초록

Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.

대표청구항 ▼

1. An isolated peptide having the amino acid sequence of Y-C-F-P-D-E-E-G-A-C-Y (SEQ ID NO:3), G-G-S-Y-C-F-P-D-E-E-G-A-C-Y (SEQ ID NO:6), Y-C-F-Y-P-D-E-E-G-A-C-Y (SEQ ID NO:12), Y-C-F-P-D-E-E-G-A-C-Y-K (SEQ ID NO: 25), or Y-C-F-P-D-E-E-G-A-C-Y-G-G-S (SEQ ID NO: 26). 2. The isolated peptide of claim 1

1. An isolated peptide having the amino acid sequence of Y-C-F-P-D-E-E-G-A-C-Y (SEQ ID NO:3), G-G-S-Y-C-F-P-D-E-E-G-A-C-Y (SEQ ID NO:6), Y-C-F-Y-P-D-E-E-G-A-C-Y (SEQ ID NO:12), Y-C-F-P-D-E-E-G-A-C-Y-K (SEQ ID NO: 25), or Y-C-F-P-D-E-E-G-A-C-Y-G-G-S (SEQ ID NO: 26). 2. The isolated peptide of claim 1, said peptide having the amino acid sequence of Y-C-F-P-D-E-E-G-A-C-Y (SEQ ID NO:3). 3. The isolated peptide of claim 2, further comprising a carboxy-terminal hydroxyl group. 4. The isolated peptide of claim 1, said peptide having the amino acid sequence of G-G-S-Y-C-F-P-D-E-E-G-A-C-Y (SEQ ID NO:6). 5. The isolated peptide of claim 4, further comprising a carboxy-terminal NH2 group. 6. The isolated peptide of claim 1, said peptide having the amino acid sequence of Y-C-F-Y-P-D-E-E-G-A-C-Y (SEQ ID NO:12). 7. The isolated peptide of claim 6, further comprising a carboxy-terminal NH2 group. 8. The isolated peptide of claim 1, said peptide having the amino acid sequence of Y-C-F-P-D-E-E-G-A-C-Y-K (SEQ ID NO: 25). 9. The isolated peptide of claim 1, said peptide having the amino acid sequence of Y-C-F-P-D-E-E-G-A-C-Y-G-G-S (SEQ ID NO: 26). 10. The isolated peptide of claim 9, further comprising a carboxy-terminal NH2 group.