Methods of treating malnutrition are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal
Methods of treating malnutrition are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.
대표청구항▼
1. A method of treating a gastrointestinal spasm associated with malnutrition in a subject, the method comprising: administering an effective amount of a formulation to a subject having malnutrition with an associated gastrointestinal spasm, the formulation having a water soluble tannin combined wit
1. A method of treating a gastrointestinal spasm associated with malnutrition in a subject, the method comprising: administering an effective amount of a formulation to a subject having malnutrition with an associated gastrointestinal spasm, the formulation having a water soluble tannin combined with hydrogen peroxide in a pharmaceutically acceptable excipient;wherein,the tannin has a molecular weight ranging from about 170 Daltons to about 4000 Daltons;the tannin:peroxide weight ratio ranges from about 1:1000 to about 10:1; and,the formulation relieves the malnutrition in the subject by relieving the associated gastrointestinal spasm when compared to a second subject in a control group also having malnutrition with an associated gastrointestinal spasm in which the formulation was not administered. 2. The method of claim 1, further comprising adding a nutritional supplement selected from the group consisting of sodium, potassium, dextrose, fructose, glucose, magnesium, zinc, selenium, Vitamin A, Vitamin D, Vitamin C, dietary fiber, and combinations thereof. 3. The method of claim 1, wherein the tannin is a hydrolysable tannin. 4. The method of claim 1, wherein the tannin is a water soluble condensed tannin. 5. The method of claim 1, wherein the tannin is a mixture of a hydrolysable tannin and a water soluble condensed tannin. 6. The method of claim 1, wherein the tannin is a flavanol. 7. The method of claim 1, wherein the tannin is a catechin. 8. The method of claim 1, wherein the tannin is gallic acid, epigallic acid, or a combination thereof. 9. The method of claim 1, wherein the tannin is a gallotannin. 10. The method of claim 1, wherein the tannin is an ellagitannin. 11. The method of claim 1, wherein the tannin is a punicalagin. 12. The method of claim 1, wherein the tannin is combined with the hydrogen peroxide as a component of a water extract of a plant tissue. 13. The method of claim 1, wherein the tannin is combined with the hydrogen peroxide as a component of an alcohol extract of a plant tissue. 14. The method of claim 3, wherein the hydrolysable tannin is a product of a water extraction of Chinese gall. 15. The method of claim 4, wherein the water soluble condensed tannin is a product of a water extraction of green tea leaves. 16. The method of claim 1, wherein the tannin is a hydrolysable tannin having from 3-12 galloyl residues. 17. A method of treating a gastrointestinal spasm associated with malnutrition in a subject, comprising: administering an effective amount of a formulation to a subject having malnutrition with an associated gastrointestinal spasm, the formulation produced from a process includingcombining a water soluble tannin with hydrogen peroxide at a tannin:peroxide weight ratio that ranges from about 1:1000 to about 10:1, the tannin having a molecular weight ranging from about 170 Daltons to about 4000 Daltons;removing free hydrogen peroxide from the combination; and,mixing the combination of the tannin and the hydrogen peroxide with a pharmaceutically acceptable excipient to create the formulation;wherein,the administering includes selecting a desired concentration of the formulation for the administering; and,the formulation relieves the malnutrition in the subject by relieving the associated gastrointestinal spasm when compared to a second subject in a control group also having malnutrition with an associated gastrointestinal spasm in which the formulation was not administered. 18. The method of claim 17, further comprising adding a nutritional supplement selected from the group consisting of sodium, potassium, dextrose, fructose, glucose, magnesium, zinc, selenium, Vitamin A, Vitamin D, Vitamin C, dietary fiber, and combinations thereof. 19. The method of claim 17, wherein the tannin is a hydrolysable tannin. 20. The method of claim 17, wherein the tannin is a water soluble condensed tannin. 21. The method of claim 17, wherein the tannin is a mixture of a hydrolysable tannin and a water soluble condensed tannin. 22. The method of claim 17, wherein the tannin is a flavanol. 23. The method of claim 17, wherein the tannin is a catechin. 24. The method of claim 17, wherein the tannin is gallic acid, epigallic acid, or a combination thereof. 25. The method of claim 17, wherein the tannin is a gallotannin. 26. The method of claim 17, wherein the tannin is an ellagitannin. 27. The method of claim 17, wherein the tannin is a punicalagin. 28. The method of claim 17, wherein the tannin is combined with the hydrogen peroxide as a component of a water extract of a plant tissue. 29. The method of claim 17, wherein the tannin is combined with the hydrogen peroxide as a component of an alcohol extract of a plant tissue. 30. A method of treating gastrointestinal spasm associated with malnutrition in a subject, comprising: concurrently administering a combination of(i) an effective amount of a composition to a subject having malnutrition with an associated gastrointestinal spasm, the composition produced from a process includingcombining a water soluble, hydrolysable tannin with hydrogen peroxide at a tannin:peroxide weight ratio that ranges from about 1:1000 to about 10:1, the tannin having a molecular weight ranging from about 170 Daltons to about 4000 Daltons;and,(ii) an effective amount of a nutritional supplement selected from the group consisting of sodium, potassium, dextrose, fructose, glucose, magnesium, zinc, selenium, Vitamin A, Vitamin D, Vitamin C, dietary fiber, and combinations thereof;wherein,the administering includes selecting a desired concentration of the formulation for the administering; and,the formulation relieves the malnutrition in the subject by relieving the associated gastrointestinal spasm when compared to a baseline health of the subject. 31. The method of claim 30, wherein the water soluble tannin is a gallotannin or an ellagitannin, and the mixing further comprises removing free hydrogen peroxide from the combination; and, mixing the combination of the tannin and the hydrogen peroxide with a pharmaceutically acceptable excipient to create the formulation. 32. The method of claim 30, wherein the tannin is an ellagitannin. 33. The method of claim 30, wherein the tannin is a punicalagin.
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