초록 ▼

A device to treat an aneurysm can include a plurality of soft and compressible fill members. A flow conduit can carry the fill members in a liquid flow. A flexible, expandable, and liquid-permeable net or mesh enclosure can be inserted into and to fit within the aneurysm. The net or mesh enclosure c

A device to treat an aneurysm can include a plurality of soft and compressible fill members. A flow conduit can carry the fill members in a liquid flow. A flexible, expandable, and liquid-permeable net or mesh enclosure can be inserted into and to fit within the aneurysm. The net or mesh enclosure can receive and retain the plurality of fill members while openings in the net or mesh enclosure allow enough liquid flow through the net or mesh enclosure to transport the fill members into the net or mesh enclosure. A resulting accumulation of the plurality of fill members within the net or mesh enclosure causes the net or mesh enclosure to expand and to come into contact with and generally conform with an interior wall of the aneurysm. This can substantially occlude the aneurysm and retain the net or mesh enclosure within the aneurysm.

대표청구항 ▼

1. A device to treat an aneurysm comprising: a plurality of individual soft and compressible non-liquid fill members;a flow conduit, providing a liquid flow that carries the individual, non-liquid fill members using the liquid flow;a flexible, expandable, and liquid-permeable net or mesh enclosure,

1. A device to treat an aneurysm comprising: a plurality of individual soft and compressible non-liquid fill members;a flow conduit, providing a liquid flow that carries the individual, non-liquid fill members using the liquid flow;a flexible, expandable, and liquid-permeable net or mesh enclosure, configured to be inserted into and to fit within the aneurysm, wherein the net or mesh enclosure comprises a primary opening that is configured to receive the plurality of individual, non-liquid fill members into the net or mesh enclosure and wherein the primary opening is closable after the plurality of individual, non-liquid fill members have been received into the net or mesh enclosure; and wherein the net or mesh enclosure further comprises a plurality of secondary openings that allow the liquid flow that carried the individual, non-liquid fill members into the net or mesh enclosure to pass through the net or mesh enclosure but retain the plurality of individual, non-liquid fill members within the net or mesh enclosure, wherein a resulting accumulation of the plurality of individual, non-liquid fill members within the net or mesh enclosure causes the net or mesh enclosure to expand and to come into contact with the aneurysm walls to thereby substantially occlude the aneurysm and retain the net or mesh enclosure within the aneurysm, wherein at least some of the non-liquid fill members retained by the net or mesh enclosure partially protrude out from the net or mesh enclosure to assist in conformal gripping of the interior aneurysm wall; wherein a proximal region of the net or mesh enclosure has a first strength, flexibility, plasticity, or elasticity; wherein a distal region of the net or mesh enclosure has a second strength, flexibility, plasticity, or elasticity; wherein there is a difference between the first strength, flexibility, plasticity, or elasticity and the second strength, flexibility, plasticity, or elasticity; anda user-actuatable closure, associated with the primary opening in the net or mesh enclosure through which the individual non-liquid fill members are introduced into the enclosure, wherein the closure is configured to be user-actuated to reduce a size of the primary opening after the net or mesh enclosure has been expanded by filling it with the fill members. 2. The device of claim 1, wherein the plurality of individual, non-liquid fill members are non-inflammatory, implantably non-biodegradable, and anti-bacterial or anti-microbial, and at least one of the individual, non-liquid fill members comprises at least one of a sponge material, a foam material, or a gel material. 3. The device of claim 1, wherein at least one of the individual, non-liquid fill members is configured to be shaped as at least one of a sphere, an ovoid, an ellipsoid, or a polyhedron. 4. The device of claim 1, wherein the individual, non-liquid fill members include a Shore OO value within a range of about 5 to about 50. 5. The device of claim 1, wherein the individual, non-liquid fill members include a size within a range of about 50 micrometers to about 2000 micrometers. 6. The device of claim 1, wherein the plurality of individual, non-liquid fill members includes fill members of different sizes. 7. The device of claim 1, wherein the individual, non-liquid fill members include a material causing more adhesion of the individual, non-liquid fill members to each other in the presence of cerebrospinal fluid (CSF) than in the presence of blood. 8. The device of claim 1, wherein the individual, non-liquid fill members are radio-opaque. 9. The device of claim 1, wherein the net or mesh enclosure comprises at least one of a nylon material, a polypropylene material, a polyester material, or a polytetrafluorethylene material, or a polytetrafluoroethene material. 10. The device of claim 1, wherein the net or mesh enclosure is initially folded or compressed for insertion into the aneurysm. 11. The device of claim 1, wherein the net or mesh enclosure is radiolucent. 12. The device of claim 1, wherein the net or mesh enclosure is echogenic. 13. The device of claim 1, wherein the net or mesh enclosure is MR-visible. 14. The device of claim 1, wherein the net or mesh enclosure is configured with at least one of a differential strength, differential flexibility, differential plasticity, or differential elasticity between different regions of the net or mesh enclosure. 15. The device of claim 1, further comprising an elongated flexible intravascular member sized and shaped for intravascularly transporting the individual, non-liquid fill members and the net or mesh enclosure into the aneurysm. 16. The device of claim 15, wherein the elongated flexible intravascular member comprises a catheter comprising the conduit. 17. The device of claim 16, wherein the net or mesh enclosure comprises the primary opening configured to be drawn shut using a closure that is detachable from the elongated flexible intravascular member or detachable from an instrument or mechanism associated with the elongated flexible intravascular member. 