Device and method for delivering an oral care agent
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61Q-011/00
A61C-005/00
A61K-006/00
A61K-008/00
A61K-008/22
A61C-019/06
A61C-019/08
출원번호
US-0187666
(2002-07-02)
등록번호
US-8956160
(2015-02-17)
발명자
/ 주소
Willison, Michael P.
Townshend, Joseph C.
Bryan, Christopher D.
Beskar, Emilie S.
Mudumba, Sreenivasu
Faasse, Adrian
Lai, Janet
출원인 / 주소
Ranir, LLC
대리인 / 주소
Warner Norcross & Judd LLP
인용정보
피인용 횟수 :
0인용 특허 :
51
초록▼
An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an anchor layer overtop the backing layer, and an oral care layer overtop the anchor layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The o
An oral care agent delivery device is provided which comprises a permanently deformable backing layer, an anchor layer overtop the backing layer, and an oral care layer overtop the anchor layer. The device is sized to fit over a plurality of teeth in an upper or lower dental arch of a subject. The oral care layer comprises at least one oral care agent and at least one hydrophilic polymer. The oral care layer is in contact with the anchor layer and forms an adhesive bond with the anchor layer; however, the oral care layer is minimally invested in the anchoring layer. When hydrated, the oral care layer has an adhesiveness relative to the surface of a user's teeth that is sufficient to retain the device on the user's teeth when placed thereon. The device can also have an oral care agent which is activated on hydration of the oral care layer, or an oral care layer which releases the oral care agent over time.
대표청구항▼
1. A device for delivering an oral care agent, wherein the device is sized to fit over a plurality of teeth in an upper or lower dental arch in a subject, comprising: a permanently deformable backing layer;an anchor layer comprising a layer of an open-cell foam, the anchor layer having a first side
1. A device for delivering an oral care agent, wherein the device is sized to fit over a plurality of teeth in an upper or lower dental arch in a subject, comprising: a permanently deformable backing layer;an anchor layer comprising a layer of an open-cell foam, the anchor layer having a first side and second side opposite said fist side, the first side in contact with the backing layer; and the backing layer penetrating into the first side of the anchor layer andan oral care layer comprising at least one oral care agent and at least one hydrophilic polymer, wherein the oral care layer is in contact with the second side of the anchor layer and forms an adhesive bond thereto,and wherein the oral care layer is minimally invested in the anchor layer and has an adhesiveness when hydrated relative to the surface of a the teeth of user that is sufficient to retain the device on the user's teeth when placed thereon. 2. The device of claim 1, wherein the backing layer is from about 0.025 mm to about 2 mm thick. 3. The device of claim 1, wherein the backing layer is from about 0.125 to about 0.8 thick. 4. The device of claim 1, wherein the backing layer is about 0.75 mm thick. 5. The device of claim 1, wherein the backing layer comprises a non-polymeric material. 6. The device of claim 1, wherein the non-polymeric material comprises a wax, a resin, or mixtures thereof. 7. The device of claim 6, wherein the wax is selected from the group consisting of a microcrystalline wax; a paraffin wax; a synthetic paraffin wax; and mixtures thereof. 8. The device of claim 6, wherein the resin is a hydrocarbon resin. 9. The device of claim 8, wherein the hydrocarbon resin is a water-white, clear cycloaliphatic hydrocarbon resin. 10. The device of claim 1 wherein the backing layer is colored. 11. The device of claim 10 wherein the backing layer is colored with at least one colorizing compound. 12. The device of claim 11 wherein the at least one colorizing compound is selected from the group consisting of FD&C Red No. 3; Food Red 17; Food Yellow 13; FD&C Yellow No. 5; FD&C Yellow No. 6; FD&C Green No. 3; FD&C Blue No. 1; FD&C Blue No. 2; FD&C Red No. 40; Orange B; Citrus Red No. 2; and combinations thereof. 