IPC분류정보
국가/구분 |
United States(US) Patent
등록
|
국제특허분류(IPC7판) |
|
출원번호 |
US-0591377
(2005-03-04)
|
등록번호 |
US-8999156
(2015-04-07)
|
국제출원번호 |
PCT/US2005/007152
(2005-03-04)
|
§371/§102 date |
20070524
(20070524)
|
국제공개번호 |
WO2005/087340
(2005-09-22)
|
발명자
/ 주소 |
- Iraneta, Pamela C.
- Belanger, Jon
- Fisk, Raymond P.
|
출원인 / 주소 |
- Waters Technologies Corporation
|
대리인 / 주소 |
|
인용정보 |
피인용 횟수 :
0 인용 특허 :
16 |
초록
▼
A frit (44) includes a porous support structure having a plurality of void spaces, where a plurality of secondary particles (46) are filled in the void spaces, the secondary particles (46) being dimensioned with respect to the void spaces such that the frit (44) retains packing materials with diamet
A frit (44) includes a porous support structure having a plurality of void spaces, where a plurality of secondary particles (46) are filled in the void spaces, the secondary particles (46) being dimensioned with respect to the void spaces such that the frit (44) retains packing materials with diameters of less than about 2.5 microns. Preferably one or more frits (44) are received in a high pressure liquid chromatography (HPLC) chromatographic column, where the column includes fittings and filter assemblies for receiving frits (44) at its inlet and outlet. The frit (44) can be constructed from a porous support structure with void spaces or pores that are filled with secondary particles (46) smaller those used to manufacture the support. The particles (46) contained in the void spaces are large enough to be retained by the support, but small enough to create a finer network of interconnected channels within the support's void spaces that are capable of retaining sub-2.5 micrometer particles.
대표청구항
▼
1. A frit comprising: a porous support structure produced from sintered irregularly shaped powder particles about 45 to 100 micrometers in size, the porous support structure having a media grade between about 0.5 and about 10, and defining a plurality of void spaces; anda plurality of spherical part
1. A frit comprising: a porous support structure produced from sintered irregularly shaped powder particles about 45 to 100 micrometers in size, the porous support structure having a media grade between about 0.5 and about 10, and defining a plurality of void spaces; anda plurality of spherical particles no more than about 5 micrometers in size sintered within the porous support structure to each other, to the porous support structure surrounding the void spaces, or both, the spherical particles defining a secondary pore network within the void spaces sufficient to retain packing materials with diameters of less than about 2.5 microns within the frit,wherein the void spaces are filled with the plurality of spherical particles such that the frit has a density of at least 50% by volume. 2. The frit of claim 1, wherein the void spaces are partially filled with the particles. 3. The frit of claim 1, wherein the packing materials are chromatographic packing materials. 4. The frit of claim 1, wherein the porous support structure comprises a material selected from the group consisting of metals, metal alloys, metal oxides, ceramics, and polymers. 5. The frit of claim 1, wherein the porous support structure comprises a material selected from the group consisting of sinterable metals, sinterable metal alloys, sinterable metal oxides, sinterable ceramics, and sinterable polymers. 6. The frit of claim 1, wherein the porous support structure comprises a material selected from the group consisting of stainless steel, titanium, PEEK, polyethylene, polypropylene, synthetic resinous fluorine-containing polymers glass, silica, titania, and zirconia. 7. The frit of claim 1, wherein the porous support structure comprises stainless steel. 8. The frit of claim 1, wherein the porous support structure comprises 316 stainless steel. 9. The frit of claim 1, wherein the spherical particles range from about 3 microns to about 5 microns in diameter. 10. The frit of claim 1, wherein the spherical particles are about 3.5 microns in diameter. 11. The frit of claim 10, wherein the spherical particles are about 4 microns in diameter. 12. The frit of claim 1, wherein the spherical particles have the same composition as the porous support structure. 13. The frit of claim 1, wherein the spherical particles have a different composition than the porous support structure. 14. The frit of claim 1, wherein the spherical particles are spherical stainless steel particles. 15. The frit of claim 1 for use in a chromatography column. 16. The frit of claim 15, wherein the chromatography column is a high pressure liquid chromatography (HPLC) column. 17. The frit of claim 16, wherein the chromatography column is a high pressure liquid chromatography column packed with chromatographic packing materials with particle diameters of less than about 2.5 microns. 18. The frit of claim 1, wherein the particles fill the void spaces of the porous support structure to a depth of greater than about 10 microns. 19. The frit of claim 15, wherein the chromatography column is packed with chromatographic packing materials. 20. The frit of claim 19, wherein the chromatographic packing materials are selected from the group consisting of silica gel, derivatized silica gel, zirconia, derivatized zirconia, titanium oxide, derivatized titanium oxide, organo-silica hybrids, derivatized organo-silica hybrids, hybrids of metal oxides, and derivatized hybrids of metal oxides. 21. A frit configured to be received in a tubular chamber, the frit comprising: a porous support structure produced from sintered irregularly shaped powder particles about 45 to 100 micrometers in size, the porous support structure having a media grade between about 0.5 and about 10, and defining a plurality of void spaces; anda plurality of spherical particles sintered within the porous support structure to each other, to the porous support structure surrounding the void spaces, or both,wherein the void spaces are partially filled with the plurality of spherical particles, and the spherical particles are dimensioned with respect to the void spaces to retain chromatographic packing materials with diameters of less than about 2.5 microns.
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