System and method including multiple processing lanes executing processing protocols
원문보기
IPC분류정보
국가/구분
United States(US) Patent
등록
국제특허분류(IPC7판)
G01N-035/00
G01N-001/31
G01N-035/10
B01L-003/00
B01L-007/00
G01N-035/04
C12Q-003/00
G05B-013/02
G01F-023/24
G01F-023/26
G06F-019/10
C12M-001/34
C12Q-001/68
G01N-001/38
B01L-003/02
출원번호
US-0747633
(2013-01-23)
등록번호
US-9046455
(2015-06-02)
발명자
/ 주소
Wilson, Brian D.
Anderson, David L.
Davis, Matthew S.
Erickson, Matthew D.
Johnson, Alan N.
Maurer, Garrick A.
Rosen, Michael J.
Sauerburger, Mark F.
Schmidt, Daniel R.
Wiltsie, Joshua D.
출원인 / 주소
Beckman Coulter, Inc.
대리인 / 주소
Kilpatrick Townsend & Stockton LLP
인용정보
피인용 횟수 :
1인용 특허 :
225
초록▼
Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locat
Systems and methods for processing and analyzing samples are disclosed. The system may process samples, such as biological fluids, using assay cartridges which can be processed at different processing locations. In some cases, the system can be used for PCR processing. The different processing locations may include a preparation location where samples can be prepared and an analysis location where samples can be analyzed. To assist with the preparation of samples, the system may also include a number of processing stations which may include processing lanes. During the analysis of samples, in some cases, thermal cycler modules and an appropriate optical detection system can be used to detect the presence or absence of certain nucleic acid sequences in the samples. The system can be used to accurately and rapidly process samples.
대표청구항▼
1. A system for determining the presence of a nucleic acid in a sample, the system comprising: a first assay cartridge comprising a first plurality of reagent wells and a first reaction well;a second assay cartridge comprising a second plurality of reagent wells and a second reaction well;a first pr
1. A system for determining the presence of a nucleic acid in a sample, the system comprising: a first assay cartridge comprising a first plurality of reagent wells and a first reaction well;a second assay cartridge comprising a second plurality of reagent wells and a second reaction well;a first processing lane;a second processing lane;a third processing lane;a transfer shuttle operatively coupled to the first, second, and third processing lanes; anda controller operatively coupled to each of the first, second and third processing lanes and the transfer shuttle, the controller programmed to execute a first protocol and a second protocol, wherein the first protocol directs the transfer shuttle to move the first assay cartridge from the first processing lane to the second processing lane and the second protocol directs the transfer shuttle to move the second assay cartridge from the first processing lane to the third processing lane without moving the second assay cartridge to the second processing lane, and wherein the system further comprisesa preparation location, wherein the first, second, and third processing lanes are in the preparation location;a reaction vessel for containing a processed sample;an analysis location for characterizing the processed sample contained in the reaction vessel;a transport device configured to transfer the reaction vessel between the preparation location and the analysis location; anda plurality of identical analytical units in the analysis location. 2. The system of claim 1, where the first, second, and third processing lanes are parallel to each other and are also perpendicular to an orientation of the transfer shuttle. 3. The system of claim 1, wherein the first processing lane comprises a cartridge loading lane, and the second processing lane is a heating lane, and the third processing lane is a wash lane. 4. The system of claim 1, wherein the first, second, and third processing lanes are selected from the group consisting of a heating lane configured to warm an assay cartridge, an amplification preparation lane, a temperature stabilization heating lane configured to maintain the temperature of an assay cartridge, an elution lane, and a wash lane. 5. The system of claim 1, wherein the first assay cartridge is a DNA analysis cartridge and the second assay cartridge is an RNA analysis cartridge. 6. The system of claim 1, wherein the reaction vessel is a sealed vessel. 7. The system of claim 1, wherein the transport device comprises a pipettor mandrel. 8. A method comprising: executing a first protocol by a controller in a system, wherein in the first protocol, the controller directs a transfer shuttle to move a first assay cartridge from a first processing lane to a second processing lane in the system; andexecuting a second protocol by the controller, wherein in the second protocol, the controller directs the transfer shuttle to move a second assay cartridge from the first processing lane to a third processing lane in the system without moving the second assay cartridge to the second processing lane,wherein the first assay cartridge comprises a first plurality of reagent wells and a first reaction well, andwherein the second assay cartridge comprises a second plurality of reagent wells and a second reaction well, and wherein the system comprisesa preparation location, wherein the first, second, and third processing lanes are in the preparation location;a reaction vessel for containing a processed sample;an analysis location for characterizing the processed sample contained in the reaction vessel;a transport device configured to transfer the reaction vessel between the preparation location and the analysis location; anda plurality of identical analytical units in the analysis location. 9. The method of claim 8, where the first, second, and third processing lanes are parallel to each other and are also perpendicular to an orientation of the transfer shuttle. 10. The method of claim 8, wherein the first processing lane comprises a cartridge loading lane, and the second processing lane is a heating lane, and the third processing lane is a wash lane. 11. The method of claim 8, wherein the first, second, and third processing lanes are selected from the group consisting of a heating lane configured to warm an assay cartridge, an amplification preparation lane, a temperature stabilization heating lane configured to maintain the temperature of an assay cartridge, an elution lane, and a wash lane. 12. The method of claim 8, wherein the first assay cartridge is for DNA analysis and the second assay cartridge is for RNA analysis.
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