13. The device of claim 11 wherein the at least one colorizing compound is selected from the group consisting of annatto extract; beta-apo-8′-carotenal; beta-carotene; beet powder; canthaxanthin; caramel color; carrot oil; cochineal extract (carmine); toasted, partially defatted, cooked cottonseed flour; ferrous gluconate; fruit juice; grape color extract; grape skin extract (enocianina); paprika; paprika oleoresin; riboflavin; saffron; turmeric; turmeric oleoresin; vegetable juice; and combinations thereof. 14. The device of claim 12 wherein the at least one colorizing compound is selected from the group consisting of titanium dioxide; chromium oxide greens; ultramarine blues and pinks; and ferric oxides. 15. The device of claim 11, wherein the dye comprises a dye-lake form. 16. The device of claim 15, wherein the dye-lake form is selected from the group consisting of FD&C Green #1 lake; FD&C Blue #2 lake; FD&C R&D #30 lake; and FD&C Yellow #15 lake. 17. The device of claim 11, wherein the at least one colorizing compound comprises about 0.05% to about 10% by weight of the backing layer. 18. The device of claim 17, wherein the at least one colorizing compound comprises about 0.1% to about 5% by weight of the backing layer. 19. The device of claim 11, wherein the backing layer comprises multiple colors. 20. The device of claim 19, wherein the multiple colors comprise a pattern. 21. The device of claim 11, wherein the backing layer further comprises glitter particles. 22. The device of claim 1, wherein the backing layer is embedded or decorated with decorative items. 23. The device of claim 11, wherein the backing layer is embedded or decorated with decorative items. 24. The device of claim 1, wherein the backing layer displays letters, words, or images. 25. The device of claim 11, wherein the backing layer displays letters, words, or images. 26. The device of claim 1, wherein the open-cell foam comprises a polyurethane, polystyrene or polyethylene foam. 27. The device of claim 26, wherein the open-cell foam comprises an ether based reticulated polyurethane foam. 28. The device of claim 1, wherein the anchor layer is from about 0.025 mm to about 1 mm thick. 29. The device of claim 28, wherein the anchor layer is about 0.6 mm to about 0.8 mm thick. 30. The device of claim 1, wherein the anchor layer is colored. 31. The device of claim 30 wherein the anchor layer is colored with at least one colorizing compound. 32. The device of claim 31 wherein the at least one colorizing compound is selected from the group consisting of FD&C Red No. 3; Food Red 17; Food Yellow 13; FD&C Yellow No. 5; FD&C Yellow No. 6; FD&C Green No. 3; FD&C Blue No. 1; FD&C Blue No. 2; FD&C Red No. 40; Orange B; Citrus Red No. 2; and combinations thereof. 33. The device of claim 31 wherein the at least one colorizing compound is selected from the group consisting of annatto extract; beta-apo-8′-carotenal; beta-carotene; beet powder; canthaxanthin; caramel color; carrot oil; cochineal extract (carmine); toasted, partially defatted, cooked cottonseed flour; ferrous gluconate; fruit juice; grape color extract; grape skin extract (enocianina); paprika; paprika oleoresin; riboflavin; saffron; turmeric; turmeric oleoresin; vegetable juice; and combinations thereof. 34. The device of claim 31 wherein the at least one colorizing compound is selected from the group consisting of titanium dioxide; chromium oxide greens; ultramarine blues and pinks; and ferric oxides. 35. The device of claim 31, wherein the dye comprises a dye-lake form. 36. The device of claim 35, wherein the dye-lake form is selected from the group consisting of FD&C Green #1 lake; FD&C Blue #2 lake; FD&C R&D #30 lake; and FD&C Yellow #15 lake. 37. The device of claim 31, wherein the colorizing compound comprises about 0.05 percent to about 10 percent by weight of the anchor layer. 38. The device of claim 37, wherein the colorizing compound comprises about 0.1 percent to about 5 percent by weight of the anchor layer. 39. The device of claim 31, wherein the anchor layer comprises multiple colors. 40. The device of claim 1, wherein the oral care layer is from about 0.025 mm to about 4 mm thick. 41. The device of claim 40, wherein the oral care layer is from about 0.125 mm to about 1.5 mm thick. 42. The device of claim 41, wherein the oral care layer is from about 0.25 mm to about 1.0 mm thick. 43. The device of claim 42, wherein the oral care layer is about 0.3 mm thick. 