[특허]Flow cell assembly for liquid sample analyzer

PerkinElmer Health Sciences, Inc.

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특허 상세정보

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Flow cell assembly for liquid sample analyzer

특허상세정보
국가/구분	United States(US) Patent 등록
국제특허분류(IPC7판)	G01N-033/36 G01N-021/05 G01N-021/03 G01N-021/25 G01N-030/74
미국특허분류(USC)	356/246;
출원번호	US-0281351 (2014-05-19)
등록번호	US-8947654 (2015-02-03)
발명자 / 주소	Hanlon, Gregory Neal, Timothy Edwards, Richard DiCesare, Joseph L. Aikens, David M.
출원인 / 주소	PerkinElmer Health Sciences, Inc.
대리인 / 주소	Myers Bigel Sibley & Sajovec, PA
인용정보	피인용 횟수 : 0 인용 특허 : 21

초록
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A flow cell assembly for use in a liquid sample analyzer including a radiation source, a sensing device and a liquid sample source to supply a liquid sample includes an entrance joint member, a liquid core waveguide, a liquid sample feed tube, and an input optical fiber. The entrance joint member includes a waveguide receiving bore and a feed tube receiving bore. The liquid core waveguide is mounted in the waveguide receiving bore and defines a waveguide bore. The liquid sample feed tube is mounted in the feed tube receiving bore such that the liquid sample feed tube is in fluid communication with the waveguide bore to fluidly connect the liquid sample source to the waveguide bore. The input optical fiber is mounted in the entrance joint member to transmit radiation from the radiation source to the waveguide bore, which radiation is transmitted through the waveguide bore and the liquid sample therein to the sensing device.

