초록

The present disclosure relates to compounds and medical devices activated with a solvophobic material functionalized with a first reactive member and methods of making such compounds and devices.

대표청구항 ▼

1. A method of forming an activated medical device comprising: preparing a composition by combining a solvent matrix including at least one polymer with a compound which includes a solvophilic material and a solvophobic material, the solvophobic material functionalized with a first click reactive me

1. A method of forming an activated medical device comprising: preparing a composition by combining a solvent matrix including at least one polymer with a compound which includes a solvophilic material and a solvophobic material, the solvophobic material functionalized with a first click reactive member to form a blend, andforming at least a portion of a medical device from the composition, wherein the blend of the solvent matrix and the compound forms a polymeric substrate and the solvophobic material and the first reactive member are positioned at or near a surface of the medical device to activate the surface of the medical device. 2. The method of claim 1, wherein the first click reactive member is an alkyne group. 3. The method of claim 1, wherein the first click reactive member is an azide group. 4. The method of claim 1, wherein the solvent matrix is selected from the group consisting of a solid, a gel and a liquid. 5. The method of claim 1, wherein the solvent matrix is hydrophilic. 6. The method of claim 5, wherein the solvophilic material includes polyamides, hydrophilic polyurethanes, polylactones, polyimides, polylactams, poly-vinyl-pyrrolidone, polyvinyl alcohols, polyacrylic acid, polymethacrylic acid, poly(hydroxyethyl methacrylate), gelatin, dextran, oligosaccharides, chitosan, hyaluronic acid, alginate, chondroitin, mixtures and combinations thereof. 7. The method of claim 5, wherein the solvophobic material includes polyethylene, polypropylene, hydrophobic polyurethanes, polyacrylates, polymethacrylates, fluoropolymers, polycaprolactone, polylactide, polyglycolide, phospholipids, and polyureas, poly(ethylene-vinyl acetate), polyvinylchloride, polyesters, polyamides, polycarbonate, polystyrenes, polytetrafluoroethylene, silicones, siloxanes, fatty acids, and chitosan having high degrees of acetylation and mixtures and combinations thereof. 8. The method of claim 5, wherein the solvophilic material is chitosan having a degree of acetylation from 0 to about 30% and the solvophobic material is chitosan having a degree of acetylation greater than about 50%. 9. The method of claim 1, wherein the polymer of the solvent matrix is a naturally biodegradable polymer. 10. The method of claim 9, wherein the naturally biodegradable polymer is collagen. 11. The method of claim 1 wherein the solvophilic material is covalently bonded to the solvophobic material. 12. The method of claim 1, wherein the medical device is a fiber. 13. The method of claim 12, wherein the fiber is used to form a textile. 14. The method of claim 1, further comprising adding a bioactive agent functionalized with a second click reactive member to covalently bond the bioactive agent to the solvophobic material via the first and second reactive members. 15. The method of claim 14, wherein the first click reactive member is an azide and the second click reactive member is an alkyne. 16. The method of claim 14, wherein the first click reactive member is an alkyne and the second click reactive member is an azide. 17. The method of claim 1, wherein the solvent matrix further includes at least one solvent.