44. The device of claim 1, wherein the adhesiveness of the oral care layer with respect to the surface of the user's teeth is from about 200 N/m to about 400 N/m. 45. The device of claim 1, wherein the at least one oral care agent is entrapped within the oral care layer. 46. The device of claim 45, wherein the at least one oral care agent is released from the hydrophilic polymer upon hydration of the oral care layer. 47. The device of claim 1, wherein the at least one oral care agent is activated upon hydration of the oral care layer. 48. The device of claim 1 wherein the oral care layer comprises a pressure-sensitive adhesive comprising at least one oral care agent, at least one hydrophilic polymer, and at least one water-soluble plasticizer that is miscible with the hydrophilic polymer. 49. The device of claim 48 wherein the at least one hydrophilic polymer has a hydrophilicity as measured by water uptake of greater than about 25%. 50. The device of claim 49 wherein the at least one hydrophilic polymer has a glass transition temperature T(g) or melting point T(m) higher than about 25° C. and lower than about 120° C. 51. The device of claim 50, wherein the at least one hydrophilic polymer has a glass transition temperature T(g) or melting point T(m) higher than about 30° C. and lower than about 100° C. 52. The device of claim 48 wherein the at least one hydrophilic polymer is selected from the group consisting of polysaccharides; water-soluble synthetic polymers; polypeptides; and natural gums. 53. The device of claim 48 wherein the at least one hydrophilic polymer is selected from the group consisting of starches and starch derivatives; polyvinyl pyrrolidone; polyvinyl alcohol; hydroxypropyl cellulose; sodium carboxymethyl cellulose; polyethylene oxide; polyacrylic acid; polyacrylates; carboxylic acid polymers; xanthan gum; karaya gum; and gelatin. 54. The device of claim 48 wherein the at least one plasticizer is liquid at room temperature and has a boiling point higher than about 80° C. 55. The device of claim 54 wherein the at least one plasticizer is selected from the group consisting of glycerins; sorbitol; glycols; polysorbate 80; triethyl titrate; acetyl triethyl titrate; and tributyl titrate. 56. The device of claim 48, wherein the oral care layer comprises at least one crosslinked or non-crosslinked polymer selected from the group consisting of 2-acrylamido-2-methyl-propanesulfonic acid; polyvinyl pyrrolidone; polyethylene oxide; acrylates; polyvinyl alcohol; and carboxylic acid polymers. 57. The device of claim 56, wherein the oral care layer comprises crosslinked or non-crosslinked 2-acrylamido-2-methyl-propanesulfonic acid. 58. The device of claim 56, wherein the oral care layer comprises crosslinked or non-crosslinked polyvinyl pyrrolidone. 59. The device of claim 1, wherein the oral care layer is a sustained release oral care layer. 60. The device of claim 48, wherein the oral care layer is a sustained release oral care layer. 61. The device of claim 58, wherein the oral care layer is a sustained release oral care layer. 62. The device of claim 61 wherein the sustained-release oral care layer releases the at least one oral care agent at a rate of approximately 0.2 mg/cm2-min to 1 mg/cm2-min. 63. The device of claim 1, wherein the amount of the at least one oral care agent in the oral care layer is about 0.01% to about 40%. 64. The device of claim 63, wherein the amount of the at least one oral care agent in the oral care layer is about 0.1% to about 20%. 65. The device of claim 64, wherein the amount of the at least, one oral care agent in the oral care layer is about 0.5% to about 10%. 66. The device of claim 65, wherein the amount of the at least one oral care agent in the oral care layer is about 1% to about 7%. 67. The device of claim 1, wherein the at least one oral care agent is a pharmaceutically active agent or a cosmetically active agent. 68. The device of claim 67, wherein the pharmaceutically active agent is selected from the group consisting of a non-steroidal anti-inflammatory/analgesic; a steroidal anti-inflammatory agent; a local anesthetic; a bactericide/disinfectant; an antibiotic; an antifungal; a tooth desensitizing agent; a fluoride anticavity/antidecay agent; an anti tartar/anti-calculus agent; an enzyme which inhibits the formation of plaque, calculus or dental caries; and a nutritional supplement for local delivery to the teeth and surrounding tissue. 