The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing
The present invention generally relates to systems and methods for monitoring and/or providing feedback for drugs or other pharmaceuticals taken by a subject. In one aspect, the present invention is directed to devices and methods for determining a species within the skin of a subject; and producing feedback to a subject based on the determination of the species. The feedback may be, for example, visual, audible, tactile, a change in temperature, etc. In some cases, information regarding the determination of the species may be transmitted to another entity, e.g., a health care provider, a computer, a relative, etc., which may then provide feedback to the subject in some fashion. In some cases, the feedback may be directly indicative of the species, e.g., whether the species is present, the concentration of the species, whether a by-product of a reaction involving the species is present, whether a compound affected by the species is present, etc. However, the feedback may also be indirect in some embodiments. For example, the subject may be presented with an external reward, e.g., based on the determination of the species within the skin. For instance, a reward such as cash, coupons, songs, discounts, personal items, etc., may be offered based on the level of compliance of the subject. Still other aspects of the invention are generally directed to kits involving such devices (with or without the drug to be monitored), methods of promoting such systems, or the like.
대표청구항▼
1. A device, comprising: a sensor configured, adapted or designed to determine a species withdrawn from a subject;a processor configured to determine compliance of the subject to a prescription based on the determination of the species; anda device indicator configured to indicate availability of an
1. A device, comprising: a sensor configured, adapted or designed to determine a species withdrawn from a subject;a processor configured to determine compliance of the subject to a prescription based on the determination of the species; anda device indicator configured to indicate availability of an external reward based on the compliance of the subject to the prescription, wherein the external reward is available from a machine physically separate from the device. 2. The device of claim 1, wherein the device indicator comprises a display screen. 3. The device of claim 1, wherein the device indicator is configured to produce a coupon. 4. The device of claim 1, wherein the device indicator comprises a light. 5. The device of claim 1, wherein the external reward comprises a coupon. 6. The device of claim 1, wherein the external reward comprises a monetary reward. 7. The device of claim 1, wherein the external reward comprises a visual display. 8. The device of claim 1, wherein the external reward comprises music. 9. The device of claim 1, wherein the external reward comprises a movie. 10. The device of claim 1, wherein the external reward comprises an advertisement. 11. The device of claim 1, wherein the external reward comprises a link to a web page. 12. A method, comprising: withdrawing a species from a subject using a device fastened to the subject;determining information comprising an amount and/or a concentration of the species using at least the device;transmitting the information to a physically separate computing device;determining compliance of the subject to a prescription, using the physically separate computing device, based on the transmitted information; andusing the computing device to provide, via an output device, non-number feedback to the subject based on the compliance of the subject to the prescription. 13. The method of claim 12, wherein the output device provides visual feedback. 14. The method of claim 12, wherein the output device provides auditory feedback. 15. The method of claim 14, wherein the output device provides music. 16. The method of claim 12, wherein the species is contained in blood withdrawn from the subject. 17. The method of claim 12, wherein the device is configured to withdraw the species from the subject using a microneedle. 18. The method of claim 12, wherein the device is configured to apply a vacuum to the skin. 19. The method of claim 12, further comprising an activator for activating the device to withdraw the species from the subject. 20. A method, comprising: determining information representing a property of a species withdrawn from the blood of a subject using a device immobilized to the skin of the subject;transmitting the information, using the device, to a machine physically separate from the device;determining compliance of the subject, using the machine, to a prescription based on the transmitted information; andtransmitting a signal from the machine to the device to cause the device to indicate availability of an external reward available from the machine, wherein the signal is based on compliance of the subject to the prescription. 21. The method of claim 20, wherein the device is adhered to the skin of the subject. 22. A method, comprising: providing a subject to which a drug has been administered, wherein the subject has a condition suspected of being treatable by the drug, and wherein the drug administered to the subject can not be distinguished after administration, by the subject, from a placebo without any external equipment;determining a species withdrawn from the blood of the subject that is indicative of the drug administered to the subject;determining compliance of the subject to a prescription involving the drug, based on the withdrawn species; andproviding feedback to the subject and/or another person based on the compliance of the subject to the prescription. 23. The method of claim 22, wherein the species is the drug. 24. The method of claim 22, wherein the species withdrawn from a subject is indicative of the effect of the drug administered to the subject. 25. The method of claim 22, wherein the species withdrawn from a subject is indicative of the amount of the drug administered to the subject. 26. A method, comprising: providing a subject to which a drug has been administered, wherein the subject has a condition suspected of being treatable by the drug, and wherein the drug does not cause a measurable change to the condition of the subject within the first 24 hours after administering the drug;determining a species withdrawn from the blood of the subject that is indicative of the drug administered to the subject;determining compliance of the subject to a prescription involving the drug, based on the withdrawn species; andproviding feedback to the subject and/or another person based on the compliance of the subject to the prescription. 27. The method of claim 26, wherein the drug does not cause a measurable change to the condition of the subject within the first week after administering the drug. 28. The method of claim 26, wherein the drug does not cause a measurable change to the condition of the subject within the first four weeks after administering the drug.
