One-step processing of hydrogels for mechanically robust and chemically desired features
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61K-031/738
A61K-031/7008
A61K-031/734
출원번호
US-0269366
(2011-10-07)
등록번호
US-8946194
(2015-02-03)
발명자
/ 주소
Mayes, Sarah
Schmidt, Christine E.
출원인 / 주소
Board of Regents, University of Texas System
대리인 / 주소
Trop, Pruner & Hu, P.C.
인용정보
피인용 횟수 :
1인용 특허 :
83
초록▼
The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates
The application of a highly controlled, micron-sized, branched, porous architecture to enhance the handling properties and degradation rate of hydrogels is described in the instant invention. A previously described pattern created through one-step nucleated crystallization in a hydrogel film creates tunable mechanical properties and/or chemical stability for use in tissue engineering applications. The bulk mechanical properties and the degradation rate of the material can be tuned easily by the addition or subtraction of crystalline structure or by the addition and subtraction of backfill material, making this useful for a variety of applications. Relevant mechanical properties that can be tuned through the application of this unique porosity are moduli, elasticity, tensile strength, and compression strength. The method of the present invention can be applied to biopolymers and natural materials as well as synthetic materials.
대표청구항▼
1. An apparatus comprising: uncrosslinked hyaluronic acid included in a hydrogel film; andcrosslinked alginate included in the hydrogel;wherein (a) the alginate is crosslinked with calcium, (b) the alginate is crosslinked around the uncrosslinked hyaluronic acid, (c) the hyaluronic acid and the algi
1. An apparatus comprising: uncrosslinked hyaluronic acid included in a hydrogel film; andcrosslinked alginate included in the hydrogel;wherein (a) the alginate is crosslinked with calcium, (b) the alginate is crosslinked around the uncrosslinked hyaluronic acid, (c) the hyaluronic acid and the alginate are formed around a network of pores that are backfilled with a backfill material; and (d) the apparatus is included in a kit comprising a chemical component that dissolves the backfill material. 2. The apparatus of claim 1, wherein the network is branched. 3. The apparatus of claim 1, wherein the backfill material includes at least one of hyaluronic acid and alginate. 4. The apparatus of claim 1, wherein the backfill material is bound to at least one of the hyaluronic acid and the alginate. 5. The apparatus of claim 1, wherein degradation rate of the hydrogel is based on the backfill material. 6. The apparatus of claim 5, wherein mechanical properties of the hydrogel are based on the backfill material, the mechanical properties selected from the group consisting of moduli, elasticity, tensile strength, and compression strength. 7. The apparatus of claim 1, wherein the hydrogel encapsulates at least one of a drug, growth factor, hormone, protein, and combinations thereof. 8. The apparatus of claim 1, wherein the hydrogel includes at least one of a drug, growth factor, hormone, protein, and combinations thereof. 9. The apparatus of claim 1, wherein the network is a crystal templated network. 10. The apparatus of claim 9, wherein the network includes a crystal. 11. The apparatus of claim 1, wherein the backfill material is bound to at least itself. 12. The apparatus of claim 1, wherein the kit comprises a calcium chelator. 13. The apparatus of claim 1, wherein water has been at least partially removed from the hydrogel film. 14. An apparatus comprising: a hydrogel film having first and second opposing ends;uncrosslinked hyaluronic acid included in the hydrogel;crosslinked alginate included in the hydrogel;extending within the hydrogel;wherein (a) the alginate is crosslinked with calcium, (b) the alginate is crosslinked around the uncrosslinked hyaluronic acid, (c) the pores are backfilled with a backfill material, and (d) the backfill material is bound to at least one of the hyaluronic acid and the alginate. 15. The apparatus of claim 14, wherein the backfill material includes at least one of hyaluronic acid and alginate. 16. The apparatus of claim 14, wherein the backfill material is bound to at least itself. 17. The apparatus of claim 14, wherein the degradation rate of the hydrogel is based on the backfill material. 18. The apparatus of claim 14, wherein the mechanical properties of the hydrogel are based on the backfill material, the mechanical properties selected from the group consisting of moduli, elasticity, tensile strength, and compressive strength and the backfill material bound to at least one of the hyaluronic acid and the alginate includes the backfill material being at least one of (i) cross-linked to at least one of the hyaluronic acid and the alginate, and (ii) covalently bound to at least one of the hyaluronic acid and the alginate. 19. The apparatus of claim 14, wherein the backfill material includes at least one of a drug, growth factor, hormone, peptide, protein, and combinations thereof. 20. The apparatus of claim 14 included in a kit comprising a calcium chelator. 21. The apparatus of claim 14 included in a kit comprising a chemical component that dissolves the backfill material. 22. The apparatus of claim 14, wherein water has been at least partially removed from the hydrogel film. 23. An apparatus comprising: uncrosslinked hyaluronic acid included in a hydrogel film; andcrosslinked alginate included in the hydrogel;wherein (a) the alginate is crosslinked with calcium, (b) the alginate is crosslinked around the uncrosslinked hyaluronic acid, (c) the hyaluronic acid and the alginate are formed around a network of pores that are backfilled with a backfill material; and (d) the backfill material includes at least one of hyaluronic acid and alginate. 24. The apparatus of claim 23, wherein the backfill material is bound to at least one of the hyaluronic acid and the alginate. 25. The apparatus of claim 23, wherein degradation rate of the hydrogel is based on the backfill material. 26. The apparatus of claim 25, wherein mechanical properties of the hydrogel are based on the backfill material, the mechanical properties selected from the group consisting of moduli, elasticity, tensile strength, and compression strength. 27. The apparatus of claim 23, wherein the hydrogel encapsulates at least one of a drug, growth factor, hormone, protein, and combinations thereof. 28. The apparatus of claim 23, wherein the hydrogel includes at least one of a drug, growth factor, hormone, protein, and combinations thereof. 29. The apparatus of claim 23, wherein the network is a crystal templated network. 30. The apparatus of claim 29, wherein the network includes a crystal. 31. The apparatus of claim 23, wherein the backfill material is bound to at least itself. 32. The apparatus of claim 23 included in a kit comprising a calcium chelator. 33. The apparatus of claim 23 included in a kit comprising a chemical component that dissolves the backfill material. 34. The apparatus of claim 23, wherein water has been at least partially removed from the hydrogel film. 35. The apparatus of claim 23, wherein the backfill material includes at least one of a drug, growth factor, hormone, peptide, protein, and combinations thereof.
