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Compounds and methods for modulating expression of DGAT2

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C07H-021/02
  • C07H-021/04
  • A61K-031/70
  • C12N-015/113
  • C12Q-001/68
출원번호 US-0662263 (2012-10-26)
등록번호 US-8969316 (2015-03-03)
발명자 / 주소
  • Bhanot, Sanjay
  • Geary, Richard S.
  • McKay, Robert
  • Monia, Brett P.
  • Seth, Punit P.
  • Siwkowski, Andrew M.
  • Swayze, Eric E.
  • Wancewicz, Edward
출원인 / 주소
  • Isis Pharmaceuticals, Inc.
대리인 / 주소
    Isis Pharmaceutical, Inc.
인용정보 피인용 횟수 : 0  인용 특허 : 152

초록

The present disclosure describes short antisense compounds, including such compounds comprising chemically-modified high-affinity monomers 8-16 monomers in length. Certain such short antisense compound are useful for the reduction of target nucleic acids and/or proteins in cells, tissues, and animal

대표청구항

1. A short antisense compound 8 to 14 monomers in length, comprising a 2′-deoxyribonucleotide gap region flanked on each side by a wing, wherein each wing independently comprises 1 to 3 high-affinity modified monomers, wherein the short antisense compound has a motif selected from the group consisti

이 특허에 인용된 특허 (152)

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