초록 ▼

Embodiments of the invention relate to a curable nucleus pulposus implant having water absorption and swelling capabilities, compositions for producing the curable nucleus pulposus implants, and methods of using the curable nucleus pulposus implants. The curable nucleus pulposus implant can be creat

Embodiments of the invention relate to a curable nucleus pulposus implant having water absorption and swelling capabilities, compositions for producing the curable nucleus pulposus implants, and methods of using the curable nucleus pulposus implants. The curable nucleus pulposus implant can be created from a polymer blend composition comprising a ratio of a curable material and at least one hydrophilic polymer. The resulting polymer blend composition may be used to generate curable nucleus pulposus implants to treat a number of disease and/or disorders, such as herniated discs. The curable nucleus pulposus implants may further contain polyelectrolytes and elastomer compounds, as well as pharmacological and biological agents.

대표청구항 ▼

1. An in-situ three-part formable nucleus pulposus implant composition, comprising a first part, a second part and a third part that when mixed together in-situ provides a cured polyurethane implant; said first part comprising an in-situ curable polymerizable material comprising 2,4′-diphenylmethane

1. An in-situ three-part formable nucleus pulposus implant composition, comprising a first part, a second part and a third part that when mixed together in-situ provides a cured polyurethane implant; said first part comprising an in-situ curable polymerizable material comprising 2,4′-diphenylmethane diisocyanate, 4,4′-diphenylmethane diisocyanate, and toluene diisocyanate;said second part comprising at least one hydrophilic polymer, wherein the polymerizable material and the at least one hydrophilic polymer are present in a ratio of about 1:1 to about 19:1, respectively, the hydrophilic polymer comprising at least one of polyacrylic acid, polyacrylamides, or poly(N-vinyl-2-pyrrolidone),said third part comprising at least one therapeutic agent selected the group consisting of antibiotics, analgesics, anti-inflammatory drugs, steroids, anti-viral and anti-retroviral compounds, therapeutic proteins, therapeutic peptides, and therapeutic nucleic acids; andwherein said in-situ three-part formable composition polymerizes inside a partially evacuated intervertebral disc space to form a polymerized implant. 2. The composition according to claim 1, wherein the polymerizable material and the at least one hydrophilic polymer are present in a ratio of about 9:1, respectively. 3. The composition of claim 1, wherein the at least one hydrophilic polymer is selected from the group consisting of collagen, gelatin, albumin, keratin, elastin, silk, hyaluronic acid and derivatives thereof, proteoglycan, glucomannan gel, polysaccharides, and combinations thereof. 4. The composition of claim 1, wherein the at least one hydrophilic polymer is a hydrogel selected from the group consisting of polyvinyl alcohol, poly(acrylonitrile-acrylic acid), polyurethanes, polyethylene glycol, polyethyleneoxide, polyacrylates, poly(2-hydroxy ethyl methacrylate), copolymers of acrylates with N-vinyl pyrrolidone, N-vinyl lactams, acrylamide, polyurethanes, and combinations thereof. 5. The composition of claim 1, further comprising an elastomer material. 6. The composition of claim 5, wherein the elastomer is selected from the group consisting of silicone, polyurethane, polybutadiene, polyolefins, such as polyisobutylene and polyisoprene, neoprene, nitrile, vulcanized rubber and combinations thereof. 7. The composition of claim 5, wherein the elastomer is present in a concentration of about 5-40% by weight of the total composition. 8. The composition of claim 1, further comprising a polyelectrolyte. 9. The composition of claim 8, wherein the polyelectrolyte is selected from the group consisting of proteins, nucleic acids, sulfonated styrene, polyacrylic acids, and combinations thereof. 10. The composition of claim 8, wherein the polyelectrolyte is selected from the group consisting of carboxymethylcellulose, polyacrylic acid, xantham gum, pectins, polystyrene sulfate, polymethacrylic acid, polyallylamine hydrochloride, carrageenan, and combinations thereof. 11. The composition of claim 8, wherein the polyelectrolyte is present in a concentration of about 5-100% by weight of the hydrophilic polymer. 12. The composition of claim 1, wherein said antibiotics is selected from the group consisting of amoxicillin, beta-lactamases, aminoglycosides, beta-lactam (glycopeptide), clindamycin, chloramphenicol, cephalosporins, ciprofloxacin, erythromycin, fluoroquinolones, macrolides, metronidazole, penicillins, quinolones, rapamycin, rifampin, streptomycin, sulfonamide, tetracyclines, trimethoprim, trimethoprim-sulfamthoxazole, and vancomycin. 