18. The device of claim 16, wherein the closure comprises at least one of a cord, a wire, a tie-off, a threaded member, a shape-memory material, a clasp, an adhesive, or a fusion. 19. The device of claim 15, comprising an elongated member configured to extend outward from the elongated flexible intravascular member into the aneurysm within the net or mesh enclosure to push the net or mesh enclosure into the aneurysm. 20. A device to treat an aneurysm comprising: a plurality of individual non-liquid fill members;a liquid flow which transports the plurality of individual non-liquid fill members;a flow conduit through which the liquid flow moves and through which the individual non-liquid fill members move, wherein this flow conduit is configured to transport the plurality of non-liquid fill members into an aneurysm;a pump mechanism that is configured to cause the liquid flow and the plurality of individual non-liquid fill members to move through the flow conduit into the aneurysm;a flexible and liquid-permeable net or mesh enclosure that is configured to be inserted into the aneurysm; wherein the net or mesh enclosure comprises a primary opening that is configured to receive the plurality of individual non-liquid fill members into the net or mesh enclosure and wherein the primary opening is closable after a plurality of non-liquid fill members have been received into the net or mesh enclosure; wherein the net or mesh enclosure further comprises a plurality of secondary openings that allow the liquid flow to pass outwards through the net or mesh enclosure but to retain the plurality of individual non-liquid fill members within the net or mesh enclosure; wherein a resulting accumulation of the plurality of individual non-liquid fill members within the net or mesh enclosure causes the net or mesh enclosure to expand and to come into contact with the aneurysm walls to thereby substantially occlude the aneurysm; and wherein at least some of the non-liquid fill members retained by the net or mesh enclosure partially protrude out from the net or mesh enclosure to assist in conformal gripping of the interior aneurysm wall; anda closure associated with the primary opening in the net or mesh enclosure through which the individual non-liquid fill members enter the enclosure, wherein user actuated closing of this closure prevents the individual non-liquid fill members from escaping outwards from the net or mesh enclosure through this primary opening. 21. A method comprising: creating a flexible, expandable, and liquid-permeable net or mesh enclosure to occlude an aneurysm wherein a proximal region of the net or mesh enclosure has a first flexibility or elasticity; a distal region of the net or mesh enclosure has a second flexibility or elasticity; and the first flexibility or elasticity is different than the second flexibility or elasticity;inserting the flexible, expandable, and liquid-permeable net or mesh enclosure into an aneurysm;providing a liquid flow that introduces a plurality of soft and compressible individual, non-liquid fill members, using a flow conduit, into the net or mesh enclosure;receiving the individual, non-liquid fill members into the net or mesh enclosure through a primary opening in the net or mesh enclosure;retaining the individual, non-liquid fill members within the net or mesh enclosure while allowing liquid flow that carried the individual, non-liquid fill members into the net or mesh enclosure to pass through a plurality of secondary openings in the net or mesh enclosure such that a resulting accumulation of the plurality of individual, non-liquid fill members within the net or mesh enclosure causes the net or mesh enclosure to expand and to come into contact with and generally conform with an interior wall of the aneurysm to thereby substantially occlude the aneurysm and retain the net or mesh enclosure within the aneurysm;allowing at least some of the retained non-liquid fill members to partially protrude out from the net or mesh enclosure to assist in conformal gripping of an interior wall of the aneurysm; andactuating a closure to reduce the size of the primary opening, though which individual, non-liquid fill members were introduced into the net or mesh enclosure, after the net or mesh enclosure has been expanded. 22. The method of claim 21, wherein inserting the net or mesh enclosure into the aneurysm comprises inserting an initially folded or compressed net or mesh enclosure into the aneurysm. 23. The method of claim 21, comprising intravascularly guiding a distal portion of an elongated flexible member to an aneurysm for inserting the net or mesh enclosure into the aneurysm, for introducing the individual, non-liquid fill members into the net or mesh enclosure, and for accumulating enough of the individual, non-liquid fill members within the net or mesh enclosure to expand the net or mesh enclosure. 24. The method of claim 23, comprising detaching the net or mesh enclosure from the elongated flexible member after expanding the net or mesh enclosure to substantially fill the aneurysm. 25. The method of claim 24, comprising drawing shut the primary opening of the net or mesh enclosure before detaching the net or mesh enclosure from the elongated flexible member. 26. The method of claim 21, wherein introducing a plurality of soft and compressible fill members, using a liquid flow, into the net or mesh enclosure comprises introducing at least two different sizes of individual, non-liquid fill members. 27. The method of claim 26, wherein the introducing at least two different sizes of individual, non-liquid fill members is carried out in response to user-actuation controlling which size of individual, non-liquid fill member is to be introduced. 28. The method of claim 21, comprising self-adhering the individual, non-liquid fill members to each other upon exposure to cerebrospinal fluid. 29. The method of claim 21, comprising using a net or mesh enclosure 26 having at least one of a differential strength, differential flexibility, differential plasticity, or differential elasticity between different regions of the net or mesh enclosure. 30. The method of claim 21, comprising viewing the individual, non-liquid fill members using a first imaging modality and viewing the net or mesh enclosure using a different second imaging modality.