Sadozai, Khalid K.; Kuo, Jing-wen; Sherwood, Charles H., Bioabsorbable composites of derivatized hyaluronic acid and other biodegradable, biocompatible polymers.
Tomalia Donald A. ; Baker James R. ; Cheng Roberta C. ; Bielinska Anna U. ; Fazio Michael J. ; Hedstrand David M. ; Johnson Jennifer A. ; Kaplan ; deceased Donald A. ; Klakamp Scott L. ; Kruper ; Jr., Bioactive and/or targeted dendrimer conjugates.
Schwartz Herbert E. ; Blackmore John M., Bioresorbable compositions of carboxypolysaccharide polyether intermacromolecular complexes and methods for their use in reducing surgical adhesions.
Drohan William N. ; MacPhee Martin J. ; Miekka Shirley I. ; Singh Manish S. ; Elson Clive,CAX ; Taylor ; Jr. John R., Chitin hydrogels, methods of their production and use.
Schwartz, Herbert E.; Blackmore, John M.; Cortese, Stephanie M.; Oppelt, William G., Compositions of polyacids and polyethers and methods for their use in reducing adhesions.
Lebreton, Pierre, Cross-linking of low and high molecular weight polysaccharides preparation of injectable monophase hydrogels and polysaccharides and hydrogels thus obtained.
Aeschlimann, Daniel; Bulpitt, Paul, Functionalized derivatives of hyaluronic acid, formation of hydrogels in situ using same, and methods for making and using same.
Park Kinam ; Chen Jun ; Park Haesun, Hydrogel composites and superporous hydrogel composites having fast swelling, high mechanical strength, and superabsorbent properties.
Omidian, Hossein; Qiu, Yong; Yang, Shicheng; Kim, Dukjoon; Park, Haesun; Park, Kinam, Hydrogels having enhanced elasticity and mechanical strength properties.
Yin Rui ; Tomalia Donald A. ; Hedstrand David M. ; Swanson Douglas R. ; Baker ; Jr. James R. ; Kukowska-Latallo Jolanta F., Hyper comb-branched polymer conjugates.
Sheng Ping Zhong ; Arthur R. Madenjian ; Douglas E. Godshall ; John M. Ronan ; Samuel A. Thompson, Medical devices comprising hydrogel polymers having improved mechanical properties.
John M. Ronan ; Samuel A. Thompson, Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties.
Ronan John M. ; Thompson Samuel A., Medical devices comprising ionically and non-ionically crosslinked polymer hydrogels having improved mechanical properties.
Miller, Mark E.; Cortese, Stephanie M.; Schwartz, Herbert E.; Oppelt, William G., Polyacid/polyalkylene oxide foams and gels and methods for their delivery.
DeLuca Patrick P. (Lexington KY) Kanke Motoko (Fukuyama JPX) Sato Toyomi (Tokyo CA JPX) Schroeder Hans G. (Encinitas CA), Porous microspheres for drug delivery and methods for making same.
McDonnell, Peter D.; Rea, Gary S.; Thomas, Peter W.; Larrousse, Mark F.; Bodmer, Jr., Richard V., Process for purification and drying of polymer hydrogels.
Richard D Antanavich ; Randel Dorian, RETRIEVABLE BIOARTIFICIAL IMPLANTS HAVING DIMENSIONS ALLOWING RAPID DIFFUSION OF OXYGEN AND RAPID BIOLOGICAL RESPONSE TO PHYSIOLOGICAL CHANGE, PROCESSES FOR THEIR MANUFACTURE, AND METHODS FOR THEIR U.
Hamilton Raymond (Somerville MA) Fox Ellen M. (Cranston RI) Acharya Raksha A. (Northboro MA) Walts Alan E. (Brookline MA), Water insoluble derivatives of hyaluronic acid.
Hähnle, Hans-Joachim; Schröder, Ulrich; Heider, Wolfgang; Schornick, Gunnar; Anstock, Thomas, Water-absorbing, cellular, cross-linked polymers with improved distribution effect, method for their production and their use.
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