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Yamada Yoshihisa (Kyoto JPX) Matsuoka Yuzo (Toyonaka JPX), 6-Halo-1,2,3,4-tetrahydroquinazoline-4-spiro-4-imidazolidine-2,2′5′-triones useful for the treatment and prophylaxis o.
Lattin Gary A. (Forest Lake MN) Padmanabhan Rama (Arden Hills MN) Grace Michael J. (Coon Rapids MN) Sorenson Paul D. (Blaine MN) Phipps Joseph B. (Plymouth MN) McNichols Larry A. (Coon Rapids MN), Activity controlled electrotransport drug delivery device.
Bcker Dirk (Heidelberg DEX) Haar Hans-Peter (Wiesloch DEX) Blasberg Peter (Weinheim DEX) Kotulla Reinhard (Lambsheim DEX), Analytical system for monitoring a substance to be analyzed in patient-blood.
Grace, John P.; Loomis, Neil W.; Schapira, Thomas G.; Wong, Sie Ting; Noonan, Kristin M.; Lowery, Michael G.; Bojan, Pete M.; Schmidt, Daniel P.; Huang, Tung-Ming; Jon G. Hiltibran; Pope, Mark R.; Ko, Apparatus and method for the collection of interstitial fluids.
Shefer Adi ; Shefer Shmuel David ; Teffenhart John M., Application of film forming technology to fragrance control release systems; and resultant fragrance control release systems.
Woudenberg Timothy W. ; Albin Michael ; Kowallis Reid B. ; Raysberg Yefim ; Ragusa Robert P. ; Winn-Deen Emily S., Device for multiple analyte detection.
Down, James; Harvey, Noel G.; Martin, Frank E.; Pettis, Ronald J.; Lastovich, Alexander G., Device for withdrawing or administering a substance and method of manufacturing a device.
Prausnitz, Mark R.; Allen, Mark G.; Henry, Sebastien; McAllister, Devin V.; Ackley, Donald E.; Jackson, Thomas, Devices and methods for enhanced microneedle penetration of biological barriers.
Latterell Scott T. ; Brinda Paul D. ; Hilgers Michael E. ; Shoup Michael J. ; Hoegh Thomas B. ; Erickson Brian J., Enhanced interstitial fluid collection.
Latterell Scott T. ; Brinda Paul D. ; Hilgers Michael E. ; Shoup Michael J. ; Hoegh Thomas B. ; Erickson Brian J., Enhanced interstitial fluid collection.
Latterell, Scott T.; Brinda, Paul D.; Hilgers, Michael E.; Shoup, Michael J.; Hoegh, Thomas B.; Erickson, Brian J., Enhanced interstitial fluid collection.
Eppstein Jonathan A. (Atlanta GA) Eppstein Deborah A. (Salt Lake City UT) Kost Joseph (Omer MA ILX) Langer Robert S. (Newton MA), Enhancement of transdermal monitoring applications with ultrasound and chemical enhancers.
