A method and device is provided for collecting filterable material to perform assays on a filtration apparatus by applying negative-pressure to the inlet chamber of the filtration apparatus which is independent of negative or positive pressure applied to its fluid path. The negative-pressure applied
A method and device is provided for collecting filterable material to perform assays on a filtration apparatus by applying negative-pressure to the inlet chamber of the filtration apparatus which is independent of negative or positive pressure applied to its fluid path. The negative-pressure applied to the inlet chamber serves to actively aspirate fluid and promote flow into the inlet chamber via the fluid pathway. The negative-pressure applied to the inlet chamber facilitates the use of either negative or positive-pressure based fluid-filtration approaches. Use of the invention improves the functionality and scope of applications that can be performed with enclosed filtration apparatuses.
대표청구항▼
1. A filter apparatus for separating and collecting filterable material from a fluid, the apparatus comprising: (i) an enclosed housing capable of holding and passing fluid;(ii) a vent through which negative pressure is applied, the vent located in the wall of said enclosed housing;(iii) a fluid inl
1. A filter apparatus for separating and collecting filterable material from a fluid, the apparatus comprising: (i) an enclosed housing capable of holding and passing fluid;(ii) a vent through which negative pressure is applied, the vent located in the wall of said enclosed housing;(iii) a fluid inlet capable of allowing introduction of fluid into said filter apparatus;(iv) a hydrophilic filter confined within said housing capable of allowing filterable material to be separated from said fluid, concentrated and retained within said housing;(v) a fluid outlet capable of allowing discharge of fluid out of the filter apparatus; and(vi) a hydrophobic filter positioned inside the vent, wherein the vent is located on the fluid inlet side of the housing and is capable of actively and continuously delivering negative pressure to the fluid inlet side of the hydrophilic filter;wherein the hydrophilic filter separates the fluid inlet from the fluid outlet; andwherein the filter apparatus separates and collects filterable material from a fluid. 2. The filter apparatus according to claim 1, wherein said hydrophilic filter includes physical, chemical, biological, charge and/or magnetic based means to separate filterable material from the fluid. 3. The filter apparatus according to claim 1, wherein said hydrophilic filter is a porous filter element capable of removing filterable material from the fluid that is passed through it. 4. The filter apparatus according to claim 3, wherein said porous element is a filter membrane made from materials selected from the group consisting of nitrocellulose, mixed cellulose esters, polyether sulfone, nylon, polycarbonate, polyvinyl, cellulose, glass, ceramics, and alumina. 5. The filter apparatus according to claim 1, wherein said hydrophobic vent may also include a ball-valve, flexible seal or moveable cover. 6. The filter apparatus according to claim 1 having at least one portion thereof made of transmissive material capable of allowing the contents of said filter apparatus to be viewed or measured by optical means. 7. The filter apparatus according to claim 1, wherein said filter apparatus can be opened thereby allowing extraction of separated and retained said filterable material from said filter apparatus. 8. The filter apparatus according to claim 1, wherein said filter apparatus can be opened thereby allowing extraction of said hydrophilic filter from the filter apparatus. 9. The filter apparatus according to claim 1, wherein said filter apparatus is capable of retaining fluid. 10. The filter apparatus according to claim 1, wherein said filter apparatus is capable of being incubated at temperatures up to 70 degrees centigrade. 11. The filter apparatus according to claim 1, wherein said filter apparatus is made of polymeric material selected from the group consisting of polystyrene, polycarbonate, polypropylene, nylon acrylics, silicone and flexible elastomer. 12. The filter apparatus according to claim 1, wherein said negative pressure is applied externally to said vent through a separate suction apparatus comprising: (i) means for attaching said suction apparatus to said filtration apparatus;(ii) a fluid path capable of delivering continuous and/or intermittent suction to said aspiration means; and(iii) a controller for regulating the timing and amount of suction applied to said aspiration means of said filtration apparatus. 13. The filter apparatus according to claim 12, wherein said fluid path prevents liquid flow from said vent getting into said suction apparatus. 14. The filter apparatus according to claim 12, wherein said suction apparatus further includes: a fluid path capable of delivering continuous and/or intermittent suction to said fluid outlet of said filtration apparatus thereby permitting fluid flow through and/or out of said filter apparatus; anda controller for regulating the timing, and amount of suction applied to said fluid outlet of said filtration apparatus. 15. The filter apparatus according to claim 14, wherein said aspiration of said fluid into said filter apparatus and the said passage of fluid through said filter apparatus are independently controllable. 16. The filter apparatus according to claim 14, wherein a volume of said fluid exposed to the hydrophilic filter is limited and/or regulated. 17. The filter apparatus according to claim 16, wherein said volume of said fluid is limited and/or regulated using an electronic volumetric meter, mechanical volumetric meter, fixed volume suction apparatus, and/or controlled vacuum pump. 18. The filter apparatus according to claim 14, wherein said volume of said fluid exposed to the hydrophilic filter is limited and/or regulated by a controlled volume collection apparatus utilizing a ball valve, movable flap, and/or hydrophobic vent. 19. The filter apparatus according to claim 1 wherein said filtration apparatus is partitioned to provide a plurality of filters, each separated to function independently.
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이 특허에 인용된 특허 (12)
Dickens Duane D. (Irvine CA) Servas Francis M. (San Juan Capistrano CA), Arterial blood filter with improved gas venting.
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