$\require{mediawiki-texvc}$

연합인증

연합인증 가입 기관의 연구자들은 소속기관의 인증정보(ID와 암호)를 이용해 다른 대학, 연구기관, 서비스 공급자의 다양한 온라인 자원과 연구 데이터를 이용할 수 있습니다.

이는 여행자가 자국에서 발행 받은 여권으로 세계 각국을 자유롭게 여행할 수 있는 것과 같습니다.

연합인증으로 이용이 가능한 서비스는 NTIS, DataON, Edison, Kafe, Webinar 등이 있습니다.

한번의 인증절차만으로 연합인증 가입 서비스에 추가 로그인 없이 이용이 가능합니다.

다만, 연합인증을 위해서는 최초 1회만 인증 절차가 필요합니다. (회원이 아닐 경우 회원 가입이 필요합니다.)

연합인증 절차는 다음과 같습니다.

최초이용시에는
ScienceON에 로그인 → 연합인증 서비스 접속 → 로그인 (본인 확인 또는 회원가입) → 서비스 이용

그 이후에는
ScienceON 로그인 → 연합인증 서비스 접속 → 서비스 이용

연합인증을 활용하시면 KISTI가 제공하는 다양한 서비스를 편리하게 이용하실 수 있습니다.

Modular DNA-binding domains and methods of use 원문보기

IPC분류정보
국가/구분 United States(US) Patent 등록
국제특허분류(IPC7판)
  • C12N-005/071
  • C12N-001/20
  • C12N-005/04
  • C07K-014/195
출원번호 US-0153241 (2014-01-13)
등록번호 US-9017967 (2015-04-28)
우선권정보 DE-10 2009 004 659 (2009-01-12); EP-09165328 (2009-07-13)
발명자 / 주소
  • Bonas, Ulla
  • Boch, Jens
  • Schornack, Sebastian
  • Lahaye, Thomas
출원인 / 주소
  • Bonas, Ulla
대리인 / 주소
    Williams Mullen PC
인용정보 피인용 횟수 : 0  인용 특허 : 45

초록

The present invention refers to methods for selectively recognizing a base pair in a DNA sequence by a polypeptide, to modified polypeptides which specifically recognize one or more base pairs in a DNA sequence and, to DNA which is modified so that it can be specifically recognized by a polypeptide

대표청구항

1. A non-human animal cell or in vitro human cell comprising a fusion protein, the fusion protein comprising an artificial transcription activator-like (TAL) effector repeat domain of contiguous repeat units 33 to 35 amino acids in length and an endonuclease domain, wherein the repeat domain is engi

이 특허에 인용된 특허 (45)