Lum Paul ; Leonard Leslie A. ; Verdonk Edward D. ; Freeman Dominique M. ; Greenstein Michael ; Keely-Templin Catherine, Extraction and transportation of blood for analysis.
Paul Lum ; Leslie A. Leonard ; Edward D. Verdonk ; Dominique M. Freeman ; Michael Greenstein ; Catherine Keely-Templin, Extraction and transportation of blood for analysis.
Keeling Michael R. (19 Rockmill End Willingham ; Cambridgeshire GB2) Langrick David J. (45 Water Lane Oakington ; Cambridgeshire GB2), Fluid application method and apparatus.
Garcia Fernando S. (Eden Prairie MN) Ginnow-Merkert Hartmut (Eden Prairie MN) Anderson Paul J. (Eden Prairie MN) Hudson Bertram J. (Eden Prairie MN), Glucose medical monitoring system.
D\Angelo Joseph P. (Miami FL) Schur Henry (Miami FL) Han Kedu (Miami FL) Glenn Daniel J. (Hollywood FL), Integrated system for biological fluid constituent analysis.
Erickson Brian J. (Woodbury MN) Hilgers Michael E. (Roseville MN) Hendrickson Tracy A. (Minnetonka MN) Shapland J. Edward (Shoreview MN) Solomon Frank A. (Plymouth MN) Knudson Mark B. (Shoreview MN), Interstitial fluid collection and constituent measurement.
Erickson Brian J. ; Hilgers Michael E. ; Hendrickson Tracy A. ; Shapland J. Edward ; Solomon Frank A. ; Knudson Mark B., Interstitial fluid collection and constituent measurement.
Erickson Brian J. ; Hilgers Michael E. ; Hendrickson Tracy A. ; Shapland J. Edward ; Solomon Frank A. ; Knudson Mark B., Interstitial fluid collection and constituent measurement.
Erickson Brian J. ; Hilgers Michael E. ; Hendrickson Tracy A. ; Shapland J. Edward ; Solomon Frank A. ; Knudson Mark B., Interstitial fluid collection and constituent measurement.
Erickson, Brian J.; Hilgers, Michael E.; Hendrickson, Tracy A.; Shapland, J. Edward; Solomon, Frank A.; Knudson, Mark B., Interstitial fluid collection and constituent measurement.
Anderson Paul J. (Bloomington MN) Jessen Ross A. (Chaska MN) Linde David R. (Maple Grove MN) Jones Richard E. (Bloomington MN) Walter Bert (Mendota Heights MN) Christenson Paul E. (Apple Valley MN), Medical diagnostic system.
Cunningham David D. ; Henning Timothy P. ; Shain Eric B. ; Young Douglas F. ; Lowery Michael G. ; Graham Hugh W., Method and apparatus for obtaining blood for diagnostic tests.
Cunningham David D. ; Henning Timothy P. ; Shain Eric B. ; Young Douglas F. ; Lowery Michael G. ; Schapira Thomas G., Method and apparatus for obtaining blood for diagnostic tests.
Cunningham David D. ; Henning Timothy P. ; Shain Eric B. ; Young Douglas F. ; Lowery Michael G. ; Schapira Thomas G., Method and apparatus for obtaining blood for diagnostic tests.
Cunningham David D. ; Henning Timothy P. ; Shain Eric B. ; Young Douglas F. ; Muetterties Andrew J. ; Schapira Thomas G. ; Chambers Geoffrey R.,GBX ; Hughes Graham J.,GBX ; Watkin Jared L.,GBX ; Prok, Method and apparatus for obtaining blood for diagnostic tests.
Cunningham David D. ; Henning Timothy P. ; Shain Eric B. ; Young Douglas F. ; Muetterties Andrew J. ; Schapira Thomas G. ; Chambers Geoffrey R.,GBX ; Hughes Graham J.,GBX ; Watkin Jared L.,GBX ; Prok, Method and apparatus for obtaining blood for diagnostic tests.
Cunningham, David D.; Henning, Timothy P.; Shain, Eric B.; Young, Douglas F.; Muetterties, Andrew J.; Schapira, Thomas G.; Chambers, Geoffrey R.; Hughes, Graham J.; Watkin, Jared L.; Prokop, Gary F.;, Method and apparatus for obtaining blood for diagnostic tests.