69. The device of claim 68, wherein the non-steroidal anti-inflammatory/analgesic agent is selected from the group consisting of acetaminophen; methyl salicylate; monoglycol salicylate; aspirin; mefenamic acid; flufenamic acid; indomethacin; diclofenac; alclofenac; diclofenac sodium; ibuprofen; flurbiprofen; fentizac; bufexamac; piroxicam; phenylbutazone; oxyphenbutazone; clofezone; pentazocine; mepirizole; and tiaramide hydrochloride. 70. The device of claim 68, wherein the steroidal anti-inflammatory agent is selected from the group consisting of include hydrocortisone; prednisolone; dexamethasone; triamcinolone acetonide; fluocinolone acetonide; hydrocortisone acetate; prednisolone acetate; methylprednisolone; dexamethasone acetate; betamethasone; betamethasone valerate; flumetasone; flourometholone; budesonide; and beclomethasone dipropionate. 71. The device of claim 68, wherein the local anesthetic is selected from the group consisting of dibucaine hydrochloride; dibucaine; lidocaine hydrochloride; lidocaine; benzocaine; p-buthylaminobenzoic acid 2-(diethylamino)ethyl ester hydrochloride; procaine hydrochloride; tetracaine hydrochloride; chloroprocaine hydrochloride; oxyprocaine hydrochloride; mepivacaine; cocaine hydrochloride; and piperocaine hydrochloride. 72. The device of claim 68, wherein the bactericide/disinfectant is selected from the group consisting of thimerosol; phenol; thymol; benzalkonium chloride; benzethonium chloride; chlorhexidine; providone iodide; cetylpyridinium chloride; eugenol, and trimethylammonium bromide. 73. The device of claim 68, wherein the antibiotic is selected from the group consisting of penicillin; meticillin; oxacillin; cefalotin; cefaloridin; erythromycin; lincomycin; tetracycline; chlortetracycline; oxytetracycline; metacycline; chloramphenicol; kanamycin; streptomycin; gentamicin; bacitracin; and cycloserine. 74. The device of claim 68, wherein the antifungal drug is selected from the group consisting of amphotericin; clotrimazole; econazole nitrate; fluconazole; griseofulvin; itraconazole; ketoconazole; miconazole; nystatin; terbinafine hydrochloride; undecenoic acid; and zinc undecenoate. 75. The device of claim 68, wherein the tooth-desensitizing agent is selected from the group consisting of potassium nitrate and strontium chloride. 76. The device of claim 68, wherein the fluoride anticavity/antidecay agent is selected from the group consisting of sodium fluoride, potassium fluoride and ammonium fluoride. 77. The device of claim 68, wherein the anti-tartar/anti-calculus agents is selected from the group consisting of phosphates; pyrophosphates, polyphosphates, polyphosphonates; linear carboxylic acids; sodium zinc citrate; and mixtures thereof. 78. The device of claim 68, wherein the enzyme which inhibits the formation of plaque, calculus or dental caries is selected from the group consisting of proteases; lipases; dextranases, glucanohydrolases, endoglycosidases, mucinases; amylases; and mixtures thereof. 79. The device of claim 68, wherein the nutritional supplement for local delivery to the teeth and surrounding tissue is a vitamin or mineral. 80. The device of claim 79, wherein the nutritional supplement for local delivery to the teeth and surrounding tissue is a vitamin selected from the group consisting of vitamin C; vitamin D; thiamine; riboflavin; calcium pantothenate; niacin; folic acid; nicotinamide; pyridoxine; cyanocobalamin; para-aminobenzoic acid; bioflavonoids; and mixtures thereof. 81. The device of claim 79, wherein the nutritional supplement for local delivery to the teeth and surrounding tissue is a mineral selected from the group consisting of calcium; phosphorus; fluoride; zinc; manganese; potassium; and mixtures thereof. 82. The device of claim 67, wherein the cosmetically active agent is selected from the group consisting of a breath freshener; a tooth whitening agent; and a tooth coloring or tinting agent. 83. The device of claim 82, wherein the tooth whitening agent is selected from the group consisting of peroxides; metal chlorites; perborates; percarbonates; peroxyacids; and combinations thereof. 84. The device of claim 83, wherein the tooth whitening agent is a peroxide selected from the group consisting of hydrogen peroxide; calcium peroxide; carbamide peroxide; and mixtures thereof. 