초록 ▼

This invention provides cellulose ester interpolymers, and methods of oxidizing cellulose interpolymers and cellulose ester interpolymers. The invention also provides routes to access carboxylated cellulose ester derivatives with high acid numbers wherein the carboxyl group is attached directly to t

This invention provides cellulose ester interpolymers, and methods of oxidizing cellulose interpolymers and cellulose ester interpolymers. The invention also provides routes to access carboxylated cellulose ester derivatives with high acid numbers wherein the carboxyl group is attached directly to the cellulose backbone by a carbon-carbon bond. Through functionalization of an intermediate aldehyde, the corresponding cationic or zwitterionic cellulose ester derivatives can also be accessed. The interpolymers of the present invention have a number of end-use applications, for example, as binder resins in various types of coating compositions and as drug delivery agents.

대표청구항 ▼

1. A method for converting a primary alcohol to a formyl carboxylate, or mixture thereof, comprising: adding a 4-substituted piperidine nitroxyl derivative, a primary oxidant, and a terminal oxidant to a homogeneous solution to form a reaction mixture, wherein the homogeneous solution has a pH of le

1. A method for converting a primary alcohol to a formyl carboxylate, or mixture thereof, comprising: adding a 4-substituted piperidine nitroxyl derivative, a primary oxidant, and a terminal oxidant to a homogeneous solution to form a reaction mixture, wherein the homogeneous solution has a pH of less than about 4 and comprises a cellulose interpolymer comprising a primary alcohol functional group;passing of a reaction period sufficient to affect conversion of the primary alcohol functional group to a formyl group or a carboxy group and thus produce an oxidized cellulose interpolymer, wherein the oxidized, cellulose interpolymer consists of anhydroglucose units; as the non-terminal monomer units of the oxidized cellulose interpolymer, wherein R1, R2, R3, R4, and R5 are independently selected from the group consisting of hydrogen and C2-C12 acyl groups, and X is formyl or carboxy. 2. The method of claim 1, wherein the primary oxidant is a Mn(III) sat. 3. The method of claim 2, wherein the Mn(III) salt is manganese triacetate. 4. The method of claim 1, when the primary oxidant further comprises a salt of Cu, Mg, Fe, Na, K, or mixtures thereof. 5. The method of claim 1, wherein the reaction mixture further comprises water. 6. The method of claim 1, wherein the reaction mixture further comprises water and a C2-C12 alkyl acid. 7. The method of claim 1, wherein the 4-substituted piperidine nitroxyl derivative is a 4-amino substituted 2,2,6,6-tetramethyl piperidin-1-oxyl derivative. 8. The method of claim 1, wherein the 4-substituted piperidine nitroxyl derivative is 4-amino 2,2,6,6-tetramethyl piperidin-1-oxyl. 9. The method of claim 1, wherein the 4-substituted piperidine nitroxyl derivative is a 4-(C1-C4 acetamido)-2,2,6,6-tetramethylpiperidin-1-oxyl. 10. The method of claim 1, wherein the 4-substituted piperidine nitroxyl derivative is 4-acetamido-2,2,6,6-tramethylpiperidin-1-oxyl. 11. The method of claim 1, wherein the 4-substituted piperidine nitroxyl derivative is immobilized on an inert resin. 12. The method of claim 1, wherein the oxidized cellulose interpolymer has an acid number greater than 30.