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A cardiac pacing system controls the progression of a cardiac disorder such as heart failure by delivering cardiac stress augmentation pacing to create or augment regional stress in the heart according to a delivery schedule programmed for a patient. Various events associated with the patient's cond

A cardiac pacing system controls the progression of a cardiac disorder such as heart failure by delivering cardiac stress augmentation pacing to create or augment regional stress in the heart according to a delivery schedule programmed for a patient. Various events associated with the patient's conditions, activities, and other treatments may render the cardiac stress augmentation pacing risky or ineffective. The system detects such events before and during each cardiac stress augmentation pacing session and modifies the delivery schedule in response to the detection of each event to ensure patient safety and therapy efficiency.

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1. A cardiac pacing system, comprising: a pacing output circuit adapted to deliver pacing pulses; anda pacing control circuit coupled to the pacing output circuit and adapted to control the delivery of the pacing pulses, the pacing control circuit including: a memory circuit storing a delivery sched

1. A cardiac pacing system, comprising: a pacing output circuit adapted to deliver pacing pulses; anda pacing control circuit coupled to the pacing output circuit and adapted to control the delivery of the pacing pulses, the pacing control circuit including: a memory circuit storing a delivery schedule specifying timing for initiating stress augmentation pacing sessions each including a session duration during which the pacing pulses are delivered using pacing parameters selected to augment myocardial mechanical stress to a level effecting cardioprotection against myocardial injury or deterioration by increasing a degree of ventricular asynchrony; wherein the delivery schedule is programmed to specify the stress augmentation pacing sessions to be delivered on a periodic basis at a session frequency between approximately 1 and 12 sessions each day and each including alternating non-pacing and pacing periods, the non-pacing periods each having a non-pacing duration during which no pacing pulse is timed to be delivered, the pacing periods each having a specified pacing duration during which a plurality of the pacing pulses is timed to be delivered using pacing parameters selected to augment myocardial mechanical stress to the level effecting cardioprotection against myocardial injury or deterioration; an inhibitory signal input to receive an inhibitory signal indicative of detection of an event potentially reducing effectiveness of stress augmentation pacing during each of the stress augmentation pacing sessions; anda stress augmentation pacing controller coupled to the memory circuit and the inhibitory signal input, the stress augmentation pacing controller programmed to initiate each of the stress augmentation pacing sessions according to the delivery schedule if the inhibitory signal is not present at a scheduled beginning of the each of the stress augmentation pacing sessions and modify the delivery schedule by rescheduling one or more of the stress augmentation pacing sessions if the inhibitory signal is present at the scheduled beginning of the each of the stress augmentation pacing sessions. 2. The system of claim 1, comprising: one or more physiological sensors adapted to sense one or more physiological signals; andan inhibitory event detector adapted to detect inhibitory events from at least a first physiological signal of the sensed one or more physiological signals and produce the inhibitory signal in response to a detection of at least one of the inhibitory events. 3. The system of claim 2, comprising a user input receiver adapted to receive one or more user signals, and wherein the inhibitory event detector is adapted to detect inhibitory events from at least the first physiological signal and a first user signal of the user signals. 4. The system of claim 3, wherein the pacing control circuit comprises a terminating signal input to receive a terminating signal, and the stress augmentation pacing controller is programmed to terminate each of the cardiac stress augmentation pacing sessions in response to the terminating signal received during the each of the stress augmentation pacing sessions. 5. The system of claim 4, comprising a terminating event detector adapted to detect terminating events using at least one of a second physiological signal of the sensed one or more physiological signals and a second user signal of the user signals and adapted to produce the terminating signal in response to a detection of at least one of the terminating events. 6. The system of claim 5, wherein the one or more physiological sensors comprise a temperature sensor adapted to sense a body temperature, and the inhibitory event detector is adapted to produce the inhibitory signal when the sensed body temperature exceeds a specified threshold temperature. 7. The system of claim 5, wherein the one or more physiological sensors comprise a glucose sensor adapted to sense a glucose signal indicative of a blood glucose level, and the inhibitory event detector is adapted to produce the inhibitory signal when the blood glucose level exceeds a specified threshold level. 8. The system of claim 5, wherein the one or more physiological sensors comprise a cardiac sensing circuit adapted to sense one or more cardiac signals, and the terminating event detector is adapted to produce the terminating signal in response to an amplitude of an ST segment of at least one cardiac signal of the one or more cardiac signals exceeding a specified threshold amplitude. 