85. The device of claim 83, wherein the tooth whitening agent is a metal chlorite selected from the group consisting of calcium chlorite; barium chlorite; magnesium chlorite; lithium chlorite; sodium chlorite; and potassium chlorite; hypochlorite and chlorine dioxide. 86. The device of claim 83, wherein the concentration of tooth whitening agent in the oral care layer is about 0.01% to about 40%. 87. The device of claim 84, wherein the peroxide compound in the oral care layer is equivalent to about 0.1% to about 20% hydrogen peroxide. 88. The device of claim 87, wherein the peroxide compound in the oral care layer is equivalent to about 0.5% to about 10% hydrogen peroxide. 89. The device of claim 88, wherein the peroxide compound in the oral care layer is equivalent to about 1% to about 7% hydrogen peroxide. 90. The device of claim 89, wherein the peroxide compound in the oral care layer is equivalent to about 6% hydrogen peroxide. 91. The device of claim 84, wherein the amount of hydrogen peroxide in the oral care layer is from about 0.1% to about 30%. 92. The device of claim 91, wherein the amount of hydrogen peroxide in the oral care layer is from about 3% to about 20%. 93. The device of claim 92, wherein the amount of hydrogen peroxide in the oral care layer is from about 6% to about 10%. 94. The device of claim 1, wherein the oral care layer further comprises a colorizing compound; food additive; flavorant; sweetener; or preservative. 95. The device of claim 94, wherein the flavorant is selected from the group consisting of wintergreen; peppermint; spearmint; menthol; fruit flavors; vanilla; cinnamon; spices; flavor oils; oleoresins; and mixtures thereof. 96. The device of claim 94, wherein the sweetener is selected from the group consisting of sucrose; fructose; aspartame; xylitol; and saccharine. 97. a device for delivering an oral care agent, wherein the device is sized to fit over a plurality of teeth in an upper or lower dental arch in a subject, comprising: a permanently deformable backing layer,wherein the backing layer comprises 50% microcrystalline wax, 15% paraffin wax; and 35% hydrocarbon resin;an anchor layer having a first side and second side opposite said first side, the first side in contact with the backing layer the anchor layer comprises an ether based reticulated open cell polyurethane foam; andan oral care layer comprises at least one oral care agent and at least one hydrophilic polymer, wherein the oral care layer is in contact with the second side of the anchor layer and forms an adhesive bond thereto, wherein the oral care layer comprises 6% hydrogen peroxide, 58% polyvinylpyrrolidone K90, 33% polyethylene glycol 400; and 12% methacrylic acid—ethyl acrylate copolymer (1:1),and wherein the oral care layer is minimally invested in the anchor layer and has an adhesiveness when hydrates relative to the surface of the teeth of the user that is sufficient to retain the device on the user's teeth when placed thereon. 98. The device of claim 97, wherein the anchor layer is colored. 99. The device of claim 1, further comprising a release liner or covering over the oral care layer. 100. The device of claim 1, further comprising a scrim embedded in the oral care layer. 101. The device of claim 97, further comprising a scrim embedded in the oral care layer. 102. The device of claim 101, wherein the scrim comprises woven, non-woven or perforated sheetlike materials. 103. The device of claim 102, wherein the woven materials are selected from the group consisting of cotton; a polyolefin; polyester; polyurethane; polyamide; polyaramide; and glass. 104. The device of claim 102, wherein the non-woven material is selected from the group consisting of felt; a polyolefin; polyester; polyurethane; polyamide; polyaramide; and glass. 105. The device of claim 102, wherein the perforated material comprises fine pitch polypropylene net. 106. The device of claim 100, wherein the scrim comprises a non-woven polyolefin. 107. The device of claim 101, wherein the scrim comprises a non-woven polyolefin. 108. The device of claim 1 which has a “J”, “reversed J”, “V”, “U”, or “C” shape when viewed in cross-section. 109. The device of claim 1 which is sized to fit the primary, mixed or permanent dentition of a human being. 