Electrode structures and methods for their use in cardiovascular reflex control
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
A61N-001/00
A61N-001/36
A61B-005/02
A61N-001/05
A61N-001/08
A61N-001/37
출원번호
US-0300232
(2011-11-18)
등록번호
US-9044609
(2015-06-02)
발명자
/ 주소
Bolea, Stephen L.
Kieval, Robert S.
Persson, Bruce J.
Serdar, David J.
Keith, Peter T.
Irwin, Eric D.
Rossing, Martin A.
출원인 / 주소
CVRx, Inc.
대리인 / 주소
Patterson Thuente Pedersen, P.A.
인용정보
피인용 횟수 :
5인용 특허 :
281
초록▼
Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located i
Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
대표청구항▼
1. A method, comprising: implanting a baroreceptor activation device within a patient, the baroreceptor activation device including an electrode, wherein the baroreceptor activation device is implanted such that the electrode is in contact with an outer surface of a blood vessel and proximate a baro
1. A method, comprising: implanting a baroreceptor activation device within a patient, the baroreceptor activation device including an electrode, wherein the baroreceptor activation device is implanted such that the electrode is in contact with an outer surface of a blood vessel and proximate a baroreceptor in a wall of the blood vessel; andactivating, deactivating, or otherwise modulating the baroreceptor activation device as part of a baroreflex therapy. 2. The method of claim 1, wherein activating, deactivating, or otherwise modulating the baroreceptor activation device comprises delivering electric current through the electrode directly to the blood vessel to stimulate the baroreceptor. 3. The method of claim 1, wherein activating, deactivating, or otherwise modulating the baroreceptor activation device comprises delivering electric current through the electrode directly to the wall of the blood vessel to locally stimulate the baroreceptor and minimize stimulation outside the wall of the blood vessel. 4. The method of claim 1, further comprising: implanting a sensor within the patient, the sensor configured for generating a sensor signal indicative of a need for baroreflex therapy;activating, deactivating, or otherwise modulating the baroreceptor activation device based at least in part on the sensor signal as part of the chronic baroreflex therapy. 5. The method of claim 1, wherein the blood vessel is a carotid artery. 6. The method of claim 1, wherein the blood vessel is a carotid sinus. 7. The method of claim 1, wherein the blood vessel is a subclavian artery. 8. The method of claim 1, wherein the blood vessel is an aortic arch. 9. The method of claim 1, wherein the blood vessel is a brachiocephalic artery. 10. The method of claim 1, further comprising: implanting a pulse generator housing within the patient, the pulse generator housing including an indifferent electrode and further including a control system within the pulse generator housing, the control system programmed to deliver the baroreflex therapy. 11. A method, comprising: causing a baroreceptor activation device to be manufactured and made available to a user, the baroreceptor activation device having an electrode;causing the baroreceptor activation device to be implanted such that the electrode is in contact with an outer surface of a blood vessel so as to be proximate a baroreceptor in a wall of the blood vessel;causing the baroreceptor activation device to be activated, deactivated, or otherwise modulated as part of a baroreflex therapy. 12. The method of claim 11, further comprising: causing a sensor to be manufactured and made available to the user, the sensor configured for generating a sensor signal indicative of a need for baroreflex therapy;causing the sensor to be implanted within the patient, the sensor configured for generating a sensor signal indicative of a need for baroreflex therapy;causing the baroreceptor activation device to be activated, deactivated, or otherwise modulated based at least in part on the sensor signal as part of the chronic baroreflex therapy. 13. The method of claim 11, further comprising: providing a pulse generator housing including an indifferent electrode and a control system within the pulse generator housing, the control system coupled to the baroreceptor activation device and programmed to deliver the baroreflex therapy. 14. The method of claim 11, wherein causing the baroreceptor activation device to be activated, deactivated, or otherwise modulated as part of a baroreflex therapy comprises delivering electric current through the electrode directly to the blood vessel to stimulate the baroreceptor. 15. A method, comprising: providing a baroreceptor activation device to a user, the baroreceptor activation device having an electrode; andproviding instructions to the user, comprising: implanting the baroreceptor activation device within a patient such that the electrode is in contact with an outer surface of a blood vessel so as to be proximate a baroreceptor in a wall of the blood vessel; andactivating, deactivating, or otherwise modulating the baroreceptor activation device as part of a baroreflex therapy. 16. The method of claim 15, wherein activating, deactivating, or otherwise modulating the baroreceptor activation device comprises delivering electric current through the electrode directly to the baroreceptor in the wall of the blood vessel. 17. The method of claim 15, wherein activating, deactivating, or otherwise modulating the baroreceptor activation device comprises delivering electric current through the electrode directly to wall of the blood vessel to locally stimulate the baroreceptor and minimize stimulation outside the wall of the blood vessel. 18. The method of claim 15, wherein providing a baroreceptor activation device having an electrode comprises providing a baroreceptor activation device having a monopolar patch electrode. 19. The method of claim 15, further comprising: implanting a sensor within the patient, the sensor configured for generating a sensor signal indicative of a need for baroreflex therapy;activating, deactivating, or otherwise modulating the baroreceptor activation device based at least in part on the sensor signal as part of the chronic baroreflex therapy. 20. The method of claim 15, further comprising: providing a pulse generator housing including an indifferent electrode and a control system within the pulse generator housing, the control system coupled to the baroreceptor activation device and programmed to deliver the baroreflex therapy,wherein the instructions further comprise implanting the pulse generator within the patient.
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