9. The system of claim 5, wherein the one or more physiological sensors comprise a respiratory sensor adapted to sense one or more respiratory signals indicative of one or more respiratory parameter, and the terminating event detector is adapted to produce the terminating signal in response to a substantial change in the respiratory pattern as indicated by a substantial change in one or more values of the one or more respiratory parameters. 10. The system of claim 5, wherein the user input receiver is adapted to receive a drug signal indicative of an administration of a specified drug, the inhibitory event detector is adapted to produce the inhibitory signal in response to receipt of the drug signal, and the terminating event detector is adapted to produce the terminating signal in response to the drug signal. 11. The system of claim 5, wherein the user input receiver is adapted to receive a food signal indicative of a substantial food consumption, the inhibitory event detector is adapted to produce the inhibitory signal in response to the food signal, and the terminating event detector is adapted to produce the terminating signal in response to receipt of the food signal. 12. A method for operating a cardiac pacing system, comprising: determining whether an inhibitory signal is present before initiating each of stress augmentation pacing sessions according to a delivery schedule using an implantable medical device, the inhibitory signal indicative of detection of an event potentially reducing effectiveness of stress augmentation pacing during the each of stress augmentation pacing sessions, the stress augmentation pacing sessions each including a session duration during which pacing pulses are delivered from the implantable medical device using pacing parameters selected to augment myocardial mechanical stress to a level effecting cardioprotection against myocardial injury or deterioration by increasing a degree of ventricular asynchrony, the delivery schedule stored in the implantable medical device and specifying timing for initiating the stress augmentation pacing sessions; timing the stress augmentation pacing sessions to be delivered on a periodic basis at a session frequency between approximately 1 and 12 sessions each day; and timing the delivery of the pacing pulses during the each of the stress augmentation pacing sessions, including timing alternating non-pacing and pacing periods, the non-pacing periods each having a non-pacing duration during which no pacing pulse is timed to be delivered, the pacing periods each having a specified pacing duration during which a plurality of the pacing pulses is timed to be delivered using pacing parameters selected to augment rnyocardial mechanical stress to the level effecting cardioprotection against myocardial injury or deterioration; initiatingthe each of the stress augmentation pacing sessions according to the delivery schedule using the implantable medical device if the inhibitory signal is not present; andmodifying the delivery schedule by rescheduling one or more of the stress augmentation pacing sessions using the implantable medical device if the inhibitory signal is present. 13. The method of claim 12, comprising: sensing one or more physiological signals;detecting inhibitory events using at least a first physiological signal of the sensed one or more physiological signals; andproducing the inhibitory signal m response to a detection of at least one of the inhibitory events. 14. The method of claim 13, comprising: receiving user signals from a user; anddetecting the inhibitory events using at least the first physiological signal and a first user signal of the user signals. 15. The method of claim 14, comprising: detecting terminating events using at least one of a second physiological signal of the sensed one or more physiological signals and a second user signal of the user signals; andterminating the each of the cardiac stress augmentation pacing sessions in response to a detection of at least one of the terminating events during the each of the stress augmentation pacing sessions. 16. The method of claim 15, wherein sensing the one or more physiological signals comprises sensing a body temperature, and producing the inhibitory signal comprises producing the inhibitory signal when the body temperature exceeds a specified threshold temperature. 17. The method of claim 15, wherein sensing the one or more physiological signals comprises sensing a glucose signal indicative of a blood glucose level, and producing the inhibitor signal comprises producing the inhibitory signal when the blood glucose level exceeds a specified threshold level. 18. The method of claim 15, wherein sensing the one or more physiological signals comprises sensing one or more cardiac signals, and producing the terminating signal comprises producing the terminating signal in response to an amplitude of an ST segment of at least one cardiac signal of the one or more cardiac signals exceeding a specified threshold amplitude. 19. The method of claim 15, wherein sensing the one or more physiological signals comprises sensing one or more respiratory signals indicative of one or more respiratory parameter, and producing the terminating signal comprises producing the terminating signal in response to a substantial change in the respiratory pattern as indicated by a substantial change in one or more values of the one or more respiratory parameters. 20. The method of claim 15, wherein receiving the user signals comprises receiving a drug signal indicative of an administration of a specified drug, producing the inhibitory signal comprises producing the inhibitory signal in response to receipt of the drug signal, and producing the terminating signal comprises producing the terminating signal in response to receipt of the drug signal. 21. The method of claim 15, wherein receiving the user signals comprises receiving a food signal indicative of a substantial food consumption, producing the inhibitory signal comprises producing the inhibitory signal in response to receipt of the drug signal, and producing the terminating signal comprises producing the terminating signal in response to receipt of the food signal.