110. The device of claim 1 which is of sufficient length and width to cover the facial surface, crowns and at least partially cover the lingual surface of the incisors in an upper or lower dental arch of a human being. 111. The device of claim 1 which is of sufficient length and width to cover the facial surface, crowns and at least partially cover the lingual surface of the anterior teeth in an upper or lower dental arch of a human being. 112. The device of claim 1 which is of sufficient length and width to cover the facial surface, crowns and at least partially cover the lingual surface of the anterior and posterior teeth in an upper or lower dental arch of a human being. 113. The device of claim 1 designed to fit the upper dental arch of a human being, wherein the device is about 7 cm to about 9 cm in length, and about 0.8 cm to about 2.5 cm in width. 114. The device of claim 1 designed to fit the lower dental arch of a human being, wherein the device is about 4 cm to about 6 cm in length, and about 1 cm to about 2 cm in width. 115. The device of claim 1, wherein the device, when viewed in plan view, is bent into an essentially horseshoe shape that generally matches the catenary arch of a human being. 116. The device of claim 1 further comprising one or more notches. 117. The device of claim 1, wherein the device is substantially non-flat. 118. A method for delivering an oral care agent to the teeth in an upper or lower dental arch in a subject, which teeth are in need of treatment, comprising: 1) providing the device of claim 1;2) wetting the teeth or the oral care layer of the device;3) placing the device over the teeth of a dental arch which are in need of treatment, and4) conforming the device to the teeth and surrounding tissue by manual pressure so that the oral care layer is in contact with at least the facial surface of the teeth to be treated. 119. The method of claim 118, wherein the oral care layer comprises a pressure-sensitive adhesive comprising at least one oral care agent, at least one hydrophilic polymer, and at least one water-soluble plasticizer that is miscible with the hydrophilic polymer. 120. The method of claim 119, wherein the at least one hydrophilic polymer has a hydrophilicity as measured by water uptake of greater than about 25%. 121. The method of claim 120, wherein the at least one hydrophilic polymer has a glass transition temperature T(g) or melting point T(m) higher than about 25° C. and lower than about 120° C. 122. The method of claim 121, wherein the oral care layer comprises at least one crosslinked or non-crosslinked polymer selected from the group consisting of 2-acrylamido-2-methyl-propanesulfonic acid; polyvinyl pyrrolidone; polyethylene oxide; acrylates; polyvinyl alcohol; and carboxylic acid polymers. 123. The method of claim 122, wherein the oral care layer comprises crosslinked or non-crosslinked 2-acrylamido-2-methyl-propanesulfonic acid. 124. The method of claim 122, wherein the oral care layer comprises crosslinked or non-crosslinked polyvinyl pyrrolidone. 125. The method of claim 118, wherein the oral care layer is a sustained release oral care layer. 126. The method of claim 124, wherein the oral care layer is a sustained release oral care layer. 127. The method of claim 126, wherein the sustained-release oral care layer releases the at least one oral care agent at a rate of approximately 0.2 mg/cm2-min to 1 mg/cm2-min. 128. The method of claim 118, wherein the treatment comprises a cosmetic treatment. 129. The method of claim 118, wherein the device is left on the teeth for about 15 minutes to about 4 hours. 130. The method of claim 129, wherein the device is left on the teeth for about 30 minutes to about 1 hour. 131. A method for delivering a tooth whitening agent to the teeth in an upper or lower dental arch in a subject comprising: 1) providing the device of claim 1;2) wetting the teeth or the oral care layer of the device;3) placing the device over the teeth of a dental arch, and4) conforming the device to the teeth and surrounding tissue by manual pressure so that the oral care layer is in contact with at least the facial surface of the teeth. 132. The method of claim 131, wherein the oral care layer comprises a pressure-sensitive adhesive comprising at least one tooth whitening agent, at least one hydrophilic polymer, and at least one water-soluble plasticizer that is miscible with the hydrophilic polymer. 