초록 ▼

Methods of treating necrotic enteritis are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointes

Methods of treating necrotic enteritis are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.

대표청구항 ▼

1. A method of inhibiting the onset of, and treating, a gastrointestinal spasm associated with necrotic enteritis in a subject, the method comprising: administering an effective amount of a composition to a subject exposed to bacteria that cause necrotic enteritis with an associated gastrointestinal

1. A method of inhibiting the onset of, and treating, a gastrointestinal spasm associated with necrotic enteritis in a subject, the method comprising: administering an effective amount of a composition to a subject exposed to bacteria that cause necrotic enteritis with an associated gastrointestinal spasm, the composition having a water soluble tannin combined with hydrogen peroxide in a pharmaceutically acceptable excipient;wherein,the tannin has a molecular weight ranging from about 170 Daltons to about 4000 Daltons;the tannin:peroxide weight ratio ranges from about 1:1000 to about 10:1; and,the composition inhibits the onset of, and treats, a gastrointestinal spasm associated with necrotic enteritis in the subject when compared to a second subject in a control group also exposed to bacteria that cause necrotic enteritis in which the composition was not administered. 2. The method of claim 1, wherein the tannin is a hydrolysable tannin. 3. The method of claim 1, wherein the tannin is a water soluble condensed tannin. 4. The method of claim 1, wherein the tannin is a mixture of a hydrolysable tannin and a water soluble condensed tannin. 5. The method of claim 1, wherein the tannin is a flavanol. 6. The method of claim 1, wherein the tannin is a catechin. 7. The method of claim 1, wherein the tannin is gallic acid, epigallic acid, or a combination thereof. 8. The method of claim 1, wherein the tannin is a gallotannin. 9. The method of claim 1, wherein the tannin is an ellagitannin. 10. The method of claim 1, wherein the tannin is a punicalagin. 11. The method of claim 1, wherein the tannin is combined with the hydrogen peroxide as a component of a water extract of a plant tissue. 12. The method of claim 1, wherein the tannin is combined with the hydrogen peroxide as a component of an alcohol extract of a plant tissue. 13. The method of claim 2, wherein the hydrolysable tannin is a product of a water extraction of Chinese gall. 14. The method of claim 1, wherein the tannin is a hydrolysable tannin having from 3-12 galloyl residues. 15. A method of inhibiting the onset of, and treating, a gastrointestinal spasm associated with necrotic enteritis in a subject, comprising: administering an effective amount of a composition to a subject exposed to bacteria that cause necrotic enteritis with an associated gastrointestinal spasm, the composition produced from a process includingcombining a water soluble tannin with hydrogen peroxide at a tannin:peroxide weight ratio that ranges from about 1:1000 to about 10:1, the tannin having a molecular weight ranging from about 170 Daltons to about 4000 Daltons;removing free hydrogen peroxide from the combination; and,mixing the combination of the tannin and the hydrogen peroxide with a pharmaceutically acceptable excipient to create the formulation;wherein,the administering includes selecting a desired concentration of the formulation for the administering; and,the composition inhibits the onset of, and treats, a gastrointestinal spasm associated with necrotic enteritis in the subject when compared to a second subject in a control group also exposed to bacteria that cause necrotic enteritis in which the composition was not administered. 16. The method of claim 15, wherein the tannin is a hydrolysable tannin. 17. The method of claim 15, wherein the tannin is a water soluble condensed tannin. 18. The method of claim 15, wherein the tannin is a mixture of a hydrolysable tannin and a water soluble condensed tannin. 19. The method of claim 15, wherein the tannin is a flavanol. 20. The method of claim 15, wherein the tannin is a catechin. 21. The method of claim 15, wherein the tannin is gallic acid, epigallic acid, or a combination thereof. 22. The method of claim 15, wherein the tannin is a gallotannin. 23. The method of claim 15, wherein the tannin is an ellagitannin. 24. The method of claim 15, wherein the tannin is a punicalagin. 25. The method of claim 15, wherein the tannin is combined with the hydrogen peroxide as a component of a water extract of a plant tissue. 26. The method of claim 15, wherein the tannin is combined with the hydrogen peroxide as a component of an alcohol extract of a plant tissue. 27. A method of inhibiting the onset of, and treating, a gastrointestinal spasm associated with necrotic enteritis in a subject, the method comprising: administering an effective amount of a composition to a subject exposed to bacteria that cause necrotic enteritis with an associated gastrointestinal spasm, the composition having a water soluble polyphenol that was (i) water-extracted from pomegranate husk and green tea leaf and (ii) combined with hydrogen peroxide prior to the administering;wherein,the hydrogen peroxide concentration ranges from about 0.001% to about 2.0% based on total dry weight of the composition;the polyphenol comprises a tannin;the polyphenol has a molecular weight ranging from about 170 Daltons to about 4000 Daltons; and,the composition inhibits the onset of, and treats, a gastrointestinal spasm associated with necrotic enteritis in the subject when compared to a second subject in a control group also exposed to bacteria that cause necrotic enteritis in which the composition was not administered. 28. A method of inhibiting the onset of, and treating, a gastrointestinal spasm associated with necrotic enteritis in a subject, comprising: administering an effective amount of a composition to a subject exposed to bacteria that cause necrotic enteritis with an associated gastrointestinal spasm, the composition produced from a process includingextracting a water soluble polyphenol from a combination of green tea leaf and pomegranate husk;combining the polyphenol with hydrogen peroxide prior to the administering; wherein, the polyphenol has a molecular weight ranging from about 170 Daltons to about 4000 Daltons;selecting a desired concentration for the composition; and,diluting the composition to the desired concentration for the administering;wherein,the hydrogen peroxide concentration ranges from about 0.001% to about 2.0% based on total dry weight of the composition;the polyphenol comprises a tannin; and,the composition inhibits the onset of, and treats, a gastrointestinal spasm associated with necrotic enteritis in the subject when compared to a second subject in a control group also exposed to bacteria that cause necrotic enteritis in which the composition was not administered.