13. The compositions of claim 1 wherein said therapeutic nucleic acids encode proteins/peptides selected from the group consisting of Bone Morphogenetic Proteins (BMPs), including BMP-1, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, BMP-8, BMP-9, BMP-10, BMP-11, BMP-12, BMP-13, BMP-15, BMP-16, BMP-17, and MBP-18; Vascular Endothelial Growth Factors (VEGFs), including VEGF-A, VEGF-B, VEGF-C, VEGF-D and VEGF-E; Connective Tissue Growth Factors (CTGFs), including CTGF-1, CTGF-2, and CTGF-3; Osteoprotegerin, Transforming Growth Factor betas (TGF-βs), including TGF-β1, TGF-β2, TGF-β3; inhibitors for tumor necrosis factor (e.g., anti-TNFα); and Platelet Derived Growth Factors (PDGFs), including PDGF-A, PDGF-B, PDGF-C, and PDGF-D. 14. A method of treating or preventing a spinal disease or disorder, comprising a) surgically evacuating at least a portion of nucleus pulposus material and any free disc fragments from at least one intervertebral disc of a patient;b) providing the three-part formable nucleus pulposus implant composition of claim 1; andc) implanting each of the parts of said three-part formable nucleus pulposus implant composition of claim 1 separately into the at least partially evacuated intervertebral disc space of the patient whereby the in-situ three-part formable polymer composition polymerizes inside the partially evacuated intervertebral disc space to form a polymerized implant. 15. The method of claim 14, further comprising measuring the volume of the at least partially evacuated intervertebral disc space by an inflatable saline balloon prior to preparing implanting the polymer blend composition. 16. The method of claim 14, wherein the spinal disease or disorder is selected from the group consisting of bulging disc(s); herniated disc(s); spinal injury due to trauma; age-related degeneration or failure of spinal column components; spinal instability; discogenic back pain; intervertebral osteochondrosis; spondylolisthesis; spinal infection; spinal tumors; arthritis of the spine, and any combination or combinations thereof. 17. The method of claim 14, wherein the polymerizable material is a polyfunctional isocyanate based polymerizable material. 18. The method of claim 14, wherein the polymerizable material is a-three-part polymerizable material. 19. The method of claim 18, wherein the two-part polymerizable material forms a polyurethane and has as one part a diisocyanate or polymeric isocyanate and as the other part a polyol. 20. The method of claim 19, wherein said diisocyanate is 2,4-toluene diisocyanate or 2,6-toluene diisocyanate, and said in-situ curable polymerizable a mixture further comprises 2,2′ diphenylmethane diisocyanate. 21. The method of claim 19, wherein the polyol is selected from the group consisting of polycaprolactone polyols, polycarbonate polyols, polyester polyols, polytetrahydrofuran polyol, and mixtures thereof. 22. The method of claim 18, wherein a catalyst is added to one of the three parts of the polymerizable material forming a polyurethane. 23. The method of claim 22, wherein the catalyst is selected from the group consisting of tin esters, tin alkylesters, tin mercaptides, amines, tertiary amines, dibutyl tin dilaurate, and mixtures thereof. 24. The method of claim 18, wherein low molecular weight diols are added to one part of the three-part polymerizabie material forming a polyurethane. 25. The method of claim 14, wherein the polymerizabie material is a light activated polymerizabie material. 26. The method of claim 25, wherein the light activated polymerizabie material comprises a mixture of a polyfunctional urethane acrylate or polyfunctional urethane methacrylate and a polyfunctional acrylate resin. 27. The method of claim 25, wherein the light activated polymerizabie material comprises a mixture of 2,2-bis-(4-(2-hydroxy-3-methacryloyloxypropoxy)phenyl) propane and a photoinitiation system. 28. The method of claim 25, wherein the light activated polymerizabie material comprises a one part system of triisocyanates or higher isocyanates and OH-functional acrylates or methacrylates. 29. The method of claim 14, wherein the polymerizabie material is a heat activated polymerizabie material. 30. The method of claim 14, wherein the polymerizabie material is a water activated polymerizabie material. 31. The method of claim 30, wherein the water activated polymerizabie material is a siloxane with a functional group that allows polymerization of the siloxane with water. 32. The method of claim 31, wherein the water activated siloxane has alkoxy, acyloxy, acetoxy, amido, oximo, or amino functional groups. 33. The method of claim 30, wherein the water activated polymerizabie material is a polyfunctional isocyanate based polymerizabie material. 34. The method of claim 14, wherein the polymerizabie material is self-curable.