  1. Pomerantz Joel L. ; Sharp Phillip A. ; Pabo Carl O., Chimeric DNA-binding proteins.
  2. Saifer Mark (Berkeley CA) Somack Ralph (Oakland CA) Williams L. David (Fremont CA), Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols.
  3. Somers David A. (Roseville MN) Parker William B. (Roseville MN) Wyse Donald L. (Wyoming MN) Gronwald John W. (Shoreview MN) Gengenbach Burle G. (St. Paul MN), Corn plants tolerant to sethoxydim and haloxyfop herbicides.
  4. Goodman Howard (Newton MA) DasSarma Shiladitya (Amherst MA) Tischer Edmund (Palo Alto CA) Peterman Theresa K. (Cambridge MA), Expression of wild type and mutant glutamine synthetase in foreign hosts.
  5. Lundquist Ronald C. (Minnetonka MN) Walters David A. (Bloomington MN), Fertile glyphosate-resistant transgenic corn plants.
  6. Chandrasegaran Srinivasan (Baltimore MD), Functional domains in flavobacterium okeanokoites (FokI) restriction endonuclease.
  7. Chandrasegaran Srinivasan (Baltimore MD), Functional domains in flavobacterium okeanokoities (foki) restriction endonuclease.
  8. Chandrasegaran Srinivasan, General method to clone hybrid restriction endonucleases using lig gene.
  9. Leemans Jan (Heusden BEX) Botterman Johan (Zwijnaarde BEX) De Block Marc (Gentbrugge BEX) Thompson Charles (Grand Lancy/Genege CHX) Mouva Rao (Genev CHX), Genetically engineered plant cells and plants exhibiting resistance to glutamine synthetase inhibitors, DNA fragments an.
  10. Alan Victor Ottaway GB; Carl Andrew Formstone GB; Derek John Hopkins GB; Michael John Bean GB, Glyphosate formulation.
  11. Shah Dilip M. (Creve Coeur MO) Rogers Stephen G. (Chesterfield MO) Horsch Robert B. (both St. Louis MO) Fraley Robert T. (both St. Louis MO), Glyphosate-resistant plants.
  12. Stalker David M. (Davis CA), Haloarylnitrile degrading gene, its use, and cells containing the gene.
  13. Thomas Homer Beckett ; Stott Willie Howard, Herbicidal compositions of glyphosate trimesium.
  14. Anderson Paul C. (Minneapolis MN) Hibberd Kenneth A. (Falcon Heights MN), Herbicide resistance in plants.
  15. Volrath Sandra L. ; Johnson Marie A. ; Ward Eric R. ; Heifetz Peter B., Herbicide-tolerant protoporphyrinogen oxidase ("protox") genes.
  16. Comai Luca (Davis CA), Inhibition resistant 5-enolpyruvyl-3-phosphoshikimate synthase, production and use.
  17. Chandrasegaran Srinivasan (Baltimore MD), Insertion and deletion mutants of FokI restriction endonuclease.
  18. Cox, III,George Norbert; Case,Casey Christopher; Eisenberg,Stephen P.; Jarvis,Eric Edward; Spratt,Sharon Kaye, Ligand-controlled regulation of endogenous gene expression.
  19. Sanford John C. (Geneva) DeVit Michael J. (Geneva NY) Bruner Ronald F. (Sewell NJ) Johnston Stephen A. (Durham NC), Method and apparatus for introducing biological substances into living cells.
  20. Lundquist Ronald C. (Minnetonka MN) Walters David A. (Bloomington MN), Method for preparing fertile transgenic corn plants.
  21. Hiei Yukoh,JPX, Method for transforming indica rice.
  22. Hiei Yokoh (Iwata-gun JPX) Komari Toshihiko (Iwata-gun JPX), Method for transforming monocotyledons.
  23. Steven Olson, Method of swinging on a swing.
  24. Case, Casey C.; Elizabeth Wolffe, ; Urnov, Fyodor; Lai, Albert; Snowden, Andrew; Tan, Siyuan; Gregory, Philip, Modulation of endogenous gene expression in cells.
  25. Case,Casey C.; Wolffe, legal representative,Elizabeth; Urnov,Fyodor; Lai,Albert; Snowden,Andrew; Tan,Siyuan; Gregory,Philip; Wolffe, deceased,Alan, Modulation of endogenous gene expression in cells.
  26. Sathasivan Kanagasabapathi ; Murai Norimoto, Mutant acetolactate synthase gene from Ararbidopsis thaliana for conferring imidazolinone resistance to crop plants.