Shain Eric B. ; Lowery Michael G. ; Cunningham David D. ; Henning Timothy P. ; Young Douglas F., Method and apparatus for obtaining blood for diagnostic tests.
Henning Timothy P. ; Hiltibran Robert G. ; Cunningham David D. ; Shain Eric B. ; Tarkowski Brian J. ; Young Douglas F., Method and apparatus for obtaining interstitial fluid for diagnostic tests.
Mitragotri, Samir S.; Kost, Joseph; Kellogg, Scott C.; Warner, Nicholas F., Method and apparatus for producing homogenous cavitation to enhance transdermal transport.
Lowe,Christopher Robin; Davidson,Colin Alexander Bennett; Blyth,Jeffrey; Kabilan,Satyamoorthy; Marshall,Alexander James; Gonzalez,Blanca Madrigal; James,Anthony Peter, Method of detecting an analyte in a fluid.
Santos Camila A. ; Jacob Jules S. ; Hertzog Benjamin A. ; Carino Gerardo P. ; Mathiowitz Edith, Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients.
Lastovich, Alexander G.; Alarcon, Jason B.; Dekker, III, John P.; Haider, M. Ishaq; Mikszta, John A.; Martin, Frank E.; O'Connor, Scott A., Microprotrusion arrays and methods for using same to deliver substances into tissue.
Lastovich,Alexander G.; Alarcon,Jason B.; Dekker, III,John P.; Haider,M. Ishaq; Mikszta,John A.; Martin,Frank E.; O'Connor,Scott A., Microprotrusion arrays and methods for using same to deliver substances into tissue.
Domb Abraham J.,ILX ; Gref Ruxandra,FRX ; Minamitake Yoshiharu,JPX ; Peracchia Maria Teresa,ITX ; Langer Robert S., Nanoparticles and microparticles of non-linear hydrophilic-hydrophobic multiblock copolymers.
Chad A. Mirkin ; Robert L. Letsinger ; Robert C. Mucic ; James J. Storhoff ; Robert Elghanian, Nanoparticles having oligonucleotides attached thereto and uses therefor.
Chen James L. (East Brunswick NJ) Cilento Rudolfo D. (North Brunswick NJ) Hill John A. (New Brunswick NJ) La Via Anthony L. (East Brunswick NJ), Ostomy adhesive.
Patel Dinesh C. (Murray UT) Chang Yunik (Lakewood NJ), Penetration enhancement with binary system of oleic acid, oleins, and oleyl alcohol with lower alcohols.
Gorsuch, Reynolds G.; Grage, Henry; Handley, Jr., Harold H.; Peters, Harold W.; Kearns, Jacob C., Specialized hollow fiber membranes for plasmapheresis and ultrafiltration.
Smith,Alan; Delcher,Harry K.; Eppstein,Jonathan A.; Farquhar,David; Hatch,Michael R.; Kumar,Krishna, System and method for fluid management in a continuous fluid collection and sensor device.
Coston,Anthony F.; Sun,Ying; Oakeson,Ralph W.; Wisniewski,Stephen J.; Wang,Jonas C. T., Tissue electroperforation for enhanced drug delivery and diagnostic sampling.
Sanders Harold F. (Palo Alto CA) Cheng Yu-Ling (Cupertino CA) Enscore David J. (Saratoga CA) Libicki Shari B. (Palo Alto CA), Transdermal drug composition with dual permeation enhancers.
Bernstein, Howard; Chickering, III, Donald E.; Levinson, Douglas A.; Walt, David R.; Davis, Shawn; Haghgooie, Ramin; Langer, Robert S.; Blicharz, Timothy M., Devices and techniques associated with diagnostics, therapies, and other applications, including skin-associated applications.
Haghgooie, Ramin; Chickering, III, Donald E.; Davis, Shawn; Michelman, Mark; Bernstein, Howard; Horton, Kristin, Plasma or serum production and removal of fluids under reduced pressure.
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