Nutritional supplements and methods for maintaining and/or improving the condition of bones or cartilage in a mammal, particularly a human. One such supplement comprises demineralized bone matrix (DBM) wherein the DBM comprises a bone growth improving amount of at least one osteoinductive growth fac
Nutritional supplements and methods for maintaining and/or improving the condition of bones or cartilage in a mammal, particularly a human. One such supplement comprises demineralized bone matrix (DBM) wherein the DBM comprises a bone growth improving amount of at least one osteoinductive growth factor. A preferred supplement composition further comprises at least one vitamin, such as vitamin E. One method comprises orally administering to the mammal on a periodic basis a supplement comprising DBM. In a preferred method the DBM composition is periodically administered and there is a further periodic administration of a therapeutically effective amount of a calcium-containing composition; the calcium-containing composition is administered temporally spaced apart from said DBM composition for maximum effectiveness.
대표청구항▼
1. A nutritional supplement, comprising demineralized bone matrix (DBM) derived from a source of bone comprising native bone-active substances wherein said native bone-active substances in said source of bone comprise native Bone Morphogenic Proteins, (BMPs) and native Transforming Growth Factors-be
1. A nutritional supplement, comprising demineralized bone matrix (DBM) derived from a source of bone comprising native bone-active substances wherein said native bone-active substances in said source of bone comprise native Bone Morphogenic Proteins, (BMPs) and native Transforming Growth Factors-beta, (TGF-beta),said DBM comprising at least one native bone active substance selected from the group consisting of native Bone Morphogenic Proteins, (BMPs) and native Transforming Growth Factors, (TGF-beta),wherein said DBM, BMPs and TGF-beta are in therapeutically effective amounts to manage a bone or joint condition or bone or joint health in a subject, and wherein, said supplement being orally administrable to a subject. 2. The supplement of claim 1 comprising at least one BMP wherein said DBM comprises between about 0 to about 6 wt % native calcium. 3. The supplement of claim 2 comprising at least one of an orally ingestible pharmaceutically acceptable carrier, filler or excipient. 4. The supplement of claim 3 comprising about 50 mg to about 800 mg of DBM. 5. The supplement of claim 3 wherein said bone active substance is native BMP. 6. The supplement of claim 3 further comprising at least one vitamin, including salts, isomeric forms and derivatives of said vitamin. 7. The supplement of claim 6 wherein said at least one vitamin is selected from the group consisting of vitamin D, vitamin E, B vitamins; vitamin K; carotene-containing compounds; and combinations thereof. 8. The supplement of claim 2 wherein said DBM comprises collagen type I and collagen type II and at least one member selected from the group consisting of TGF-β2, TGF-β1, BMP-2, BMP-3, BMP-4, BMP-5, BMP-6, BMP-7, BMP-8, BMP-9, BMP-10, IGF-I, IGF-II, PDGF-AA, PDGF-BB, PDGF-AB, β-FGF and VEGF. 9. The supplement of claim 7 wherein said at least one vitamin is vitamin E. 10. The supplement of claim 9 wherein said vitamin E is present at about 5 IU to about 500 IU. 11. The supplement of claim 3 in an orally administrable unit dosage form wherein said supplement is for oral administration to a mammal. 12. The supplement of claim 11 wherein said mammal is a human. 13. The supplement of claim 12 wherein the source of bone from which the DBM is derived is bovine, porcine or other farm animal. 14. The supplement of claim 13 wherein said source bone is bovine.
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