초록 ▼

A multi-layer sheet of collagen membrane material includes a barrier layer including an outer smooth barrier face and further including a fibrous face opposite the smooth barrier face, and a matrix layer of collagen material adhered to the fibrous face, the matrix layer including collagen I, collage

A multi-layer sheet of collagen membrane material includes a barrier layer including an outer smooth barrier face and further including a fibrous face opposite the smooth barrier face, and a matrix layer of collagen material adhered to the fibrous face, the matrix layer including collagen I, collagen III, or a combination thereof, the matrix layer carrying cultivated bone-forming cells including osteocytes, osteoblasts, stromal cells and/or stem cells committed to differentiation into bone-forming osteoblasts.

대표청구항 ▼

1. A multi-layer sheet of collagen membrane material comprising: a barrier layer which consists essentially of collagen I and collagen III, wherein the barrier layer has an outer smooth barrier face and a fibrous face opposite said smooth barrier face; anda matrix layer which contains collagen I, co

1. A multi-layer sheet of collagen membrane material comprising: a barrier layer which consists essentially of collagen I and collagen III, wherein the barrier layer has an outer smooth barrier face and a fibrous face opposite said smooth barrier face; anda matrix layer which contains collagen I, collagen III or a combination of collagen I/collagen III, and excludes substantial amounts of collagen II, said matrix layer carrying expanded bone-forming cells in bone marrow material,wherein said matrix layer is adhered to said fibrous face of said barrier layer. 2. The multi-layer sheet of claim 1 wherein said membrane material has a thickness of about 0.1-5 mm. 3. The multi-layer sheet of claim 1 wherein said matrix layer further carries at least one bone growth-stimulating agent or cartilage growth-stimulating agent. 4. A method for reconstructing bone tissue, comprising applying the collagen membrane material of claim 1 to a bone defect, wherein the matrix layer is placed in contact with the bone defect, so as to promote reconstruction of bone tissue at said defect. 5. The method of claim 4 wherein said membrane material has a thickness of about 0.1-5 mm. 6. The method of claim 4 wherein said matrix layer further carriers at least one bone growth-stimulating agent or cartilage growth-stimulating agent.