An ocular implant adapted to reside at least partially in a portion of Schlemm's canal of an eye. In some embodiments the implant has a body extending in a curved volume whose longitudinal axis forms an arc of a circle, and a plurality of open areas and strut areas formed in the body, the open areas
An ocular implant adapted to reside at least partially in a portion of Schlemm's canal of an eye. In some embodiments the implant has a body extending in a curved volume whose longitudinal axis forms an arc of a circle, and a plurality of open areas and strut areas formed in the body, the open areas extending over more than 50% of a surface defining the curved volume, the strut areas surrounding the open areas, the body having a diameter of between 0.005 inches and 0.04 inches. The invention also provides a method of treating glaucoma including the steps of supporting tissue forming Schlemm's canal in an eye with an implant extending at least partially in the canal along an axial length within the canal; and contacting with the implant less than 50% of the tissue forming the canal along the axial length.
대표청구항▼
1. An ocular implant adapted to reside at least partially in a portion of Schlemm's canal of a human eye, the implant comprising: a body configured to extend within Schlemm's canal in a curved volume having a large radius side and a short radius side, the body having a circumferential extent within
1. An ocular implant adapted to reside at least partially in a portion of Schlemm's canal of a human eye, the implant comprising: a body configured to extend within Schlemm's canal in a curved volume having a large radius side and a short radius side, the body having a circumferential extent within the curved volume that varies along the length of the body between sections having a lesser circumferential extent and sections having a greater circumferential extent, wherein the body defines a channel extending longitudinally through the body, the channel having a substantially open side disposed on the large radius side at one of the sections of lesser circumferential extent and an adjacent section of greater circumferential extent and a plurality of openings along the length of the body on the short radius side, the openings being in fluid communication with the channel; and,an inlet portion configured to be disposed in an anterior chamber of the eye when the body is in Schlemm's canal, the inlet portion disposed on a proximal end of the body in fluid communication with the channel, the inlet portion defining one or more openings in fluid communication with the anterior chamber of the eye. 2. The ocular implant of claim 1 wherein each section of greater circumferential extent comprises a pair of struts, the sections of greater circumferential extent being separated by the sections of lesser circumferential extent comprising spine sections, the struts and spine sections defining the channel. 3. The ocular implant of claim 2 wherein each of the plurality of openings is disposed between a pair of the struts. 4. The ocular implant of claim 1 wherein the plurality of openings are disposed generally opposite the open side of the channel. 5. The ocular implant of claim 1 wherein the plurality of openings are disposed 140°-150° from the open side of the open channel. 6. The ocular implant of claim 1 wherein the body of the implant is adapted to extend at least about 60° around a circle formed by Schlemm's canal. 7. The ocular implant of claim 1 wherein the plurality of openings and the open side of the channel extend over more than 50% of a hypothetical surface covering the body portion of the implant adapted to lie within Schlemm's canal. 8. The ocular implant of claim 1 wherein the ocular implant provides a material coverage of Schlemm's canal of less than 50% over 90% of the ocular implant's length. 9. The ocular implant of claim 1 wherein the ocular implant has a generally curved resting shape. 10. The ocular implant of claim 9 wherein the resting shape forms an arc of a circle, the inlet portion lying along the arc. 11. An ocular implant adapted to reside at least partially in a portion of Schlemm's canal of a human eye, the implant comprising: a body configured to extend within Schlemm's canal in a curved volume having a large radius side and a short radius side, the body having a circumferential extent within the curved volume that varies along the length of the body between sections having a lesser circumferential extent and sections having a greater circumferential extent, wherein the body defines a channel extending longitudinally through the body, the channel having a substantially open side disposed on the large radius side at one of the sections of lesser circumferential extent and an adjacent section of greater circumferential extent and a plurality of openings along the length of the body on the short radius side, the openings being in fluid communication with the channel; and,an inlet portion configured to be disposed in an anterior chamber of the eye when the body is in Schlemm's canal, the inlet portion disposed on a proximal end of the body in fluid communication with the channel, the inlet portion defining one or more openings having a total cross sectional area greater than the cross sectional area defined by the channel in fluid communication with the anterior chamber of the eye. 12. The ocular implant of claim 11 wherein each section of greater circumferential extent comprises a pair of struts, the sections of greater circumferential extent being separated by the sections of lesser circumferential extent comprising spine sections, the struts and spine sections defining the channel. 13. The ocular implant of claim 12 wherein each of the plurality of openings is disposed between a pair of the struts. 14. The ocular implant of claim 11 wherein the plurality of openings are disposed generally opposite the open side of the channel. 15. The ocular implant of claim 11 wherein the plurality of openings are disposed 140°-150° from the open side of the open channel. 16. The ocular implant of claim 11 wherein the body of the implant is adapted to extend at least about 60° around a circle formed by Schlemm's canal. 17. The ocular implant of claim 11 wherein the plurality of openings and the open side of the channel extend over more than 50% of a hypothetical surface covering the body portion of the implant adapted to lie within Schlemm's canal. 18. The ocular implant of claim 11 wherein the ocular implant provides a material coverage of Schlemm's canal of less than 50% over 90% of the ocular implant's length. 19. The ocular implant of claim 11 wherein the ocular implant has a generally curved resting shape. 20. The ocular implant of claim 19 wherein the resting shape forms an arc of a circle, the inlet portion lying along the arc. 21. An ocular implant adapted to reside at least partially in a portion of Schlemm's canal of a human eye, the implant comprising: a body configured to extend within Schlemm's canal in a curved volume having a large radius side and a short radius side, the body having a circumferential extent within the curved volume that varies along the length of the body between sections having a lesser circumferential extent and sections having a greater circumferential extent, wherein the body defines a channel extending longitudinally through the body, the channel having a substantially open side disposed on the large radius side at one of the sections of lesser circumferential extent and an adjacent section of greater circumferential extent and a plurality of openings along the length of the body on the short radius side, the openings being in fluid communication with the channel; and,an inlet portion configured to be disposed in an anterior chamber of the eye when the body is in Schlemm's canal, the inlet portion disposed on a proximal end of the body in fluid communication with the channel, the inlet portion defining an open channel along at least a portion of its length in fluid communication with the anterior chamber of the eye. 22. The ocular implant of claim 21 wherein each section of greater circumferential extent comprises a pair of struts, the sections of greater circumferential extent being separated by the sections of lesser circumferential extent comprising spine sections, the struts and spine sections defining the channel. 23. The ocular implant of claim 22 wherein each of the plurality of openings is disposed between a pair of the struts. 24. The ocular implant of claim 21 wherein the plurality of openings are disposed generally opposite the open side of the channel. 25. The ocular implant of claim 21 wherein the plurality of openings are disposed 140°-150° from the open side of the open channel. 26. The ocular implant of claim 21 wherein the body of the implant is adapted to extend at least about 60° around a circle formed by Schlemm's canal. 27. The ocular implant of claim 21 wherein the plurality of openings and the open side of the channel extend over more than 50% of a hypothetical surface covering the body portion of the implant adapted to lie within Schlemm's canal. 28. The ocular implant of claim 21 wherein the ocular implant provides a material coverage of Schlemm's canal of less than 50% over 90% of the ocular implant's length. 29. The ocular implant of claim 21 wherein the ocular implant has a generally curved resting shape. 30. The ocular implant of claim 29 wherein the resting shape forms an arc of a circle, the inlet portion lying along the arc.
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