinore CA) Foster Clark B. (Laguna Niguel CA), Multiple pharmaceutical dispenser with accumulator.
McKinnon ; Jr. Charles N. (Laguna Niguel CA) Peterson Steven F. (West Linn OR) Smith Paul E. (Tualatin OR) Nakagawa Takaaki (Tigard OR) Bartholomew Victor L. (Tigard OR), Needleless hypodermic injection device.
Peterson Steven F. (West Linn OR) McKinnon ; Jr. Charles N. (Laguna Niguel CA) Smith Paul E. (Tualatin OR) Nakagawa Takaaki (Tigard OR) Bartholomew Victor L. (Tigard OR), Needleless hypodermic injection methods and device.
Haber Terry M. (Lake Forest CA) Smedley William H. (Lake Elsinore CA) Foster Clark B. (Laguna Niguel CA), Pharmaceutical component-mixing delivery assembly.
Haber Terry M. (Lake Forest CA) Foster Clark B. (Laguna Niguel CA) Smedley William H. (Lake Elsinore CA), Reusable pharmaceutical dispenser with full stroke indicator.
Kramer George C. (Galveston TX) Spoon Herbert H. (San Antonio TX) Miller Larry J. (Spring Branch TX) Collette David J. (San Antonio TX) Zamorano Rubn G. (San Antonio TX) Jenkinson Joel P. (Galveston , System and method for rapid vascular drug delivery.
Claeys Ronald W. (1462 “I”St. Springfield OR 97477) Decamp Gary S. (2595 Elysium Eugene OR 97401), System for verifying and recording drug administration to a patient.
Neel, Gary T.; Bell, Douglas E.; Wong, T. Philip; Voss, Houston F.; Caban, Allan Javier; Boehm, David K., Systems and methods for blood glucose sensing.
Mann, Alfred E.; Purvis, Richard E.; Mastrototaro, John J.; Causey, James D.; Henke, James; Hong, Peter; Livingston, John H.; Hague, Clifford W.; Hite, Brad T., Telemetered characteristic monitor system and method of using the same.
Smedley William H. (33285 Blanche Dr. Lake Elsinore CA 92330) Foster Clark B. (23631 Wakefield Ct. Laguna Niguel CA 92677) Haber Terry M. (25011 Castlewood Lake Forest CA 92630) ..RT: 628271 19901214, Variable proportion dispenser.
Brant Arthur ; Mandell Kenneth ; Rader R. Scott ; Walsh Alexander ; deJuan ; Jr. Eugene ; Greenberg Robert, Voice command and control medical care system.
Edwards, Eric S.; Edwards, Evan T.; Licata, Mark J.; Meyers, Paul F.; Weinzierl, David A., Apparatus and methods for self-administration of vaccines and other medicaments.
Edwards, Eric S.; Edwards, Evan T.; Licata, Mark J.; Meyers, Paul F.; Weinzierl, David A., Apparatus and methods for self-administration of vaccines and other medicaments.
Edwards, Eric S.; Edwards, Evan T.; Licata, Mark J.; Meyers, Paul F.; Blondino, Frank E., Devices and methods for delivering medicaments from a multi-chamber container.
Edwards, Eric S.; Edwards, Evan T.; Licata, Mark J.; Meyers, Paul F.; Blondino, Frank E., Devices and methods for delivering medicaments from a multi-chamber container.
Blondino, Frank E.; Edwards, Eric S.; Edwards, Evan T.; Kelley, Glen L.; Meyers, Paul F., Devices and methods for delivering opioid antagonists including formulations for naloxone.
Edwards, Eric S.; Edwards, Evan T.; Licata, Mark J.; Meyers, Paul F., Devices, systems and methods for locating and interacting with medicament delivery systems.
Edwards, Eric S.; Edwards, Evan T.; Licata, Mark J.; Meyers, Paul F., Devices, systems and methods for locating and interacting with medicament delivery systems.
Edwards, Eric S.; Edwards, Evan T.; Licata, Mark J.; Meyers, Paul F., Devices, systems and methods for locating and interacting with medicament delivery systems.
Edwards, Eric S.; Edwards, Evan T.; Licata, Mark J.; Meyers, Paul F.; Weinzierl, David A.; Williamson, IV, T. Spencer, Medical injector with compliance tracking and monitoring.
Edwards, Eric S.; Edwards, Evan T.; Licata, Mark J.; Meyers, Paul F.; Weinzierl, David A.; Williamson, IV, T. Spencer, Medical injector with compliance tracking and monitoring.
Edwards, Eric S.; Edwards, Evan T.; Licata, Mark J.; Blondino, Frank E., Medicament delivery device for administration of opioid antagonists including formulations for naloxone.
Edwards, Eric S.; Edwards, Evan T.; Licata, Mark J.; Blondino, Frank E., Medicament delivery device for administration of opioid antagonists including formulations for naloxone.
Edwards, Eric S.; Edwards, Evan T.; Licata, Mark J.; Meyers, Paul F.; Blondino, Frank E., Medicament delivery device for administration of opioid antagonists including formulations for naloxone.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.