133. The method of claim 132, wherein the at least one hydrophilic polymer has a hydrophilicity as measured by water uptake greater than about25%. 134. The method of claim 133, wherein the at least one hydrophilic polymer has a glass transition temperature T(g) or melting point T(m) higher than about 25° C. and lower than about 120° C. 135. The method of claim 134, wherein the oral care layer comprises at least one crosslinked or non-crosslinked polymer selected from the group consisting of 2-acrylamido-2-methyl-propanesulfonic acid; polyvinyl pyrrolidone; polyethylene oxide; acrylates; polyvinyl alcohol; and carboxylic acid polymers. 136. The method of claim 135, wherein the oral care layer comprises crosslinked or non-crosslinked 2-acrylamido-2-methyl-propanesulfonic acid. 137. The method of claim 135, wherein the oral care layer comprises crosslinked or non-crosslinked polyvinyl pyrrolidone. 138. The method of claim 131, wherein the oral care layer is a sustained release oral care layer. 139. The method of claim 137, wherein the oral care layer is a sustained release oral care layer. 140. The method of claim 139, wherein the sustained-release oral care layer releases the at least one tooth whitening agent at a rate of approximately 0.2 mg/cm2-min to 1 mg/cm2-min. 141. The method of claim 131, wherein the device is left on the teeth for about 15 minutes to about 4 hours. 142. The method of claim 131, wherein the device is left on the teeth for about 30 minutes to about 1 hour. 143. The method of claim 131, wherein the tooth whitening agent is selected from the group consisting of peroxides; metal chlorites; perborates; percarbonates; peroxyacids; and combinations thereof. 144. The method of claim 143, wherein the tooth whitening agent is a peroxide selected from the group consisting of hydrogen peroxide; calcium peroxide; carbamide peroxide; and mixtures thereof. 145. The method of claim 143, wherein the tooth whitening agent is a metal chlorite selected from the group consisting of calcium chlorite; barium chlorite; magnesium chlorite; lithium chlorite; sodium chlorite; and potassium chlorite; hypochlorite and chlorine dioxide. 146. The method of claim 131, wherein the concentration of tooth whitening agent in the oral care layer is about 0.01% to about 40%. 147. The method of claim 144, wherein the peroxide compound in the oral care layer provides an amount of peroxide equivalent to about 0.1% to about 20% of hydrogen peroxide. 148. The method of claim 144, wherein the peroxide compound in the oral care layer provides an amount of peroxide equivalent to about 0.5% to about 10% of hydrogen peroxide. 149. The method of claim 144, wherein the peroxide compound in the oral care layer provides an amount of peroxide equivalent to about 1% to about 7% of hydrogen peroxide. 150. The method of claim 144, wherein the peroxide compound in the oral care layer provides an amount of peroxide equivalent to about 6% of hydrogen peroxide. 151. The method of claim 144, wherein the amount of hydrogen peroxide in the oral care layer is from about 0.1% to about 30%. 152. The method of claim 144, wherein the amount of hydrogen peroxide in the oral care layer is from about 3% to about 20%. 153. The method of claim 144, wherein the amount of hydrogen peroxide in the oral care layer is from about 6% to about 10%. 154. A method of making the device of claim 1, comprising the steps of: 1) providing a permanently deformable backing layer;2) attaching an anchor layer to the backing layer;3) extruding an oral care layer onto the anchor layer. 155. The method of claim 154, in which an aqueous solution of the oral care agent is printed onto the anchor layer prior to extruding the oral care layer onto the anchor layer. 156. The method of claim 154, further comprising placing a scrim on the anchor layer before extruding the oral care layer onto the anchor layer. 157. The method of claim 156, wherein the scrim comprises a non-woven polyolefin.
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Biegajski James E. (Foster City CA) Venkatraman Subbu S. (Palo Alto CA) Scott Ann M. (Mountain View CA), Water-soluble pressure-sensitive mucoadhesive and devices provided therewith for emplacement in a mucosa-lined body cavi.
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