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청구항
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1. A flow cell assembly for use in a liquid sample analyzer, the liquid sample analyzer including a radiation source, a sensing device and a liquid sample source to supply a liquid sample, the flow cell assembly comprising: a joint member including an axially extending alignment bore, the alignment bore including a waveguide receiving bore section and an optical fiber termination receiving bore section;a liquid core waveguide mounted in the waveguide receiving bore section, the liquid core waveguide defining a waveguide bore; andan optical fiber assembly including an optical fiber and an optical fiber termination mounted on an end of the optical fiber, wherein the end of the optical fiber and the optical fiber termination are mounted in the optical fiber termination receiving bore section, the optical fiber having an exposed optical fiber end face adjacent the optical fiber termination;wherein the alignment bore radially aligns the liquid core waveguide with the optical fiber termination and thereby radially aligns the optical fiber end face with the waveguide bore; andwherein the optical fiber is operative to transmit radiation from the radiation source to the waveguide bore, which radiation is transmitted through the waveguide bore and the liquid sample therein to the sensing device; andwherein:the alignment bore further includes an interface bore section axially interposed between the waveguide receiving bore section and the optical fiber termination receiving bore section;an end portion of the liquid core waveguide and an opposing end portion of the optical fiber termination are each disposed in the interface bore section; andthe interface bore section radially aligns the end portion of the liquid core waveguide with the opposing end portion of the optical fiber termination and thereby radially aligns the optical fiber end face with the waveguide bore. 2. The flow cell assembly of claim 1 wherein: the joint member is unitary and includes a feed tube receiving bore;the flow cell assembly includes a liquid sample feed tube mounted in the feed tube receiving bore such that the liquid sample feed tube is in fluid communication with the waveguide bore to fluidly connect the liquid sample source to the waveguide bore. 3. The flow cell assembly of claim 2 wherein: the waveguide bore defines a longitudinally extending waveguide bore axis; andthe feed tube receiving bore extends radially with respect to the waveguide bore axis. 4. The flow cell assembly of claim 2 wherein: the feed tube receiving bore includes a feed tube engaging section and a counterbore section;the feed tube engaging section forms as interference fit with the liquid sample feed tube; andthe flow cell assembly further includes an adhesive in the counterbore section bonding the liquid sample feed tube to the counterbore section. 5. The flow cell assembly of claim 2 wherein the liquid core waveguide includes: an outer waveguide body defining a waveguide body bore; anda cladding layer mounted in the waveguide body bore and defining the waveguide bore;wherein the cladding layer is formed of a material having a lower refractive index than the liquid sample. 6. The flow cell assembly of claim 2 including: an exit joint member including a waveguide receiving bore and an exit tube receiving bore, wherein the liquid core waveguide is also mounted in the waveguide receiving bore of the exit joint member;a liquid sample exit tube mounted in the exit tube receiving bore such that the liquid sample exit tube is in fluid communication with the waveguide bore to fluidly connect the waveguide bore to a liquid sample receiver; andan output optical fiber mounted in the exit joint member to transmit radiation from the waveguide bore to the sensing device. 7. The flow cell assembly of claim 1 including a mask member disposed in the interface bore section between the liquid core waveguide and the optical fiber termination, the mask member defining an aperture to permit transmission of light from the optical fiber end face through the aperture into the waveguide bore. 8. The flow cell assembly of claim 1 wherein the liquid core waveguide is fluidly sealed in the alignment bore. 9. The flow cell assembly of claim 1 wherein the interface bore section coaxially aligns the optical fiber and the waveguide bore. 10. The flow cell assembly of claim 1 wherein the optical fiber termination is a ferrule. 11. The flow cell assembly of claim 10 wherein: the ferrule is secured to the end of the optical fiber by adhesive; andthe ferrule has an end face and the end face of the optical fiber is substantially flush with the end face of the ferrule. 12. The flow cell assembly of claim 1 wherein: a liquid core waveguide includes a cladding layer formed of a material having a lower refractive index than the liquid sample, wherein the cladding layer defines:the waveguide bore, wherein the waveguide bore extends axially and has a bore input end and a bore output end;an input opening at the bore input end; anda liquid sample feed slot extending radially through the cladding layer and intersecting each of the waveguide bore and the input opening;wherein the flow cell assembly is configured to feed a flow of the liquid sample into the waveguide bore through the liquid sample feed slot. 13. The flow cell assembly of claim 12 wherein: the cladding layer defines an exit end opening at the output bore end;the cladding layer further defines a liquid sample exit slot extending radially through the cladding layer and intersecting each of the waveguide bore and the output opening; andthe flow cell assembly is configured to remove the flow of the liquid sample from the waveguide bore through the liquid sample exit slot. 14. The flow cell assembly of claim 13 wherein the cladding layer is a tubular sleeve terminating at the input and output bore ends and the waveguide bore has a substantially uniform diameter from the first bore end to the second bore end. 15. The flow cell assembly of claim 1 wherein the end portion of the liquid core waveguide and the opposing end portion of the optical fiber termination each engage the joint member in the interface bore section to positively concentrically align the optical fiber end face with the waveguide bore. 16. The flow cell assembly of claim 1 wherein a diameter of the interface bore section is less than a diameter of the waveguide receiving bore section and a diameter of the optical fiber termination receiving bore section. 17. The flow cell assembly of claim 1 wherein the end face of the optical fiber is located in the interface bore section. 18. The flow cell assembly of claim 1 wherein the optical fiber termination is secured to the end of the optical fiber by adhesive. 19. The flow cell assembly of claim 1 wherein the optical fiber termination has an end face and the end face of the optical fiber is substantially flush with the end face of the optical fiber termination. 20. The flow cell assembly of claim 1 wherein the end face of the optical fiber is located adjacent and outside of the waveguide bore. 21. The flow cell assembly of claim 20 wherein the end face of the optical fiber defines a portion of a flow path of the liquid sample entering or exiting the waveguide bore. 22. The flow cell assembly of claim 1 wherein the optical fiber termination is secured in the optical fiber termination receiving bore section by at least one of an interference fit, epoxy and an interlock between cooperating interlock features on the optical fiber termination and the joint member in the optical fiber termination receiving bore section. 23. The flow cell assembly of claim 1 including a spring biasing the joint member and the liquid core waveguide against one another.

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Flow cell assembly for liquid sample analyzer

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Flow cell assembly for liquid sample analyzer

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