  27. Davis Frank F. (19 Farmingdale Rd. East Brunswick NJ 08816) Van Es Theodorus (313 Overbrook Rd. Piscataway NJ 08854) Palczuk Nicholas C. (45 W. Franklin St. Bound Brook NJ 08805), Non-immunogenic polypeptides.
  28. Bedbrook John R. (Piedmont CA) Chaleff Roy S. (Pennington NJ) Falco Saverio C. (Arden DE) Mazur Barbara J. (Wilmington DE) Somerville Christopher R. (Okemon MI) Yadav Narendra S. (Wilmington DE), Nucleic acid fragment encoding herbicide resistant plant acetolactate synthase.
  29. Strauch Eckhard (Bielefeld DEX) Arnold Walter (Bielefeld DEX) Alijah Renate (Bielefeld DEX) Wohlleben Wolfgang (Bielefeld DEX) Phler Alfred (Bielefeld DEX) Eckes Peter (Kelkheim/Taunus DEX) Donn Gunt, Phosphinothricin-resistance gene, and its use.
  30. Strauch Eckhard,DEX ; Wohlleben Wolfgang,DEX ; Arnold Walter,DEX ; Alijah Renate,DEX ; Puhler Alfred,DEX ; Wohner Gerhard,DEX ; Marquardt Rudiger,DEX ; Grabley Susanne,DEX ; Brauer Dieter,DEX ; Barts, Phosphinothricin-resistance gene, and its use.
  31. Mullis Kary B. (Kensington CA) Erlich Henry A. (Oakland CA) Arnheim Norman (Woodland Hills CA) Horn Glenn T. (Emeryville CA) Saiki Randall K. (Richmond CA) Scharf Stephen J. (Berkeley CA), Process for amplifying, detecting, and/or-cloning nucleic acid sequences.
  32. Offringa Remko (Leiden NLX) De Groot Marcellus J. A. (Utrecht NLX) Hooykaas Paul J. J. (Oegstgeest NLX) Van Den Elzen Petrus J. M. (Voorhout NLX), Process for the site-directed integration of DNA into the genome of plants.
  33. Choo, Yen; Ullman, Christopher Graeme; Chua, Nam Hai; Sanchez, Juan Pablo, Regulated gene expression in plants.
  34. Choo,Yen; Ullman,Christopher Graeme; Chua,Nam Hai; Sanchez,Juan Pablo, Regulated gene expression in plants.
  35. Case,Casey C.; Cox, III,George N.; Eisenberg,Stephen P.; Liu,Qiang; Rebar,Edward J., Regulation of endogenous gene expression in cells using zinc finger proteins.
  36. Cox, III, George Norbert; Case, Casey Christopher; Eisenberg, Stephen P.; Jarvis, Eric Edward; Spratt, Sharon Kaye, Regulation of endogenous gene expression in cells using zinc finger proteins.
  37. Cox, III, George Norbert; Case, Casey Christopher; Eisenberg, Stephen P.; Jarvis, Eric Edward; Spratt, Sharon Kaye, Regulation of endogenous gene expression in cells using zinc finger proteins.
  38. Cox, III,George Norbert; Case,Casey Christopher; Eisenberg,Stephen P.; Jarvis,Eric Edward; Spratt,Sharon Kaye, Regulation of endogenous gene expression in cells using zinc finger proteins.
  39. Miller,Jeffrey; Li,Guofu; Pabo,Carl; Collingwood,Trevor, Simultaneous modulation of multiple genes.
  40. Sauer Brian L. (Greenville DE), Site-specific recombination of DNA in eukaryotic cells.
  41. Kakefuda Genichi ; Ott Karl-Heinz ; Kwagh Jae-Gyu ; Stockton Gerald W., Structure-based designed herbicide resistant products.
  42. Wolffe,Alan P., Targeted modification of chromatin structure.
  43. Arnould, Sylvain; Bruneau, Sylvia; Cabaniols, Jean-Pierre; Chames, Patrick; Choulika, Andre; Duchateau, Philippe; Epinat, Jean-Charles; Gouble, Agnes; Lacroix, Emmanuel; Paques, Frederic; Perez-Michaut, Christophe; Smith, Julianne; Sourdive, David, Use of meganucleases for inducing homologous recombination ex vivo and in toto in vertebrate somatic tissues and application thereof.
  44. Jamieson,Andrew; Li,Guofu, Zinc finger proteins for DNA binding and gene regulation in plants.
  45. Jamieson,Andrew; Li,Guofu, Zinc finger proteins for DNA binding and gene regulation in plants.
섹션별 컨텐츠 바로가기

AI-Helper ※ AI-Helper는 오픈소스 모델을 사용합니다.

AI-Helper 아이콘
AI-Helper
안녕하세요, AI-Helper입니다. 좌측 "선택된 텍스트"에서 텍스트를 선택하여 요약, 번역, 용어설명을 실행하세요.
※ AI-Helper는 부적절한 답변을 할 수 있습니다.

선택된 텍스트

맨위로