초록

In order to prevent impairment of the pharmacological effect of pancreatine through added auxiliary substances or binding agents a pancreatine pellet consists exclusively of pancreatine.

대표청구항 ▼

1. A pancreatine pellet comprising a core consisting of pancreatine, and a coating comprising pancreatine, which coating has a first inner layer and a second outer layer,wherein the first inner layer surrounds the core and comprises auxiliary substances and binding agents, in an amount between 5-30%

1. A pancreatine pellet comprising a core consisting of pancreatine, and a coating comprising pancreatine, which coating has a first inner layer and a second outer layer,wherein the first inner layer surrounds the core and comprises auxiliary substances and binding agents, in an amount between 5-30% by weight of the pancreatine pellet,wherein the auxiliary substances, binding agents and pancreatine of the coating are homogeneously dispersed in the first inner layer,and wherein the second outer layer comprises a material that is resistant to gastric juices, in an amount between 10-30% by weight of the pancreatine pellet,and wherein the pancreatine pellet has a drop-like or spherical shape. 2. The pancreatine pellet according to claim 1, wherein the pellet is a micropellet. 3. The pancreatine pellet according to claim 1, wherein the pancreatine is obtained from the pancreas of a mammal. 4. The pancreatine pellet according to claim 1, wherein the diameter of the sphere or the shorter axis lies in the range of 0.4 to 0.8 mm. 5. A pharmaceutical composition, comprising a pharmacologically active quantity of pancreatine pellets which comprise a core consisting of pancreatine, which core contains no auxiliary substances and binding agents, and a coating comprising pancreatine, which coating has a first inner layer and a second outer layer,wherein the first inner layer surrounds the core and comprises auxiliary substances and binding agents, in an amount between 5-30% by weight of the pancreatine pellet,wherein the auxiliary substances, binding agents and pancreatine of the coating are homogeneously dispersed in the first inner layer,and wherein the second outer layer comprises a material that is resistant to gastric juices, in an amount between 10-30% by weight of the pancreatine pellet,and wherein the pancreatine pellet has a drop-like or spherical shape. 6. The pharmaceutical composition according to claim 5, in a dosage form that is suitable for oral administration.