Implantable electroacupuncture device and method for treating dyslipidemia
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/05
A61H-039/00
출원번호
US-0736041
(2013-01-07)
등록번호
US-8942816
(2015-01-27)
발명자
/ 주소
Greiner, Jeffrey H.
Peterson, David K. L.
Thenuwara, Chuladatta
Greiner, Stacy O.
출원인 / 주소
Valencia Technologies Corporation
대리인 / 주소
Gold, Bryant R.
인용정보
피인용 횟수 :
3인용 특허 :
35
초록▼
An Implantable ElectroAcupuncture Device (IEAD) treats dyslipidemia conditions of a patient through application of stimulation pulses applied at acupoint ST40, or its underlying nerves saphenous and peroneal. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture
An Implantable ElectroAcupuncture Device (IEAD) treats dyslipidemia conditions of a patient through application of stimulation pulses applied at acupoint ST40, or its underlying nerves saphenous and peroneal. The IEAD comprises an implantable, coin-sized, self-contained, leadless electroacupuncture device having at least two electrodes attached to an outside surface of its housing. The device generates stimulation pulses in accordance with a specified stimulation regimen. Power management circuitry within the device allows a primary battery, having a high internal impedance, to be used to power the device. The stimulation regimen generates stimulation pulses during a stimulation session of duration T3 minutes applied every T4 minutes. The duty cycle, or ratio T3/T4, is very low, no greater than 0.05. The low duty cycle and careful power management allow the IEAD to perform its intended function for several years.
대표청구항▼
1. A method of treating dyslipidemia conditions in a patient using a small, leadless, implantable electroacupuncture (EA) device powered by a small disc primary battery having a specified nominal output voltage of 3 volts, and having an internal impedance of at least 5 ohms, the implantable EA devic
1. A method of treating dyslipidemia conditions in a patient using a small, leadless, implantable electroacupuncture (EA) device powered by a small disc primary battery having a specified nominal output voltage of 3 volts, and having an internal impedance of at least 5 ohms, the implantable EA device (IEAD) being configured, using electronic circuitry within the IEAD, to generate EA stimulation pulses in accordance with a specified stimulation regimen and apply the EA stimulation pulses through at least two electrodes/arrays located on the housing of the IEAD to the patient's body tissue at a selected target tissue stimulation site, said at least two electrodes/arrays comprising at least one central electrode/array of a first polarity, having a maximum width of no more than 7 mm, centrally located on a first surface of the small IEAD housing, and at least one annular electrode/array of a second polarity spaced apart from the central electrode/array by at least 5 mm measured from the edge of the annular electrode/array closest to the central electrode/array to the center of the central electrode/array, said method comprising: (a) implanting the IEAD below the skin surface of the patient at the selected target stimulation site, the target stimulation site being selected from the group of target stimulation sites comprising acupoint ST40, and underlying nerves saphenous and peroneal, with the first surface of the IEAD facing inwardly into the patient's body tissue at the selected target stimulation site;(b) enabling the IEAD to provide stimulation pulses in accordance with a stimulation regimen that provides a stimulation session at a rate of once every T4 minutes, with each stimulation session having a duration of T3 minutes, where the ratio of T3/T4 is no greater than 0.05. 2. The method of claim 1 further including setting the time T4 to be at least 1440 minutes [1 day], but no more than about 20,160 minutes [14 days]. 3. The method of claim 2 further including setting T3, the duration of the stimulation session, to a value between 20 minutes and 60 minutes. 4. The method of claim 2 further including setting the stimulation pulses during a stimulation session to have a duration of T1 seconds, that occur at a rate of once every T2 seconds, where the ratio of T1/T2 is no greater than 0.01. 5. The method of claim 4 further including setting the time T1 to be 0.1 to 1.0 millisecond and the time T2 to be 250 to 1000 milliseconds. 6. The method of claim 1 further including controlling the electronic circuits within the IEAD to limit instantaneous current drawn from the small disc primary battery so that the output voltage of the primary battery does not drop more than about 11% below the output voltage of the primary battery when current is being drawn from the primary battery, where the output voltage of the primary battery is equal to the specified nominal output voltage of the primary battery less the voltage drop caused by the instantaneous current flowing through the internal impedance of the primary battery. 7. The method of claim 6 wherein the electronic circuitry within the IEAD includes a boost converter circuit, and wherein the method of controlling the electronic circuits within the IEAD to limit the instantaneous current drawn from the battery comprises modulating the operation of the boost converter circuit between an ON state and an OFF state.
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