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Kafe 바로가기국가/구분 | United States(US) Patent 등록 |
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국제특허분류(IPC7판) |
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출원번호 | US-0078232 (2005-03-10) |
등록번호 | US-9044199 (2015-06-02) |
발명자 / 주소 |
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출원인 / 주소 |
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대리인 / 주소 |
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인용정보 | 피인용 횟수 : 3 인용 특허 : 547 |
The present invention relates generally to systems and methods for measuring an analyte in a host. More particularly, the present invention relates to systems and methods for transcutaneous measurement of glucose in a host.
1. A device for measurement of an analyte concentration in a host, the device comprising: a sensor comprising a first electrode and a second electrode coaxially located with the first electrode, wherein the sensor comprises an in vivo portion configured for insertion into a host and an ex vivo porti
1. A device for measurement of an analyte concentration in a host, the device comprising: a sensor comprising a first electrode and a second electrode coaxially located with the first electrode, wherein the sensor comprises an in vivo portion configured for insertion into a host and an ex vivo portion configured for electrical connection to sensor electronics located outside of the host, wherein the ex vivo portion comprises a first electrical connection area associated with the first electrode and a second electrical connection area associated with the second electrode;a membrane system disposed on an electroactive portion of the first electrode; anda contact subassembly configured to electrically connect the sensor with sensor electronics, wherein a first electrically conductive portion of the contact subassembly circumscribes at least a portion of a periphery of the first electrical connection area, and wherein a second electrically conductive portion of the contact subassembly circumscribes at least a portion of a periphery of the second electrical connection area. 2. The device of claim 1, wherein the electroactive portion of the first electrode has a surface area of from about 0.000084 cm2 to about 0.016 cm2. 3. The device of claim 1, wherein the first and second electrodes each comprise working electrodes. 4. The device of claim 1, wherein the second electrode is juxtapositioned to the first electrode. 5. The device of claim 1, wherein the first electrode is configured to generate a first signal associated with analyte and non-analyte related measurements, and wherein the second electrode is configured to generate a second signal associated with non-analyte related measurements, wherein non-analyte related measurements comprise a baseline measurement or an interfering species measurement. 6. The device of claim 5, wherein the sensor electronics are configured to subtract the second signal from the first signal. 7. The device of claim 5, wherein the membrane system comprises an interference domain configured to restrict flow of one or more interfering species. 8. The device of claim 1, wherein the first electrode is formed from a wire of less than about 0.01 inches in diameter. 9. The device of claim 1, wherein the electroactive portion of the second electrode is distributed along a length of the first electrode. 10. The device of claim 1, wherein a sizing of the first electrode, a resistivity of the membrane system to glucose, and a configuration of the sensor electronics are configured and arranged such that the system generates less than about 100 picoAmps of current per 1 mg/dL of glucose concentration. 11. The device of claim 1, wherein the first electrode comprises a core of a first metal and an outer layer of a second metal, wherein the outer layer is electroplated on the core. 12. The device of claim 1, wherein the first electrode is formed from a plated wire. 13. The device of claim 1, wherein the first electrode comprises a core of a first metal and an outer layer of a second metal, wherein the first metal comprises stainless steel and the second metal comprises platinum. 14. The device of claim 1, wherein at least a portion of the sensor is configured for insertion through a dermis of a host, and wherein the sensor comprises a level of flexibility sufficient to provide for flexing of the sensor with movements of host tissue during use. 15. The device of claim 14, wherein the sensor is configured for insertion within a needle through the dermis. 16. The device of claim 1, wherein the first electrode comprises a core of a first metal and an outer layer of a second metal, wherein the outer layer is thin relative to the core. 17. The device of claim 1, wherein the first electrode comprises a core of a first metal and an outer layer of a second metal, wherein the outer layer comprises a monolithic coating circumscribing a length of the core. 18. The device of claim 1, wherein at least a portion of the contact subassembly is configured to comply upon application of pressure. 19. The device of claim 1, wherein the contact subassembly comprises one or more of a domed metallic contact, a metallic spring, a conductive elastomer, a cantilevered finger, a pogo pin, or a stiff plastic. 20. The device of claim 1, wherein at least a portion of the contact subassembly is configured to provide a wiping action between the contact subassembly and mating contacts of the sensor electronics during electrical connection between the contact subassembly and the sensor electronics. 21. The device of claim 1, wherein at least a portion of the contact subassembly is configured to apply a force against mating contacts of the sensor electronics during electrical connection between the contact subassembly and the sensor electronics. 22. The device of claim 1, wherein at least a portion of the membrane system comprises an enzyme, and wherein the device further comprises a material comprising a fluorochemical or a silicone, wherein the material is configured to enhance oxygen transport to the enzyme. 23. The device of claim 22, wherein the material is configured to extend from the ex vivo portion to the in vivo portion. 24. The device of claim 22, wherein the membrane system comprises the material. 25. The device of claim 22 or 24, wherein the material comprises a fluorocarbon. 26. The device of claim 1, wherein the first electrode comprises the working electrode, and wherein the second electrode comprises a reference electrode or counter electrode. 27. The device of claim 1, wherein the first electrode comprises a core of a first metal and an outer layer of a second metal, wherein the first electrode comprises a core formed of a first metal and an outer layer formed of a second metal. 28. The device of claim 1, wherein the first electrical connection area is longitudinally spaced relative to the second electrical connection area along a longitudinal axis of the sensor. 29. The device of claim 1, further comprising an insulator disposed between the first electrode and the second electrode. 30. A sensor for measurement of a glucose concentration in a host, the sensor comprising: a first wire comprising a metallic rod coated with an insulating material;first and second electrodes located on an outer surface of the insulating material; anda membrane system disposed on an electroactive portion of the first electrode, wherein the membrane system comprises a permeability ratio of oxygen-to-glucose of at least about 50:1, wherein the electroactive portion of the first electrode has a surface area of from about 0.000084 cm2 to about 0.016 cm2, and wherein the sensor is configured to generate less than about 100 picoAmps of current per 1 mg/dL of glucose concentration. 31. The sensor of claim 30, wherein the membrane system comprises a permeability ratio of oxygen-to-glucose of at least about 200:1. 32. The sensor of claim 30, wherein the insulated rod has a diameter of less than about 0.001 inches. 33. The sensor of claim 30, wherein the first electrode is deposited on the first wire.
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